Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 961 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05841628Recruiting
Testing a 532-nanometer laser for port wine stain comfort
This study tests how tolerable (comfortable and safe) a specific 532-nanometer laser treatment is for people with non-facial port wine stains. If you join, you’ll get laser sessions and have skin photos taken, while avoiding other treatments on the same area.
Boston, MassachusettsAges 18–75 - NCT05847465Recruiting
Testing body heat regulation after heat stroke in soldiers
This study looks at how well the body controls temperature during exercise after a past heat-stroke episode, in a military setting. It may help improve safety and recovery plans for people who have had exercise-related heat stroke.
Brétigny-sur-OrgeAges 18 years+ - NCT05873322Recruiting
Study glucose changes during steroid and asparaginase treatment
This study looks at how blood sugar changes in children and teens receiving treatment for ALL (a leukemia) or lymphoma. It focuses specifically on effects that may be caused by steroids and a medicine called PEG-asparaginase.
Aarhus NAges 1–17 - NCT05876312RecruitingPhase 1/Phase 2
Study drug ADX-038 in healthy people and PNH patients
This early-stage study tests how safe and tolerable ADX-038 is, and how the body processes it, in healthy volunteers and in people with paroxysmal nocturnal hemoglobinuria (PNH). It may help researchers understand whether the drug works safely for PNH patients and identify the right dosing.
Brisbane, QueenslandAges 18 years+ - NCT05877430RecruitingPhase 1/Phase 2
Testing an anti-cancer drug plus pembrolizumab for advanced cancers
This Phase 1/2 study tests the safety and early signs of benefit from CJRB-101 when combined with pembrolizumab (Keytruda) in people with advanced or metastatic lung, head and neck, or melanoma cancer. It may help some participants, but the main goal is to see how safe the combination is and whether it can control cancer.
Irvine, CaliforniaAges 18 years+ - NCT05892614RecruitingPhase 2
Efzofitimod for early systemic sclerosis lung scarring
This trial tests efzofitimod to see if it can improve or slow lung disease caused by systemic sclerosis (scleroderma), and to check safety and side effects. It focuses on people with relatively early disease and measurable lung involvement on lung scans.
Los Angeles, CaliforniaAges 18 years+ - NCT05903027Recruiting
Testing gepant migraine treatment for better side effects
This trial studies how well a “gepant” medicine works for different types of migraine and how tolerable it is. It may help if you have frequent migraines and you can keep a headache diary as the study asks.
FlorenceAges 18 years+ - NCT05904093RecruitingPhase 1
Check if increasing fostamatinib doses are safe in sickle cell
This Phase 1 study tests whether increasing doses of fostamatinib are safe and tolerated in adults with stable sickle cell disease. It may help researchers understand if the drug could be a future treatment option for people with stable sickle cell.
Bethesda, MarylandAges 18–65 - NCT05911828RecruitingPhase 1
Oral malaria pill study in adults without symptoms
This Phase 1 study tests how safe a combination oral medicine (ZY19489 with ferroquine) is in adults who carry malaria in their blood but have no symptoms. It also studies how the body absorbs and processes the medicines.
LambarénéAges 18–55 - NCT05912348Recruiting
Study of how an unhealthy lifestyle affects active young adults
This study looks at how eating or daily habits that promote weight gain (“obesogenic” lifestyle) affect fitness and health markers in young adults who already exercise. It may help researchers understand what lifestyle changes matter most, and whether certain patterns affect active people differently.
Durham, New HampshireAges 18–30 - NCT05924295Recruiting
Study how ketone changes in the body with diet and fasting
This study looks at how your body processes “ketones,” which are energy molecules that rise with fasting or low carbohydrate intake. You may be asked to follow strict diet and activity rules before test days so researchers can see what affects ketone metabolism.
Novato, CaliforniaAges 20–70 - NCT05936346Recruiting
Check safety of a Salvia extract dietary supplement
This trial tests whether a Salvia-based extract (taken like a dietary supplement) is safe and well-tolerated in generally healthy adults. It also checks whether people can follow the study diet and activity routines during the trial.
