Clinical trials
Spine Surgery clinical trials
Below are recruiting spine surgery clinical trials, each written for real people, not researchers. We’re tracking 90 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05029726RecruitingPhase 4
Numbing medicine during back surgery to reduce pain
This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.
Chicago, IllinoisAges 18–80 - NCT05856539Recruiting
Numbing nerve block during minimally invasive low back surgery
This trial tests whether an “ESP block” (a numbing injection near the spine) can help control pain during minimally invasive low back fusion surgery. If you’re having this surgery, the goal is to improve comfort and reduce pain medicine needs.
New York, New YorkAges 18–80 - NCT04628663Recruiting
Dexmedetomidine and eye pressure during spine surgeries
This study looks at whether a specific anesthesia-related medicine (dexmedetomidine) affects eye pressure during planned spine operations done with the patient lying face-down under general anesthesia. It may help doctors choose safer anesthesia to reduce risks related to eye pressure changes.
Athens, AtticaAges 18–90 - NCT03849443RecruitingEarly Phase 1
Testing tranexamic acid to reduce bleeding after spine fusion
This trial studies whether a single dose or multiple doses of tranexamic acid (TXA) can reduce the chance you need a blood transfusion after spine fusion surgery. It also compares two different ways TXA may be given (by mouth and through a vein) to see which approach works best and is safe.
Chicago, IllinoisAges 18 years+ - NCT07646184Enrolling by invitation
Nerve Block Techniques for Upper Back Surgery Pain
This trial compares two types of numbing injections (nerve blocks) used during upper back spine surgery to see which one works better for pain relief. Both techniques are already used in surgery; this study tests which may be more effective.
Tanta, State/Province:*Ages 18–60 - NCT07307495Recruiting
Pain relief after back surgery and its effect on recovery
This study tests a new painkiller, oliceridine fumarate, given through a pump after lumbar spine surgery. The goal is to see if it helps the bowels and stomach recover faster compared to standard pain relief.
Xi'an, ShaanxiAges 18–75 - NCT06736106Recruiting
Spine surgery recovery markers study
This trial looks at how certain markers of bone and muscle health might predict complications after spinal surgery. It could help doctors better understand which patients are at risk and improve recovery.
BolognaAges 18 years+ - NCT07737912Enrolling by invitation
SpinePal app for spine fusion recovery
This study tests a smartphone app called SpinePal along with a wrist fitness tracker to help you recover after spine fusion surgery. If you qualify, you'll use the app and tracker for a few months to see if they improve your recovery and reduce pain.
Lebanon, New HampshireAges 18 years+ - NCT07174349RecruitingPhase 4
Medication to prevent urine retention after spine surgery
This trial tests whether a medication called tamsulosin can prevent or shorten the time you need a urinary catheter after spine surgery. It is for people having specific types of neck or lower back surgery.
Rochester, MinnesotaAges 35 years+ - NCT06119542Recruiting
GlycOrtho: Endothelial damage in major spine surgery
This study looks at how major spine surgery affects the inner lining of blood vessels. It measures a substance called syndecan-1 in the blood to understand this damage.
Bologna, BOAges 12–75 - NCT07517679RecruitingPhase 4
Methadone for Pain After Spine Surgery
This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.
Lexington, KentuckyAges 18–120 - NCT03883022Recruiting
Vancomycin powder plus bone graft to prevent spine surgery infection
This trial tests whether placing vancomycin powder and your own bone graft during spine fusion surgery can lower the chance of infection after surgery. It’s meant for people having instrumented spine fusion after other treatments haven’t helped.
TaipeiAges 20 years+ - NCT04646707Recruiting
Nerve block to reduce opioid use after neck spine surgery
This trial tests whether a targeted back/neck numbing injection (an erector spinae block) can help reduce the amount of opioid pain medicine needed after posterior cervical spine surgery. It also aims to support an “enhanced recovery” pathway so patients may recover more comfortably and potentially faster.
Toronto, OntarioAges 18–80 - NCT04855838Recruiting
Study of swallowing problems after neck spine surgery
This study looks at how swallowing recovers after surgery on the front of the neck spine after a trauma. Some people may also be followed more closely if a swallowing test shows a problem a few weeks after surgery.
UmeåAges 18 years+ - NCT06143813Recruiting
Precision treatment for lumbar nerve pain with targeted block
This trial tests if a targeted nerve root injection can improve outcomes for people with persistent leg pain from a compressed nerve in the lower back, with the goal of tailoring surgery more precisely.
Aarhus CAges 18 years+ - NCT06361459Recruiting
Quit Smoking Before Spine Surgery
This study tests whether a program to help people quit smoking before spine surgery improves recovery. It's for adults having neck or low back surgery, but not for cancer or trauma cases.
Leiden, South HollandAges 18–75 - NCT06367855RecruitingPhase 4
Dexamethasone before spine surgery for pain control
This study tests whether giving a single dose of the steroid dexamethasone before minimally invasive spine surgery can help reduce pain and inflammation afterward. It is for people aged 50–80 who are having surgery on 1 or 2 levels of their lower back and have not had spine surgery before.
Pathum Thani, Changwat Pathum ThaniAges 50–80 - NCT06540885RecruitingPhase 4
Comparing two nausea drugs for scoliosis spine surgery
This trial compares two medications, palonosetron and granisetron, to see which is better at preventing nausea and vomiting after spine surgery for scoliosis. These drugs may help you feel less sick after your operation.
Pantai Valley, Kuala LumpurAges 10 years+ - NCT06570577Recruiting
Nerve block for pain after cervical spine surgery
This trial tests whether a nerve block can reduce the need for opioid pain medication after back-of-neck spine surgery. It may help patients have better pain control with fewer side effects.
Stony Brook, New YorkAges 18–75 - NCT06704906Recruiting
Spine fusion surgery with a new bone graft material
This study tests a new bone graft material (Fibergraft BG Putty) used with a special screw system (Viper Prime) during spine fusion surgery. It is for adults with lower back problems who need 1 to 3 vertebrae fused, and who are not smokers or have a very low bone density.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06917300Recruiting
Virtual reality to reduce pain and anxiety before spine surgery
This trial tests if using virtual reality before surgery can help reduce pain and anxiety in people having elective spine surgery. If you're scheduled for spine surgery and speak Polish, you may be able to participate.
Lodz, Łódź VoivodeshipAges 25–70 - NCT07325812Recruiting
Lung opening maneuvers during spine surgery
This study tests whether periodic lung opening maneuvers during back surgery can reduce lung collapse and improve breathing mechanics. Doctors will use ultrasound to monitor your lungs.
IstanbulAges 18–65 - NCT02314988RecruitingPhase 2/Phase 3
Tranexamic acid to reduce bleeding in spine surgery
This trial tests whether tranexamic acid (a medicine that helps blood clot) can reduce blood loss during long spine surgery after an injury. It may help lower the chance of needing transfusions and manage surgical bleeding.
San Francisco, CaliforniaAges 18–80 - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75
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Common questions
- Are there clinical trials for spine surgery?
- Yes. Clin2 currently lists 90 recruiting spine surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spine surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spine surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.