Treatment
Melatonin clinical trials
We’re tracking 66 recruiting studies that include Melatonin, each written for real people, not researchers, below.
Recruiting studies
- NCT05084196RecruitingPhase 3
Melatonin to help prevent kidney damage from vancomycin
This Phase 3 study tests whether melatonin can help protect the kidneys in people who are starting or continuing vancomycin, an antibiotic that can sometimes affect kidney function. If you qualify, you would take melatonin as an added prevention step while you’re on vancomycin.
New Brunswick, New JerseyAges 18–75 - NCT05247125RecruitingPhase 4
Testing light or melatonin to help brain recovery after stroke
This study looks at whether changing your sleep timing using light therapy or melatonin can improve “brain rewiring” after an ischemic stroke. It mainly focuses on people who arrive very soon after stroke symptoms and who also meet specific safety and sleep/medication requirements.
Saint PetersburgAges 18–80 - NCT05474846RecruitingPhase 2/Phase 3
Combination treatment to improve sleep in advanced cancer
This trial tests a combination approach to improve poor sleep in people with advanced cancer. If you qualify, you would answer sleep and symptom questions and may do a structured therapy (CBT) plus follow-up visits.
Houston, TexasAges 18 years+ - NCT05502900RecruitingPhase 3
Melatonin after eye melanoma to lower spread risk
This Phase 3 study tests whether taking melatonin after treatment for uveal melanoma can reduce the chance that the cancer returns or spreads to other parts of the body. It is aimed at people with higher-risk eye melanoma features.
Stockholm, Stockholm CountyAges 18 years+ - NCT05651347RecruitingPhase 3
Melatonin in pregnancy to protect babies with slow growth
This trial studies whether taking melatonin during pregnancy can help protect the baby’s brain and organs in cases of poor fetal growth. It focuses on pregnancies at a specific gestational age with signs that the placenta may not be working well.
Camperdown, New South WalesAges 18 years+ - NCT05701969RecruitingEarly Phase 1
Melatonin for sleep during night shifts in residents
This early study tests whether melatonin can improve sleep patterns for doctors-in-training during overnight “night float” shifts. It may help you feel more rested and adjust to night work.
Charlottesville, VirginiaAges 18 years+ - NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT06062953RecruitingPhase 2/Phase 3
Melatonin or low-dose quetiapine for insomnia in psychiatric disorders
This study tests if melatonin, a low dose of quetiapine, or a placebo can help people with a psychiatric condition who also have trouble sleeping. You may qualify if you have insomnia at least 3 times a week and your sleep problem has lasted 3 months or longer.
Copenhagen NVAges 16–64 - NCT06093477Recruiting
Melatonin and recovery for teens after surgery
This study tests whether taking melatonin (a natural sleep hormone) after a major bone or joint surgery helps teens recover better. If you are 12-18 and having a surgery like scoliosis repair, you may be able to join.
Palo Alto, CaliforniaAges 12–18 - NCT06252571RecruitingPhase 2
Melatonin and light therapy for idiopathic hypersomnia
This trial tests whether taking melatonin at night and using a bright light therapy device in the morning can improve excessive daytime sleepiness in people with idiopathic hypersomnia. It is a double-blind study, meaning neither you nor the doctors will know if you are getting the real treatment or a placebo.
StrasbourgAges 18–40 - NCT04588233Recruiting
Melatonin study for teens with sleep trouble
This study tests whether melatonin can help teens (ages 13–17) who have trouble sleeping. You may be able to join if you’ve never taken melatonin before and your sleep issue seems to be behavior-related rather than caused by another medical sleep problem.
Loma Linda, CaliforniaAges 13–17 - NCT06380491RecruitingPhase 4
Melatonin for nighttime blood pressure in sleep apnea
This study tests whether melatonin can help lower nighttime blood pressure and improve sleep quality in people with obstructive sleep apnea who have 'non-dipping' blood pressure (blood pressure that stays high at night).
Mexico CityAges 18–60 - NCT06502613Recruiting
Scoliosis and Sleep Cycle in Children
This study looks at how sleep timing (melatonin levels) might be linked to new cases of scoliosis in children. If you have scoliosis and are between 6 and 15, you may help researchers understand this connection.
Wenzhou, ZhejiangAges 6–15 - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21 - NCT06846086RecruitingPhase 3
Melatonin for heart muscle protection
This trial tests if adding melatonin to standard heart medication helps protect the heart muscle in people with cardiomyopathy. If you are stable on your current heart meds, you may be able to join.
Dakahlia, Egypt, MansouraAges 18 years+ - NCT06949904RecruitingPhase 1/Phase 2
Melatonin as an add-on therapy for childhood pneumonia
This trial tests whether adding melatonin to standard pneumonia treatment helps children recover faster. It is for children aged 1 month to 12 years with pneumonia or severe pneumonia.
Islamabad, IslamabadAges 1 month–12 years - NCT06996171Recruiting
Magnesium and melatonin for insomnia in young adults
This trial compares two natural supplements—magnesium and a melatonin-like compound—to see which works better for helping young adults fall asleep and stay asleep. It is for people with primary insomnia (trouble sleeping without another medical cause).
Kharan, Punjab ProvinceAges 18–40 - NCT07036367RecruitingPhase 4
Melatonin before cataract surgery for older adults
This trial is testing whether a melatonin tablet placed under the tongue before surgery can help older adults feel calmer and more comfortable during cataract surgery. Melatonin is a natural sleep hormone that may reduce anxiety without the side effects of common sedatives.
Cairo, EgyptAges 60 years+ - NCT02621944RecruitingEarly Phase 1
Melatonin for newborns with brain injury after oxygen problems
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
Gainesville, FloridaAges Up to 6 hours - NCT07472075RecruitingPhase 2
Melatonin vs placebo for bipolar disorder
This trial tests whether taking melatonin (a natural sleep hormone) helps stabilize mood in people with bipolar disorder compared to a placebo (a pill with no active ingredient). It may help improve sleep and mood stability.
FrederiksbergAges 18–70 - NCT07542756RecruitingPhase 4
Testing Common Sleep Medications for Insomnia
This study compares how well different over-the-counter and prescription sleep medications work for insomnia. Researchers will guide you through trying medications one at a time to find what works best for your sleep problems.
Philadelphia, PennsylvaniaAges 18–80 - NCT07617922RecruitingPhase 2
Melatonin and solifenacin for ureteral stent discomfort
This study tests whether two medications—melatonin (a sleep aid) and solifenacin (a bladder-control medicine)—can reduce uncomfortable symptoms from a temporary plastic tube (ureteral stent) placed in your urinary system during kidney stone treatment. The goal is to find out if these drugs help you feel better while the stent is in place.
Banī Suwayf, BeniSuefAges 18–60 - NCT07651514Recruiting
Magnesium and Melatonin for Better Sleep and Leg Cramps
This study tests whether taking daily magnesium and melatonin supplements can help improve sleep quality and reduce nighttime leg cramps in adults. You'll wear a special ring to track your sleep and use a smartphone app to log your experiences.
Palm Beach Gardens, FloridaAges 40–75 - NCT07549295Enrolling by invitationPhase 1
Melatonin to help babies grow better in the womb
This study tests whether melatonin (a natural sleep hormone) can help babies who are not growing well in the womb due to placental blood-flow problems. Researchers will measure if melatonin improves the baby's growth and health before delivery.
Shanghai, Shanghai MunicipalityAges 20–43
Common questions
- Are there clinical trials studying Melatonin?
- Yes. Clin2 currently lists 66 recruiting studies that include Melatonin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Melatonin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Melatonin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Melatonin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.