Treatment
Comparator clinical trials
We’re tracking 1,702 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT03785743Recruiting
Compare keyhole vs open surgery for pancreatic cancer
This trial compares two ways of doing surgery for pancreatic cancer: keyhole (small cuts) versus open surgery (one larger cut). It’s meant to see which approach works better for people who are well enough for either option.
Wuhan, HubeiAges 18–75 - NCT03158090Recruiting
Study of treatment patterns for acromegaly over time
This study follows people with acromegaly to better understand how treatments are used in real life and how well they work over time. It may help improve future treatment choices by comparing outcomes across different care patterns.
Guangzhou, GuangdongAges 18–75 - NCT05292742RecruitingPhase 2
Continue targeted breast cancer therapy or switch to a new combo
This Phase 2 study compares two treatment plans after breast surgery when cancer did not fully disappear before surgery. It tests whether adding trastuzumab, pyrotinib, and capecitabine works better than continuing the original targeted therapy.
Fuzhou, FujianAges 18–75 - NCT05469659RecruitingPhase 2
Test drug to slow kidney damage in type 2 diabetes
This Phase 2 study compares tofogliflozin to metformin to see how well they reduce urine albumin levels (a marker of kidney stress) in people with diabetic kidney disease. You might benefit if your type 2 diabetes is affecting your kidneys despite standard blood-pressure medicines.
Matsumoto, NaganoAges 20 years+ - NCT05401357RecruitingPhase 3
Test eye drops for glaucoma or high eye pressure in both eyes
This Phase 3 study compares two versions of the same glaucoma eye-drop medicine (bimatoprost 0.01%) to see how similarly they work and their effect on eye pressure. It may help people with chronic open-angle glaucoma or ocular hypertension who need treatment in both eyes.
Newport Beach, CaliforniaAges 18 years+ - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT05642338Recruiting
Testing two sampling methods to monitor Barrett’s esophagus
This study compares two ways of taking tissue samples during endoscopy to check how Barrett’s esophagus is changing. The goal is to improve surveillance, especially for finding early precancer or early cancer changes.
Amsterdam, North HollandAges 18 years+ - NCT05661305Recruiting
Egyptian healthy adults for heart and MRI study
This trial studies how healthy hearts work in Egyptian adults who do not have known heart problems. It may help researchers understand heart health and risk factors, using an MRI scan.
AswānAges 18 years+ - NCT05366452Recruiting
Early heart pump implant for shock after a heart attack
This trial studies whether putting in a small heart pump early (through the leg) helps people with a heart attack complicated by severe heart weakness (“cardiogenic shock”) compared with standard treatment. It aims to improve survival and recovery by supporting blood flow sooner.
Marseille, Bouche DU RhoneAges 18–80 - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT05740397Recruiting
Testing blood pressure targets during heart-lung bypass
This trial compares different strategies for keeping a specific blood pressure level during heart-lung bypass surgery. It may help reduce complications by finding the safest blood pressure target during the operation.
VeronaAges 18–80 - NCT05768503RecruitingPhase 3
Test new drugs after colorectal cancer chemotherapy
This Phase 3 trial compares a new treatment combination (chidamide plus sintilimab plus bevacizumab) versus the standard second-line chemotherapy (FOLFIRI plus bevacizumab) for advanced colorectal cancer that is microsatellite stable/low. It aims to see which treatment works better and is safer for people whose cancer grew after first-line oxaliplatin-based therapy.
Hefei, AnhuiAges 18–75 - NCT05255471RecruitingPhase 3
Olaparib after surgery for recurrent ovarian cancer
This trial tests whether olaparib (a pill cancer medicine) works better than standard platinum chemotherapy after a second surgery for recurrent ovarian cancer. It’s for people whose cancer returned after initial PARP-inhibitor (PARPi) maintenance and aims to see if treatment can control the cancer for longer with acceptable side effects.
