Clinical trials
Transdiagnostic clinical trials
Below are recruiting transdiagnostic clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06909669Recruiting
Brief therapy for anxiety, depression, or physical symptoms
This study tests short-term psychological treatments to help people with mild or moderate emotional symptoms like anxiety, depression, or physical complaints (such as pain or fatigue) that may be linked to stress. The goal is to see if these brief therapies can improve how you feel.
Córdoba, CórdobaAges 18 years+ - NCT07738081Enrolling by invitation
Testing a new therapy for substance use and emotional health
This trial is testing a new type of therapy (the Unified Protocol) that helps people who are in treatment for substance use and also have depression or anxiety. The goal is to see if this approach can improve emotional well-being and reduce substance use.
OviedoAges 18 years+ - NCT06433271Recruiting
Therapy study for adjustment disorder after trauma
This study compares a new type of talk therapy (Transdiagnostic Behavior Therapy) to standard care for veterans and active military members who are struggling with adjustment disorder after a traumatic event. The goal is to see which approach helps people feel better and adjust to life after trauma.
Charleston, South CarolinaAges 18 years+ - NCT07483333Recruiting
Comparing two group therapies for kids with medical conditions and trauma
This study compares two types of group therapy for youth ages 8–18 who have a chronic medical condition and trauma-related distress. The goal is to see which type of group helps kids feel better and handle their health challenges.
Chicago, IllinoisAges 8–18 - NCT06724666Recruiting
Online therapy for teens with anxiety or depression
This study tests an online therapy program for teens aged 13–17 who feel anxious, depressed, or both. The program is designed to help you understand and manage these feelings through short, internet-based sessions, and you can do it from home.
Cluj-NapocaAges 13–17 - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06937892Recruiting
Metacognitive therapy vs. Cognitive therapy for anxiety
This study compares two different types of therapy for anxiety disorders: metacognitive therapy (which focuses on how you think about your thoughts) versus cognitive-behavioral therapy (which works on changing thoughts and behaviors). It may help you find which approach works best for you.
StockholmAges 18 years+ - NCT06804954Recruiting
Online CBT vs. usual care for mild mental health issues
This study tests an online CBT program (cognitive behavioral therapy you do from home) versus usual care for people with mild to moderate anxiety, depression, or stress. It aims to help you manage symptoms before they become more serious.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT06804941Recruiting
Online CBT vs. usual care for common mental health issues
This study tests whether online cognitive behavioral therapy (CBT) works better than usual care for people with common mental health issues like anxiety, depression, or stress. If eligible, you would receive a guided online program from your computer or phone, without needing to visit a clinic.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06384196Recruiting
Virtual-reality therapy for anxiety and depression in young people
This study tests a new virtual-reality therapy for young people struggling with anxiety or depression. It aims to help you feel better by addressing both conditions together.
BadalonaAges 16–29 - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT05986604Recruiting
Improving Sleep and Daily Rhythms for Older Adults
This study tests a treatment that helps improve sleep and daily rhythms, which may also help with memory and moving around. It's for people aged 50+, with low income, who have trouble with mobility and sleep.
Berkeley, CaliforniaAges 50 years+ - NCT05825040Recruiting
Testing an online mental health program for anxiety and depression
This trial tests an “online” mental health approach to help people with moderate to severe anxiety and/or depression. If you qualify, you may be invited to use the program and share feedback as part of a study.
Shatin, N.T.Ages 17 years+ - NCT04463498Recruiting
Sleep school program for insomnia alongside mental health problems
This trial tests a group “sleep school” program to improve sleep when insomnia happens together with moderate to severe mental health symptoms. It may help you learn practical sleep strategies and improve sleep quality while you’re getting psychiatric care.
BergenAges 18–80 - NCT06289621Recruiting
Brief treatment for anxiety and PTSD in South Africa
This trial tests a short, talk-based therapy for people with anxiety disorders or PTSD. It aims to help you manage symptoms in fewer sessions.
Cape TownAges 18–65 - NCT07433491Recruiting
Blue-blocking glasses for sleep problems in teens
This study tests if blue-blocking glasses can help teenagers with sleep problems like insomnia or delayed sleep phase, which are linked to mental health conditions. You would wear the glasses in the evening for a short period to see if they improve your sleep.
Haugesund, RogalandAges 12–18 - NCT07382323Recruiting
Comparing two talk therapies for anxiety and PTSD
This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.
StockholmAges 18 years+ - NCT07346014Recruiting
Sleep therapy for college students at risk of suicide
This study tests if improving sleep can help college students who are already getting mental health treatment for suicidal thoughts. You will try light therapy or sleep schedule changes to see if it reduces suicide risk.
Pittsburgh, PennsylvaniaAges 18–25 - NCT06858540Recruiting
Blended therapy for teens who self-harm
This trial tests a type of talk therapy to help teens who have hurt themselves on purpose (non-suicidal self-injury). It mixes in-person sessions with online tools to teach better coping skills and reduce self-harm.
Changsha, HunanAges 12–17 - NCT06778096Recruiting
Online therapy for anxiety and depression in new moms
This trial tests an online therapy program for new moms who feel anxious or depressed. It uses cognitive-behavioral therapy (CBT) through a computer or tablet to help you manage your mood.
Châteauguay, QuebecAges 18 years+ - NCT06315114Recruiting
Parenting support therapy for mental health
This study tests a talking therapy that helps parents with mental health challenges to better understand and connect with their child. It is designed for parents who are already getting help for conditions like anxiety, PTSD, or personality disorders.
Gentofte Municipality, Capital RegionAges 18–65 - NCT06963463Recruiting
Sleep & light therapy for teens with depression
This study tests a program that combines sleep and light therapy to help teens with depression and sleep problems feel better. It focuses on improving your sleep schedule and adding bright light exposure to boost mood.
Philadelphia, PennsylvaniaAges 12–18 - NCT06777693Enrolling by invitation
Unified Protocol for emotional disorders in older adults
This study tests a group therapy program for older adults with anxiety or depression. The program teaches skills to manage difficult emotions and improve emotional well-being.
Bergen, VestlandAges 65 years+
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Common questions
- Are there clinical trials for transdiagnostic?
- Yes. Clin2 currently lists 44 recruiting transdiagnostic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transdiagnostic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transdiagnostic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.