Clinical trials
Squamous Cell Carcinoma clinical trials
Below are recruiting squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 872 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05446467RecruitingPhase 2
Pembrolizumab before surgery for advanced head and neck cancer
This trial studies whether pembrolizumab, given before surgery, can improve outcomes for certain people with stage III–IVA head and neck squamous cell cancer. It’s typically added alongside low-dose PFAS as part of treatment leading up to standard surgery and afterward medicines/radiation.
Qingdao, ShandongAges 18–85 - NCT06628570Recruiting
Screening methods for anal cancer in high-risk adults
This study is looking at ways to screen for anal cancer in people who are at higher risk, such as those with weakened immune systems or a history of abnormal cells in the lower genital tract. It aims to find better methods for early detection.
Miami, FloridaAges 30–80 - NCT06607406Recruiting
Timing of radiation after surgery for head and neck cancer
This study tests whether starting radiation therapy more than 6 weeks (but within 16 weeks) after surgery is safe and effective for people with certain high-risk head and neck cancers. It could help those who had to delay radiation for recovery or other reasons.
Charlotte, North CarolinaAges 18 years+ - NCT06601309RecruitingPhase 2
Study of treatments before surgery for esophageal cancer
This trial is testing different treatment combinations before surgery for people with locally advanced esophageal squamous cell carcinoma. The goal is to find which approach works best based on specific biomarkers like PD-L1 levels.
Fuzhou, FujianAges 18–75 - NCT06597565RecruitingPhase 2
ACR-368 plus low-dose gemcitabine for advanced head and neck cancer
This study tests a new combination of two drugs, ACR-368 and low-dose gemcitabine, for people with head and neck cancer that has come back or spread. The goal is to see if this treatment can help when immunotherapy or other therapies haven't worked.
Tampa, FloridaAges 18 years+ - NCT06563362RecruitingPhase 2
Personalized radiation for oropharyngeal cancer
This trial tests a personalized approach to radiation therapy for oropharyngeal cancer. The goal is to safely reduce the amount of radiation to healthy lymph nodes, which may lower side effects while still effectively treating the cancer.
Zurich, Canton of ZurichAges 18 years+ - NCT06563479RecruitingPhase 3
Personalized vs. standard radiation for HPV-positive throat cancer
This trial compares a personalized, shorter course of radiation therapy to the standard longer course for people with HPV-positive throat cancer. The goal is to see if personalized treatment is just as effective while reducing side effects.
Hartford, ConnecticutAges 18 years+ - NCT04098146Recruiting
Registry for jawbone reconstruction after jaw cancer and jaw bone death
This study collects real-world information from people undergoing jaw reconstruction after their jaw bone was damaged (from cancer and certain medicines). It may help improve future treatment planning by tracking surgical choices and outcomes.
Jacksonville, FloridaAges 18 years+ - NCT06479070Recruiting
Using ctDNA to guide radiotherapy for head and neck cancer
This study looks at whether measuring a DNA fragment in the blood (called ctDNA) can help predict how well radiotherapy works for head and neck cancer. It may help doctors better tailor treatment for patients with stage III or IV disease.
Caen, CaenAges 18 years+ - NCT06487403Recruiting
Delaying radiation for head and neck cancer: MRI and immune markers study
This study tests whether delaying radiation therapy can help doctors learn more from MRI scans and immune system changes in patients with head and neck cancer. This could lead to better treatment decisions.
Toronto, OntarioAges 18 years+ - NCT06476067Recruiting
Predicting early esophageal cancer return after surgery
This trial uses stored tumor tissue to try to predict if esophageal cancer will come back early after surgery. It is for people who had surgery only (no chemo or radiation) and have been followed for at least 2 years.
Nagoya, Aichi-kenAges 20 years+ - NCT06385080RecruitingPhase 1/Phase 2
Study of amivantamab for head and neck cancer
This trial tests a drug called amivantamab, either alone or with other treatments, for people with head and neck cancer that has spread or come back. The goal is to see if the drug can help shrink tumors or control the cancer.
