Treatment
L-citrulline clinical trials
We’re tracking 10 recruiting studies that include L-citrulline, each written for real people, not researchers, below.
Recruiting studies
- NCT06312748RecruitingPhase 1
Improving blood vessels in veterans with heart failure
This test is looking at whether certain medications (like statins) can help improve blood vessel health in veterans who have heart failure with preserved pumping function. It may help reduce symptoms and keep you out of the hospital.
Salt Lake City, UtahAges 18 years+ - NCT04513288Recruiting
Immunonutrition with L-citrulline for ICU sepsis patients
This trial tests whether adding L-citrulline to tube feeding (enteral nutrition) can improve outcomes for people in the ICU with sepsis or septic shock. It may help support the body’s immune response while you’re critically ill.
Rennes, Brittany RegionAges 18 years+ - NCT05259904RecruitingPhase 2
L-citrulline supplement for deployment-related asthma symptoms
This trial studies whether an L-citrulline supplement can improve asthma control in people who developed persistent asthma symptoms after military deployment. If you qualify, you may be asked to track symptoms and breathing test results to see if the supplement helps.
Denver, ColoradoAges 18–70 - NCT06426147Recruiting
Citrulline for hospitalized children with fever
This trial tests if L-citrulline, a natural substance, can help young children (1 month to 5 years) who are hospitalized with fever and are at moderate to high risk for severe illness. It aims to improve their recovery and reduce complications.
HararAges birth–5 years - NCT06635902RecruitingPhase 2
Citrulline for sickle cell pain crisis
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Washington D.C., District of ColumbiaAges 4–21 - NCT07617909RecruitingPhase 2
L-Citrulline vs. Tamsulosin for Kidney Stone Passage
This study tests whether L-citrulline (a natural amino acid) or tamsulosin (a common blood pressure medication) helps you pass a small kidney stone stuck in your ureter (the tube from kidney to bladder) without surgery. The goal is to compare which medicine works better and is safer.
Banī Suwayf, Beni Suweif GovernorateAges 18–60 - NCT07642505RecruitingPhase 4
L-Citrulline and Tadalafil for Mild Erectile Dysfunction
This study tests whether two compounds—L-citrulline (a natural amino acid) and tadalafil (a common erectile dysfunction medication)—work well together for men with mild to moderate erectile problems. The goal is to see if this combination safely improves sexual function.
Banī Suwayf, Beni Suweif GovernorateAges 30–70 - NCT03885245RecruitingPhase 2
L-citrulline supplement for overweight adults with later-onset asthma
This Phase 2 trial tests whether adding L-citrulline can improve asthma control in overweight adults whose asthma started later in life. It compares your asthma symptoms and lung testing results to see if the supplement helps when asthma is already being treated.
Durham, North CarolinaAges 18–65 - NCT05636397Recruiting
Oral L-citrulline for fragile preterm babies with lung or bowel disease
This trial studies whether an oral medicine called L-citrulline (L-cit) is safe and how it works in very preterm infants. It includes two groups: babies with chronic lung disease (with or without high blood pressure in the lungs) and babies recovering from severe bowel infection (NEC).
Toronto, OntarioAges 1 month–6 months - NCT05934318Recruiting
Arginine supplements to help prevent pregnancy complications
This study tests whether taking an arginine-based supplement during pregnancy can help lower the risk of bad pregnancy outcomes. You may be eligible if you are pregnant in the early-to-mid period and meet safety and location requirements.
KisumuAges 16–40
What L-citrulline is being studied for
Conditions with recruiting L-citrulline studies.
Common questions
- Are there clinical trials studying L-citrulline?
- Yes. Clin2 currently lists 10 recruiting studies that include L-citrulline, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a L-citrulline trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is L-citrulline an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether L-citrulline or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.