Clinical trials
Transdiagnostic clinical trials
Below are recruiting transdiagnostic clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06804954Recruiting
Online CBT vs. usual care for mild mental health issues
This study tests an online CBT program (cognitive behavioral therapy you do from home) versus usual care for people with mild to moderate anxiety, depression, or stress. It aims to help you manage symptoms before they become more serious.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT06804941Recruiting
Online CBT vs. usual care for common mental health issues
This study tests whether online cognitive behavioral therapy (CBT) works better than usual care for people with common mental health issues like anxiety, depression, or stress. If eligible, you would receive a guided online program from your computer or phone, without needing to visit a clinic.
Gustavsberg, Stockholm CountyAges 18 years+ - NCT07738081Enrolling by invitation
Testing a new therapy for substance use and emotional health
This trial is testing a new type of therapy (the Unified Protocol) that helps people who are in treatment for substance use and also have depression or anxiety. The goal is to see if this approach can improve emotional well-being and reduce substance use.
OviedoAges 18 years+ - NCT05825040Recruiting
Testing an online mental health program for anxiety and depression
This trial tests an “online” mental health approach to help people with moderate to severe anxiety and/or depression. If you qualify, you may be invited to use the program and share feedback as part of a study.
Shatin, N.T.Ages 17 years+ - NCT05986604Recruiting
Improving Sleep and Daily Rhythms for Older Adults
This study tests a treatment that helps improve sleep and daily rhythms, which may also help with memory and moving around. It's for people aged 50+, with low income, who have trouble with mobility and sleep.
Berkeley, CaliforniaAges 50 years+ - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT06384196Recruiting
Virtual-reality therapy for anxiety and depression in young people
This study tests a new virtual-reality therapy for young people struggling with anxiety or depression. It aims to help you feel better by addressing both conditions together.
BadalonaAges 16–29 - NCT06433271Recruiting
Therapy study for adjustment disorder after trauma
This study compares a new type of talk therapy (Transdiagnostic Behavior Therapy) to standard care for veterans and active military members who are struggling with adjustment disorder after a traumatic event. The goal is to see which approach helps people feel better and adjust to life after trauma.
Charleston, South CarolinaAges 18 years+ - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06724666Recruiting
Online therapy for teens with anxiety or depression
This study tests an online therapy program for teens aged 13–17 who feel anxious, depressed, or both. The program is designed to help you understand and manage these feelings through short, internet-based sessions, and you can do it from home.
Cluj-NapocaAges 13–17 - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06937892Recruiting
Metacognitive therapy vs. Cognitive therapy for anxiety
This study compares two different types of therapy for anxiety disorders: metacognitive therapy (which focuses on how you think about your thoughts) versus cognitive-behavioral therapy (which works on changing thoughts and behaviors). It may help you find which approach works best for you.
StockholmAges 18 years+ - NCT07382323Recruiting
Comparing two talk therapies for anxiety and PTSD
This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.
StockholmAges 18 years+ - NCT06465381Recruiting
Suicide prevention program for teens in Mozambique schools
This trial tests a safety planning and therapy program to help teens with suicidal thoughts. It is for students in certain schools in Mozambique.
BeiraAges Any age - NCT06858540Recruiting
Blended therapy for teens who self-harm
This trial tests a type of talk therapy to help teens who have hurt themselves on purpose (non-suicidal self-injury). It mixes in-person sessions with online tools to teach better coping skills and reduce self-harm.
Changsha, HunanAges 12–17 - NCT06623682Recruiting
Online mental health support for university students
This trial tests a self-help program with support services for students in Hong Kong who are experiencing moderate to severe anxiety or depression. It aims to see if these tools can improve mental health.
Hong KongAges 18 years+ - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT05561595Recruiting
Reducing health-related stigma through group support
This trial tests a virtual group program to help people cope with health-related stigma from conditions like obesity, cancer, HIV, diabetes, skin disease, or chronic pain. It aims to reduce internalized stigma and improve well-being.
Gainesville, FloridaAges 18 years+ - NCT06631729Recruiting
Interoceptive exposure app for binge eating disorders
This study tests a smartphone app that helps you notice and cope with body signals linked to binge eating. It is for adults with binge eating disorder or bulimia nervosa who want to try a new digital treatment.
Minneapolis, MinnesotaAges 18–64 - NCT04463498Recruiting
Sleep school program for insomnia alongside mental health problems
This trial tests a group “sleep school” program to improve sleep when insomnia happens together with moderate to severe mental health symptoms. It may help you learn practical sleep strategies and improve sleep quality while you’re getting psychiatric care.
BergenAges 18–80 - NCT04793828Recruiting
Self-guided online program for certain anxiety disorders
This trial tests “Velibra,” a self-guided online program to help people with anxiety disorders while they are waiting for care. It focuses on panic, social anxiety, and generalized anxiety, and may help by teaching coping skills through lessons and questionnaires.
BerlinAges 18–65 - NCT04864080Recruiting
Online study to measure brain-related signals in pain or depression
This trial uses an online study platform to look for “cognitive biomarkers,” which are measurable patterns in thinking or brain-related responses. It compares people with pain or depression to healthy controls to see how these patterns differ and could help future research or care.
Minneapolis, MinnesotaAges 18 years+ - NCT05289258Recruiting
Barlow-style program for thinking and memory problems after breast cancer
This trial tests a structured “Barlow Protocol” program to help improve mild to moderate thinking and memory problems in people who finished breast cancer chemotherapy. It may help if your cognitive symptoms started after treatment and you’re not already in similar therapy.
CórdobaAges 18–70 - NCT05427708Recruiting
Breathing training to reduce anxiety symptoms
This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.
Austin, TexasAges 18 years+
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Common questions
- Are there clinical trials for transdiagnostic?
- Yes. Clin2 currently lists 44 recruiting transdiagnostic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transdiagnostic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transdiagnostic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.