LuganoAges 55–65 - NCT05936710Recruiting
Citrate vs acetate dialysis to prevent low blood pressure
This study compares two types of dialysis fluid (citrate-based vs acetate-based) to see which better helps protect blood pressure during intermittent dialysis. It may help people in intensive care who are at risk of dialysis-related low blood pressure.
BéthuneAges 18 years+ - NCT05942625RecruitingPhase 1
Study of an experimental drug in healthy adults
This Phase 1 trial tests how safe and tolerable an experimental medicine (HS-10390) is in healthy adults, and how the body processes it. It is not for people with an illness, but for healthy volunteers to help researchers understand the drug before future studies.
Nanjing, JiangsuAges 18–45 - NCT05954312RecruitingPhase 1
Study of an experimental drug for advanced solid tumors
This Phase 1 trial tests VVD-130037, a new experimental medicine, to see if it is safe and tolerable in people with advanced (metastatic or unresectable) solid cancers. If you have already tried standard treatments and your body can handle study medication, you may be eligible—especially for certain lung, head and neck, or esophageal cancer types with specific genetic changes.
Jacksonville, FloridaAges 18 years+ - NCT05989958RecruitingPhase 1/Phase 2
HepaCure for acute-on-chronic liver failure
This trial tests a new treatment called HepaCure for people with acute-on-chronic liver failure (a sudden worsening of liver function in someone with long-term liver disease). The goal is to see if it is safe and can help improve liver function.
Beijing, Beijing MunicipalityAges 18–65 - NCT05995782RecruitingPhase 1
Testing safety of FB418 in healthy people
This trial studies a new drug called FB418 to see if it's safe and how the body handles it. It first tests single doses in younger healthy men, then multiple doses, and also includes an optional group for healthy older adults.
SeoulAges 19 years+ - NCT06003153RecruitingPhase 4
Gene and sugar response study with oral semaglutide
This study looks at how your genes affect your body's response to a diabetes medication called semaglutide. It may help people with slightly high blood sugar (pre-diabetes) understand why some respond better than others.
Boston, MassachusettsAges 18–65 - NCT06024421RecruitingPhase 1
Testing high doses of favipiravir in healthy volunteers
This study tests the safety and how the body processes very high doses of the antiviral drug favipiravir in healthy people. It helps find the highest dose that is still safe before testing in patients.
ParisAges 18–75 - NCT06043193Recruiting
Quality of life study for patients with neuroendocrine tumors getting internal radiation therapy
This study looks at how internal radiation therapy (RIV) affects quality of life in people with neuroendocrine tumors. It aims to understand how well patients tolerate this treatment and how it impacts daily life.
Saint-Priest-en-Jarez, Saint-EtienneAges 18 years+ - NCT06053619Recruiting
Virtual reality walking rehab for stroke patients who cannot walk
This trial tests whether adding virtual reality to robot-assisted walking therapy helps people who have had a stroke and cannot walk. It is for patients who had a first stroke in the past 15 days to 6 months.
LimogesAges 35–75 - NCT06055361RecruitingPhase 1
Studying a new injection for moderate to severe eczema
This trial tests an investigational drug called BxC-I17e, given as an injection under the skin, for people with moderate to severe atopic dermatitis (eczema) that hasn't improved enough with standard creams. The goal is to see if it is safe and works well.
North Little Rock, ArkansasAges 18 years+ - NCT06078683Recruiting
Ketone drink for exercise and heart health in type 2 diabetes
This study tests whether a special ketone drink can improve exercise ability and heart function in people with type 2 diabetes. Participants will have two treadmill exercise tests and heart MRI scans to see how the drink affects their performance and cardiac efficiency.
Columbus, OhioAges 18–80 - NCT06084052Recruiting
Mobile app study to prevent foot ulcers in diabetes
This trial tests a mobile app to help prevent foot ulcers in people with diabetes who are at high risk. You will use the app to track your foot health and get advice to keep your feet safe.
LondonAges 18–100
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 961 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.