Treatment
Comparator clinical trials
We’re tracking 1,754 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT05696626RecruitingPhase 3
Test a new pill plus abemaciclib versus standard therapy
This Phase 3 study compares lasofoxifene plus abemaciclib versus fulvestrant plus abemaciclib for ER-positive, HER2-negative breast cancer that has an ESR1 mutation. It looks for better tumor control in people whose cancer has progressed on hormone therapy (an aromatase inhibitor) and who meet specific safety and testing requirements.
Scottsdale, ArizonaAges 18 years+ - NCT05699928Recruiting
Testing how well pediatricians spot autism in young children
This study compares an early autism opinion made by a community general pediatrician with a more detailed team assessment. It may help improve how families get autism evaluations sooner and more accurately.
Toronto, OntarioAges birth–5.3 years - NCT05704582Recruiting
Avatar vs supportive sessions to cut cannabis use
This study compares two types of talking/learning sessions—one using an “avatar” (computer-based character) and one using regular supportive sessions—to reduce cannabis use. It is meant for adults with psychotic disorders who also meet criteria for cannabis use disorder.
Montreal, QuebecAges 18 years+ - NCT05727904RecruitingPhase 3
New immunotherapy for advanced melanoma, with or without lifileucel
This trial studies whether adding lifileucel (a patient-specific immune-cell treatment) to pembrolizumab works better than pembrolizumab alone. It’s for people with untreated advanced melanoma that cannot be removed by surgery.
Birmingham, AlabamaAges 18–70 - NCT05729542Recruiting
Suture button vs Fibulink for acute ankle ligament injury
This study compares two different surgical devices used to fix a torn ankle ligament (called the syndesmosis) after an ankle fracture. If you may need surgery for this specific injury, the results could help show which device leads to better recovery.
San Diego, CaliforniaAges 18 years+ - NCT05730036RecruitingPhase 3
Linvoseltamab vs standard treatment for relapsed myeloma
This trial compares linvoseltamab against a standard combination (elotuzumab + pomalidomide + dexamethasone) in adults with multiple myeloma that has returned or not responded. It aims to find out whether linvoseltamab works better and is safe for people who have already had some myeloma treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Escondido, CaliforniaAges 18 years+ - NCT05738525Recruiting
Compare two types of home dialysis for kidney outcomes and quality of life
This study compares two forms of home peritoneal dialysis—how well they work for kidney health and how they affect daily life. You may be considered if you have end-stage kidney disease and meet specific test and safety requirements.
Beijing, Beijing MunicipalityAges 18–75 - NCT05744466Recruiting
Compare two psoriasis medicines using real-world patient data
This study looks at how well two common plaque psoriasis medicines—deucravacitinib and apremilast—work in everyday care. It may help researchers understand which option performs better in real patients outside of a traditional drug trial.
Waltham, MassachusettsAges 18 years+ - NCT05754593Recruiting
Study ovarian reserve in women with multiple sclerosis
This study compares egg supply (“ovarian reserve”) in women with multiple sclerosis to women without MS. It may help doctors understand how MS affects reproductive health and egg supply.
BordeauxAges 25–35 - NCT05762198Recruiting
Rezūm vs TURP for blocked urine from enlarged prostate
This study compares two procedures—Rezūm (water vapor therapy) and TURP (a surgery)—for men whose urine blockage is not improving. The goal is to see which option works better and is safer for relieving urinary retention due to an enlarged prostate.
Hong KongAges 50–80 - NCT05764057RecruitingPhase 3
Dapagliflozin to help the heart heal after a heart attack
This trial tests whether dapagliflozin (a diabetes medicine also used for heart protection) can reduce harmful heart “remodeling” after an acute heart attack. It may help your heart function and structure recover over the following 6 months.
ParisAges 18 years+ - NCT05766410RecruitingPhase 2
Testing three CDK4/6 pills to change the immune response
This phase 2 trial compares ribociclib, palbociclib, and abemaciclib to see how each one affects your body’s immune response in estrogen- and/or progesterone-receptor–positive, HER2-negative early breast cancer. If you fit the stage and health requirements, joining could help doctors learn which treatment best “modulates” the immune system.
