Clinical trials
TKA clinical trials
Below are recruiting tka clinical trials, each written for real people, not researchers. We’re tracking 53 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06943053Recruiting
Waterproof bandage study for knee replacement recovery
This study compares two types of waterproof bandages used after total knee replacement surgery to see which one works better at keeping the wound dry and clean.
Pathum Thani, Khlong luangAges 55 years+ - NCT05936593Recruiting
Compare two knee implant positions during robotic knee replacement
This study compares how a knee implant’s components “fit” and move when placed in two different ways during robotic knee replacement. It uses special imaging to see which placement works best for stability and long-term performance.
Zoetermeer, South HollandAges 18–70 - NCT06608745Recruiting
Computer-assisted vs standard knee replacement study
This trial compares a computer-assisted technique to the standard method for total knee replacement. It aims to see if the computer-assisted approach leads to better clinical and functional outcomes.
BolognaAges 45 years+ - NCT07124494Recruiting
Anesthesia type and recovery after knee replacement
This study compares two types of anesthesia for total knee replacement to see which helps with pain, movement, and satisfaction after surgery. If you are scheduled for a knee replacement and are willing to have a spinal or epidural anesthesia, you may be able to join.
Konya, MeramAges 18 years+ - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT05461651Recruiting
Preventing knee infections after knee replacement
This study looks at ways to lower the risk of infection after knee replacement surgery (with or without vancomycin, an antibiotic). If you’re a good candidate, you may receive an approach aimed at preventing post-surgery infections and related complications.
Otwock, Masovian VoivodeshipAges 40 years+ - NCT05823727Recruiting
Collagen supplement study before and after knee replacement
This study tests whether taking collagen peptides can improve how knee tissues heal and remodel after total knee arthroplasty (knee replacement). It also looks at functional recovery and wound healing, especially during the physical therapy period in Little Rock.
Little Rock, ArkansasAges 50–75 - NCT05977036Recruiting
Biomarker test to guide early treatment for HR+ HER2- breast cancer
This study uses a lab “biomarker” test to help doctors choose the best first treatment for people with HR+ (hormone-receptor positive), HER2-negative metastatic or unresectable breast cancer. The goal is to see if this biomarker-guided approach can improve which therapy you start with.
St Louis, MissouriAges 18 years+ - NCT06267482RecruitingPhase 4
Using a robot for knee replacement surgery
This trial tests if a robot-assisted device (ROSA) helps with challenging knee replacements. It compares it to the standard surgery for people with mild knee bowing who need a first-time knee replacement.
London, OntarioAges 21–80 - NCT06298721Recruiting
Personalized care to improve knee replacement satisfaction
This study tests a personalized approach to knee replacement surgery designed for people who are at higher risk of being dissatisfied after the procedure. The goal is to see if tailoring care based on patient-reported outcomes can improve satisfaction.
Cleveland, OhioAges 18–80 - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT06388122Recruiting
Blood test study for HR+ breast cancer treatment monitoring
This study looks at a blood test (DiviTum TKa) to see how well it measures treatment response in people with hormone receptor-positive (HR+) breast cancer that has spread. The test may help doctors know if a treatment is working.
Jacksonville, FloridaAges 18 years+ - NCT06522620Recruiting
Nerve block for knee pain after total knee replacement
This trial tests whether a nerve block can reduce pain on the back and outer side of the knee after total knee replacement surgery. If effective, it may help you recover more comfortably.
Yinchuan, NingxiaAges 45–80 - NCT06600815Recruiting
Step-by-step numbing shots for pain relief in knee replacement
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
Fuzhou, FujianAges 18 years+ - NCT06608992RecruitingPhase 4
Studying a powder to reduce bleeding in knee replacement
This trial tests a powder called SURGICEL® that may help control bleeding during knee replacement surgery. People with severe knee arthritis who are having their first knee replacement may be able to join.
Beijing, Beijing MunicipalityAges Any age - NCT06627673Recruiting
A new knee implant study for severe arthritis
This study compares a new plastic-and-metal knee implant to a standard metal one for people with severe knee arthritis. If you need a total knee replacement and your knee is not too bent or twisted, you may be a candidate.
Leawood, KansasAges 18 years+ - NCT04968964Recruiting
Monitoring test for CDK4/6 drugs in metastatic breast cancer
This study follows people with hormone receptor–positive, HER2-negative metastatic breast cancer who are taking CDK4/6 inhibitor treatment (with or without an added blood test called DiviTum®). The goal is to see how well the standard treatment is working and whether DiviTum® (a serum TK1 activity test) can help guide monitoring.
St Louis, MissouriAges 18 years+ - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT07140523RecruitingPhase 2
Testing a new blood thinner for knee replacement surgery
This study tests a new injection called SRSD107 to see if it prevents blood clots after knee replacement surgery, compared to a standard blood thinner (enoxaparin). It might be an option if you are having a planned knee replacement and are otherwise healthy.
Nové Město na MoravěAges 60–80 - NCT07226076RecruitingPhase 3
Methadone for knee replacement pain and less opioids
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Charleston, South CarolinaAges 18–75 - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07347821Recruiting
Study of osteoarthritis in hip and knee replacement patients
This study looks at why osteoarthritis happens in the hip and knee by studying tissue samples taken during joint replacement surgery. If you are already scheduled for a first-time hip or knee replacement and have osteoarthritis, you may be able to join.
Ostrów Mazowiecka, Masovian VoivodeshipAges 18 years+ - NCT07367789Recruiting
Predicting recovery after knee replacement using smart insoles
This study uses special insoles to measure how you walk before and after a knee replacement. The goal is to see if these measurements can help predict how well you will recover after surgery.
Yongin-si, Gyeonggi-doAges 19 years+ - NCT07386600Recruiting
Comparing two drugs for knee replacement pain relief
This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
PoznanAges 65–100
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Common questions
- Are there clinical trials for tka?
- Yes. Clin2 currently lists 53 recruiting tka studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tka trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tka trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.