Treatment
Melatonin clinical trials
We’re tracking 66 recruiting studies that include Melatonin, each written for real people, not researchers, below.
Recruiting studies
- NCT07442162Enrolling by invitationPhase 1/Phase 2
Melatonin for excessive crying in newborns
This trial tests if melatonin can help reduce excessive crying in otherwise healthy newborns. It may offer a safe option for babies who cry for more than 3 hours a day on more than 3 days a week.
Mosul, Nineveh GovernorateAges 2 weeks–4 weeks - NCT07375693Enrolling by invitationPhase 2
Melatonin for Parkinson's patients on levodopa
This trial tests if adding melatonin can reduce oxidative stress (a kind of cell damage) in people with mild to moderate Parkinson's disease who are already taking levodopa. It aims to see if melatonin helps protect the brain and improve symptoms.
Dhaka, Dhaka DivisionAges 45–85 - NCT07316582Enrolling by invitationPhase 4
Melatonin gel for gum disease treatment
This trial tests a new gel made with melatonin and platelet-rich fibrin to treat gum disease. It may help reduce pocket depth and improve gum health without surgery.
New CairoAges 20–60 - NCT07169383Enrolling by invitationPhase 2
Melatonin vs. tranexamic acid for melasma
This study compares two oral treatments—melatonin and tranexamic acid—to see which works better for reducing melasma. Both are pills you take by mouth, and the goal is to find a safe, effective option for people with this skin condition.
Islamabad, Punjab ProvinceAges 18–50 - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05107947Recruiting
Dynamic room lighting to improve sleep and daily body rhythm
This study tests whether changing the light in a hospital room can improve sleep and help your body clock work better in older adults. It may be most helpful if sleep problems or irregular daily rhythms are affecting you in the hospital.
MalmöAges 65 years+ - NCT03438526RecruitingPhase 4
Melatonin treatment for low-activity delirium in ICU patients
This trial tests whether giving melatonin (or a placebo) can help adults in the intensive care unit who have a specific type of confusion called low-activity delirium. It aims to improve recovery by supporting sleep–wake regulation in the ICU.
BaselAges 55 years+ - NCT05617833RecruitingPhase 1
Test EPO and melatonin for brain bleeding in very preterm babies
This Phase 1 trial studies whether giving erythropoietin (EPO) and melatonin is safe in very preterm infants who have bleeding in the brain (intraventricular hemorrhage) or significant nearby brain injury. It aims to see if these medicines can be given safely during the early days after birth.
St. Petersburg, FloridaAges 12 hours–2 months - NCT06816225Recruiting
Sleep and Baby Development in Early Childhood
This study looks at how sleep might be linked to a baby's development, like how they move and learn. Researchers will follow healthy babies born at term to see if sleep patterns affect their growth over time.
PortoAges 2–4 - NCT07554716Recruiting
Timing of Tube Feeding and Body Rhythms
This study looks at how the timing of tube feeding (enteral nutrition) throughout the day affects your body's natural sleep and wake cycles. Researchers want to understand if adjusting when you receive nutrition might help improve your sleep and overall health.
Málaga, MálagaAges 18 years+ - NCT07336277RecruitingPhase 3
Sleep quality study for hospitalized orthopedic trauma patients
This study tests if a special sleep program can help people with leg or foot injuries sleep better in the hospital. It may show if treatments like zolpidem or melatonin help improve sleep after surgery.
Atlanta, GeorgiaAges 18–65 - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT06226025RecruitingPhase 2
Melatonin for Bipolar Disorder in Night Owls
This trial tests whether giving melatonin at the right time can help people with bipolar disorder who are night owls improve their mood and sleep. You would take melatonin or a placebo each evening for a few weeks while tracking your symptoms on a phone app.
Ann Arbor, MichiganAges 18–60 - NCT06236932Recruiting
Infection risk in obesity study
This study looks at how obesity and related conditions affect your body's ability to fight infections. It may help find ways to prevent illness in people with obesity.
NaplesAges 18–65 - NCT06509191RecruitingPhase 2/Phase 3
Melatonin for preventing delirium in older hospital patients
This trial tests if giving melatonin (a natural sleep hormone) can help prevent delirium (sudden confusion) in older adults who are hospitalized. It may help you if you are 65 or older and admitted to the hospital for general medical care.
MuscatAges 65 years+ - NCT06600633Recruiting
Melatonin supplement for better sleep quality
This trial tests whether a melatonin supplement can improve sleep quality in people with mild sleep issues. It may help if you have poor sleep but not full insomnia.
LjubljanaAges 24–65 - NCT06687304Recruiting
Lighting effects on radiographers in hospitals
This trial studies how lighting in a hospital environment affects radiographers. It aims to understand if different lighting designs can improve comfort, well-being, or performance at work.
Lund, Skåne CountyAges 21 years+
Common questions
- Are there clinical trials studying Melatonin?
- Yes. Clin2 currently lists 66 recruiting studies that include Melatonin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Melatonin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Melatonin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Melatonin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.