La Jolla, CaliforniaAges 18 years+ - NCT05582122RecruitingPhase 2
Tracking HPV16 DNA in blood to spot cancer coming back
This study checks whether a blood test for HPV16 DNA can predict when HPV-related throat cancer comes back after treatment. It may help improve follow-up care by catching recurrence earlier.
Saint-Denis, La RéunionAges 18 years+ - NCT06367257Recruiting
App to improve nutrition during head and neck cancer radiation
This study tests whether a smartphone app (Emento) can help people with head and neck cancer track and improve their nutrition during and after radiation therapy. The goal is to see if using the app makes it easier to eat well and stay healthy during treatment.
Erlangen, BavariaAges 18 years+ - NCT06358469Recruiting
Vulvar cancer surgery guided by HPV and p53 testing
This trial is for people with early-stage vulvar cancer that can be surgically removed. It looks at the cancer's HPV and p53 status to decide how much tissue to remove, aiming to reduce side effects while keeping the cancer away.
Kelowna, British ColumbiaAges 18 years+ - NCT06336941Recruiting
Ultrasound of the tongue for oral cancer
This study is testing a new way to take pictures of the tongue using a special ultrasound probe that goes inside the mouth. The goal is to see how well this method can show tumor details before surgery.
PisaAges 18 years+ - NCT06256588RecruitingPhase 3
Dostarlimab vs placebo after chemoradiation for head and neck cancer
This study tests whether the immunotherapy drug dostarlimab, given after standard chemoradiation, can keep advanced head and neck cancer from coming back. It is for people who have not had surgery and whose tumors are PD-L1 positive.
Jonesboro, ArkansasAges 18 years+ - NCT06208826RecruitingPhase 2
Immunotherapy maintenance after surgery for head and neck cancer
This trial looks at whether continuing immunotherapy can help keep cancer from coming back in people with head and neck cancer who had a good response to chemo-immunotherapy before surgery. You would have already had surgery, and now the study tests a maintenance treatment to strengthen your immune system's fight against any remaining cancer cells.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06160557Enrolling by invitation
Radiation after endoscopic surgery for superficial esophageal cancer
This trial tests if adding radiation therapy after endoscopic surgery (ESD) helps people with early-stage esophageal cancer that had certain high-risk features, like deeper invasion or positive margins. It aims to improve outcomes for those who didn't get a complete cure with surgery alone.
Fuzhou, FujianAges 18–75 - NCT04370587RecruitingPhase 1/Phase 2
Injecting a cancer medicine into tumors plus pembrolizumab
This Phase 1/2 study tests a medicine injected directly into a tumor, alone or with pembrolizumab (an immune-therapy drug given through a vein). It is for people with advanced or metastatic solid cancers that have grown despite standard treatments, aiming to improve tumor control.
Gilbert, ArizonaAges 18 years+ - NCT06137274RecruitingPhase 2
Adaptive radiation boost for head and neck cancer
This trial tests a new way of giving radiation therapy, called adaptive radiation boost, for people with head and neck cancer. The goal is to see if this approach can better target the cancer and possibly improve outcomes.
Tampa, FloridaAges 18 years+ - NCT06085781Recruiting
MRI and tumor study for head and neck cancer patients
This trial uses special MRI scans to look at your head, neck, and tumor environment before treatment. It aims to find better ways to understand your cancer and guide care.
Toronto, OntarioAges 18 years+ - NCT06052839RecruitingPhase 2
Pulsed chemo plus pembrolizumab for head and neck cancer
This trial tests a new way to give chemotherapy (pulsed doses) together with pembrolizumab (an immunotherapy) for people with head and neck cancer that has come back or spread and cannot be cured with local treatments. The goal is to see if this combination works better than standard approaches.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06050707RecruitingPhase 2
MRI-guided radiation therapy for anal cancer
This trial tests a new, more precise type of radiation therapy for anal cancer. It uses daily MRI scans to adjust the radiation dose based on how the tumor shrinks, aiming to give stronger treatment to the cancer while protecting healthy tissue.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for squamous cell carcinoma?
- Yes. Clin2 currently lists 872 recruiting squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.