TaipeiAges 20 years+ - NCT05768503RecruitingPhase 3
Test new drugs after colorectal cancer chemotherapy
This Phase 3 trial compares a new treatment combination (chidamide plus sintilimab plus bevacizumab) versus the standard second-line chemotherapy (FOLFIRI plus bevacizumab) for advanced colorectal cancer that is microsatellite stable/low. It aims to see which treatment works better and is safer for people whose cancer grew after first-line oxaliplatin-based therapy.
Hefei, AnhuiAges 18–75 - NCT05774678RecruitingPhase 3
Pre-surgery radiation options for invasive breast cancer
This trial compares two schedules of radiation given before mastectomy to see which works better for invasive breast cancer, followed by immediate breast reconstruction. It also studies tiny “biomarker” signals in tissue to learn why one radiation approach may help more.
Houston, TexasAges 18 years+ - NCT05779462Recruiting
MRI study for suspected pelvic endometriosis
This trial is for people who have symptoms that might be caused by endometriosis and are being referred for a pelvic MRI. It uses MRI (a scan) to help doctors better understand suspected pelvic endometriosis.
LilleAges 18–50 - NCT05780710Recruiting
Smartphone blood pressure monitor tested for people with high BP
This study compares an optical blood pressure monitor (used like a home device with a smartphone) against standard home blood pressure readings. It’s meant to see if the new device gives accurate results for people with high blood pressure who are not currently on blood pressure medicines.
Geneva, Canton of GenevaAges 21–85 - NCT05781295Recruiting
Taurolidine vs saline lock for kids’ central line
This trial studies whether a medicine lock called taurolidine is safer or works better than a standard saline (salt water) lock for pediatric cancer patients with central venous lines. It’s meant to help prevent central-line infections.
ParisAges Up to 21 years - NCT05786417RecruitingPhase 4
Medication comparison for older adults with stable heart pain
This trial tests which heart medications work best for older adults who have stable angina (predictable chest pain) and multiple other long-term health problems. You may be asked to start or adjust medications and attend regular follow-up visits to see which approach controls symptoms and outcomes.
New Haven, ConnecticutAges 65 years+ - NCT05786742Recruiting
Radiation plan test for early prostate cancer with a boost
This trial tests a more concentrated radiation schedule for early-stage prostate cancer, using an extra high-dose “boost” delivered from inside the body. It may help by treating the prostate more precisely while aiming to keep side effects manageable.
QuébecAges 18–95 - NCT05797649Recruiting
Test a pleural fluid blood marker to tell heart failure vs others
This study checks whether a substance called NT-proBNP in pleural fluid can better identify if fluid around the lung is caused by heart failure. If you fit, the results may help doctors choose faster, more accurate diagnosis for your pleural effusion.
Hong Kong, New TerritoriesAges 18 years+ - NCT05826158Recruiting
Scans compared for children with neuroblastoma
This trial compares two different nuclear medicine scans to see which one best shows where neuroblastoma is in a child’s body. The results may help doctors choose the most helpful scan for planning care.
CopenhagenAges Up to 18 years - NCT05828030Recruiting
High-flow oxygen with a face interface versus nasal mask
This trial compares two ways of giving oxygen to people with serious breathing problems after chest trauma. It looks to see whether a high-flow system works better when delivered through a face interface rather than a facial mask, after standard nasal oxygen fails within 72 hours.
Taipei, TaipeiAges 20–99 - NCT05834855RecruitingPhase 3
Rituximab versus ocrelizumab for relapsing multiple sclerosis
This Phase 3 trial compares two similar immune therapies—rituximab and ocrelizumab—to see if rituximab works about as well for relapsing multiple sclerosis. It may help you and researchers understand which option is equally effective and safe for preventing relapses and disease activity.
AmsterdamAges 18 years+
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,754 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.