NaplesAges 18 years+ - NCT04944615Recruiting
IVUS-guided stent placement for blocked heart artery using longer guidance
This trial compares two ways to place a stent (a small mesh tube) for a completely blocked heart artery: using an IVUS camera inside the artery versus using a standard x-ray approach. It may help people get better heart outcomes by improving how accurately the stent is placed in long-term blockages.
BeijingAges 18 years+ - NCT05813015RecruitingPhase 3
Testing S-1 after stomach cancer surgery with or without sequence therapy
This Phase 3 study compares two ways of giving S-1 medicine after curative stomach cancer surgery in stage III disease. It aims to see whether the sequential approach improves outcomes while keeping treatment safe.
Hanzhou, ZhejiangAges 18–75 - NCT05486546Recruiting
Compare two LASIK mapping methods for myopia and astigmatism
This trial compares two ways of mapping your eye to guide LASIK surgery for people with nearsightedness and mild astigmatism. It looks at how well vision (especially best-corrected vision) does after surgery one month later.
Bozeman, MontanaAges 21–38 - NCT05834855RecruitingPhase 3
Rituximab versus ocrelizumab for relapsing multiple sclerosis
This Phase 3 trial compares two similar immune therapies—rituximab and ocrelizumab—to see if rituximab works about as well for relapsing multiple sclerosis. It may help you and researchers understand which option is equally effective and safe for preventing relapses and disease activity.
AmsterdamAges 18 years+ - NCT05681689RecruitingPhase 3
Check how well a urea breath test works after H. pylori treatment
This Phase 3 study tests whether a urea breath test can confirm that H. pylori infection has been cleared after recent treatment. If the test works well, it may help doctors confirm cure without needing invasive procedures.
Doral, FloridaAges 18 years+ - NCT05231343Recruiting
Dual small-plate vs single plate for broken collarbones
This trial compares two surgical plate methods to fix a broken collarbone in the middle part (midshaft). The goal is to see which method works better for healing and function after an acute, fully displaced fracture.
Toronto, OntarioAges 18–65 - NCT04183608RecruitingPhase 4
Telemonitoring and education to guide treatment for ulcerative colitis
This trial tests whether “treat-to-target” care—guided by regular symptom checks, telemonitoring, and patient education—works better than standard follow-up when starting adalimumab for ulcerative colitis. It aims to help control inflammation more effectively and reduce flare-ups.
Cholet, Maine Et LoireAges 18–75 - NCT04581447RecruitingPhase 3
Metformin to help prevent diabetes returning after weight surgery
This Phase 3 study tests whether adding metformin after gastric bypass or sleeve surgery can help you stay free of diabetes for longer. It compares metformin plus standard care versus standard care alone.
AmiensAges 18–70 - NCT05738525Recruiting
Compare two types of home dialysis for kidney outcomes and quality of life
This study compares two forms of home peritoneal dialysis—how well they work for kidney health and how they affect daily life. You may be considered if you have end-stage kidney disease and meet specific test and safety requirements.
Beijing, Beijing MunicipalityAges 18–75 - NCT05931263RecruitingPhase 3
Tested Chi-BEAM vs BEAM before stem cell transplant for lymphoma
This Phase 3 study compares two chemotherapy schedules (Chi-BEAM vs BEAM) given before an autologous stem cell transplant to treat newly diagnosed peripheral T-cell lymphoma that responded to first-line treatment. If you fit the lab and heart/lung requirements, it may offer access to a new treatment approach designed to improve outcomes.
Nanjing, JiangsuAges 18–65 - NCT05956639RecruitingPhase 3
Rezvilutamide with ADT and chemo: shorter versus longer treatment
This Phase 3 trial compares two lengths of rezvilutamide treatment when given with hormone therapy (ADT) and chemotherapy for men with advanced prostate cancer. It aims to find which treatment duration works best and is safest to help control the cancer.
Nanjing, JiangsuAges 18 years+
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,702 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.