Treatment
Ketamine clinical trials
We’re tracking 154 recruiting studies that include Ketamine, each written for real people, not researchers, below.
Recruiting studies
- NCT05097261RecruitingPhase 4
Ketamine for adults with severe brain injury in the ICU
This trial studies whether ketamine can improve outcomes for adults with severe traumatic brain injury when they are in the ICU and need sedation. It focuses on patients who have pressure monitoring inside the brain soon after admission.
BonheidenAges 18 years+ - NCT05156060RecruitingPhase 1/Phase 2
Gabapentin and ketamine to treat head and neck cancer pain
This early-phase study tests whether gabapentin and a ketamine nasal spray can help prevent or lessen short-term and long-term pain from locally advanced head and neck cancer. It may help by changing how the nervous system responds to pain during and after radiation and chemoradiation.
Nashville, TennesseeAges 21 years+ - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05378555RecruitingPhase 3
Oral ketamine for sickle cell pain crises
This trial tests whether taking ketamine by mouth can help treat “vaso-occlusive” pain episodes that may require hospital admission. If it works, it could offer an easier way to manage severe pain during sickle cell crises.
Boston, MassachusettsAges 12–24 - NCT05450432RecruitingPhase 4
Ketamine maintenance to help prevent suicidal thoughts
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
Boston, MassachusettsAges 18–70 - NCT05737693RecruitingPhase 2
Ketamine plus weekly therapy for severe PTSD
This study tests whether adding ketamine to a structured, one-week psychological therapy program can reduce severe PTSD symptoms. It may help people who have had PTSD for a long time and still feel very affected.
New Haven, ConnecticutAges 21–70 - NCT05786066RecruitingPhase 2
Test whether blocking AMPA changes ketamine’s suicide relief
This study looks at whether an “AMPA receptor blocker” changes how ketamine affects suicidal thoughts in people with depression that hasn’t improved with usual treatments. If you qualify, you may receive ketamine and the study medicine, while continuing your regular mental health care.
West Haven, ConnecticutAges 21–65 - NCT05821972RecruitingPhase 4
Breathing-mist medicines for cleft palate surgery pain control
This trial tests whether a breathing mist of two medicines (dexmedetomidine plus ketamine) works better than dexmedetomidine alone during cleft palate repair surgery. It may help improve comfort and safety around anesthesia for eligible patients.
AsyutAges 1–4 - NCT05915013RecruitingPhase 1
Brain-targeting study of ketamine response in treatment-resistant depression
This early-stage study looks at how parts of brain cells respond to ketamine in people with depression who have not improved with usual antidepressants. It may help researchers find why ketamine works for some people and not others, and who might benefit.
New Haven, ConnecticutAges 18–60 - NCT05934669RecruitingPhase 4
Numbing medicines compared for small stitches in young children
This trial tests three medicines given through the nose to keep children comfortable during minor procedures in the emergency department, specifically for closing small cuts with stitches. It may help find which nasal medicine works best and is safest for quick, minimal procedures.
Oklahoma City, OklahomaAges 1–5 - NCT05940324RecruitingPhase 2
Ketamine study for OCD after prior treatment failed
This Phase 2 study tests how ketamine may work quickly in people with obsessive-compulsive disorder (OCD), especially after at least one standard treatment didn’t help. If you join, you’ll need to follow study procedures like fasting before the experimental visit and not enrolling in other medication trials during the study.
Stanford, CaliforniaAges 18–65 - NCT06038409Recruiting
Ketamine therapy for chronic conditions
This trial tests if ketamine can help people with long-term health issues. It aims to find new treatments for chronic conditions that haven't responded well to other therapies.
Helena, MontanaAges 18 years+ - NCT06062628RecruitingEarly Phase 1
Ketamine for severe traumatic brain injury
This study tests whether a low dose of ketamine can help people with severe traumatic brain injury by reducing brain pressure and improving oxygen levels. If you have a brain monitor in place and meet safety criteria, you may be able to join.
Dallas, TexasAges 18 years+ - NCT06070766Recruiting
At-home ketamine study for chronic conditions
This trial tests a ketamine protocol you can use at home. It may help if you have a long-term health condition.
Bigfork, MontanaAges 18 years+ - NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT06125054RecruitingPhase 2
Ketamine and brain training for cocaine addiction
This trial tests whether a combination of ketamine (a medicine that may help the brain change) and neurofeedback training (a brain-exercise technique) can help people with cocaine addiction. The goal is to see if these treatments can improve brain flexibility and reduce cravings.
Zurich, Canton of ZurichAges 18–55 - NCT06140927RecruitingPhase 3
Ketamine's effect on spinal monitoring during back surgery
This study tests if giving ketamine during certain back surgeries affects how well doctors can monitor your spinal nerves during the operation. It's for adults having a posterior spinal fusion.
San Francisco, CaliforniaAges 18–100 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06231563RecruitingPhase 2
Ketamine for depression in veterans with Parkinson's
This study tests if ketamine can help treat depression in veterans with Parkinson's disease. It involves several in-person and remote visits, and you will need to avoid certain medications and cannabis for a short time before and during some visits.
San Francisco, CaliforniaAges 40–80 - NCT06272461Recruiting
Comparing lidocaine vs. ketamine for colorectal surgery pain
This trial compares two pain-relief medicines (lidocaine vs. ketamine) given through an IV during open colorectal surgery. It aims to find which one works better to reduce pain after surgery.
NabeulAges 18–90 - NCT06278779RecruitingPhase 4
Comparing two types of ketamine for stubborn depression
This study compares two forms of ketamine to see which works better for depression that hasn't improved with at least two other antidepressants. If you've tried multiple antidepressants without success, this trial might help find a more effective treatment.
Camperdown, New South WalesAges 18 years+ - NCT06284473RecruitingPhase 4
Ketamine with numbing medicine for minor emergency procedures
This study tests whether adding ketamine to the usual numbing medicine makes minor procedures in the emergency department less painful. You may be a good fit if you are having a small procedure like stitches or abscess drainage.
Maywood, IllinoisAges 7–70 - NCT06364540RecruitingPhase 4
Ketamine vs fentanyl for severe pain in the ER
This trial compares two inhaled pain relievers, ketamine and fentanyl, to see which works better for sudden, severe pain in the emergency room. You would receive one of these medicines through a breathing mask to help your pain quickly.
Brooklyn, New YorkAges 18–120
Common questions
- Are there clinical trials studying Ketamine?
- Yes. Clin2 currently lists 154 recruiting studies that include Ketamine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Ketamine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Ketamine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Ketamine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.