Treatment
Methylprednisolone clinical trials
We’re tracking 94 recruiting studies that include Methylprednisolone, each written for real people, not researchers, below.
Recruiting studies
- NCT06081101RecruitingEarly Phase 1
Comparing two injections for sacroiliac joint pain
This trial compares two types of pain-relieving injections for sacroiliac joint pain. One is a common anti-inflammatory (ketorolac), and the other is a steroid. The goal is to see which works better and lasts longer.
Hamilton, OntarioAges 18 years+ - NCT06040255Enrolling by invitationPhase 4
Steroid treatment for focal brain artery inflammation in children
This trial tests whether short-term steroids improve recovery for children who recently had a stroke or mini-stroke caused by inflammation of a brain artery. If you qualify, you would receive steroids and follow-up imaging to see if it helps prevent further damage.
San Francisco, CaliforniaAges 1–18 - NCT04873583RecruitingPhase 3
High-dose steroids for children after a one-sided stroke
This trial tests whether high-dose steroids given soon after a stroke can improve outcomes for children. It is aimed at children whose stroke is caused by a one-sided blood-vessel problem seen on brain scans.
Randwick, New South WalesAges 6 months–17 years - NCT05925309Recruiting
Oral antibiotics to prevent bile duct inflammation after Kasai surgery
This trial studies whether giving oral antibiotics before symptoms start can lower the chance of cholangitis (bile duct infection/inflammation) after Kasai portoenterostomy. It may help protect your child’s bile flow and reduce painful or serious infections after surgery.
Shanghai, Shanghai MunicipalityAges 2 weeks–3 months - NCT05324748RecruitingPhase 3
Repeated nerve-block shots for chronic cluster headache
This Phase 3 trial tests whether repeated injections can reduce attacks of chronic cluster headache. It may help people who have frequent, consistent attacks and can track them closely during the study.
LeidenAges 18–70 - NCT05867329RecruitingPhase 4
Comparing treatments for severe ulcerative colitis flare-ups
This study compares different sequences of medicines for treating severe ulcerative colitis flares in the hospital. It aims to find the best way to get your symptoms under control and help you feel better faster.
Ann Arbor, MichiganAges 18–75 - NCT05842681Recruiting
Azithromycin for early worsening of idiopathic pulmonary fibrosis
This trial studies whether adding azithromycin to standard care can help people whose idiopathic pulmonary fibrosis is starting to flare up (worsen) in the early stages. It’s mainly for adults who are not very sick and cannot require intensive breathing support.
AsyutAges 18–80 - NCT05734625RecruitingPhase 2
Nerve block injections for episodic migraine pain relief
This Phase 2 trial tests whether nerve block injections can reduce pain from episodic migraines. It may help some people who get frequent migraine attacks but are not also using certain migraine preventions or strong pain medicines.
Rochester, MinnesotaAges 18 years+ - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT05097976RecruitingPhase 4
Medrol tablets to reduce pain after knee replacement
This trial tests whether a short course of Medrol (methylprednisolone) can improve recovery after outpatient total knee replacement done for osteoarthritis. You would be randomly assigned to receive Medrol or a comparison treatment.
Oak Brook, IllinoisAges 18 years+ - NCT05039619RecruitingPhase 2
Obinutuzumab trial for adolescents with active lupus kidney inflammation
This Phase 2 study tests obinutuzumab, a targeted antibody medicine, in teens with active lupus nephritis (inflammation in the kidney). It looks at whether it helps kidney disease and is safe, including how the body handles the drug.
Loma Linda, CaliforniaAges 5–17 - NCT04988256Enrolling by invitationEarly Phase 1
Test cyclosporine versus steroids for DRESS skin reaction
This trial compares two medicines—cyclosporine and steroid treatment—for a rare, serious drug reaction called DRESS. It aims to see which treatment controls the illness more safely and effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT04787744RecruitingPhase 2/Phase 3
Test standard prostate cancer treatment with or without targeted spot radiation
This study tests whether adding targeted local treatment (like radiation to a few spots seen on scans) improves outcomes for some people with limited (oligometastatic) prostate cancer. It compares standard systemic therapy alone versus standard therapy plus PET-scan–guided spot treatment.
Long Beach, CaliforniaAges 18 years+ - NCT04685772Recruiting
Medrol Dose Pack for new concussion headache relief
This trial tests whether a Medrol “dose pack” (a short course of steroid medicine taken by mouth) can reduce acute headache pain after a concussion. It may help people whose concussion headaches are frequent and severe soon after injury.
Manhasset, New YorkAges 18 years+ - NCT04224558RecruitingPhase 1/Phase 2
Stem cell transplant for hard-to-control Crohn’s disease
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Los Angeles, CaliforniaAges 13–28 - NCT04216524RecruitingPhase 2
Venetoclax plus chemotherapy for blastic dendritic cell cancer
This Phase 2 trial tests venetoclax combined with chemotherapy to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN). It may help shrink BPDCN and control the disease, whether you’re newly diagnosed or the cancer has come back.
Houston, TexasAges 18 years+ - NCT03952637RecruitingPhase 1/Phase 2
Gene therapy for GM1 disease with IV delivery
This early-stage study tests an IV gene therapy that delivers a working copy of an enzyme gene to help the body make beta-galactosidase in GM1 gangliosidosis. It may help slow or improve disease symptoms and looks closely at safety and how well the treatment works.
Bethesda, MarylandAges 6 months–12 years - NCT03579875RecruitingPhase 2
Testing an inherited bone marrow transplant approach for rare blood disorders
This Phase 2 study tests a special “T-cell depleted” transplant plan for people with inherited bone marrow failure disorders (Fanconi anemia or T-Beta-thalassemia—or “TBD”). It may help restore healthy blood production while lowering the chance of certain transplant complications.
Minneapolis, MinnesotaAges Up to 65 years - NCT03219359RecruitingPhase 2
Stem cell transplant using your own cells for Crohn’s flare
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
New York, New YorkAges 18 years+ - NCT02784210RecruitingPhase 2
Steroid treatment to reduce inflammation in active MS lesions
This Phase 2 study tests whether corticosteroid medicine can reduce inflammation at the edge of active multiple sclerosis (MS) plaques seen on MRI. It may help calm “hot” areas in the brain where MS activity is happening.
Bethesda, MarylandAges 18–120 - NCT02464696Recruiting
Noninvasive breathing support to avoid tube breathing in cancer
This trial studies a mask-based breathing treatment (noninvasive ventilation) for people with cancer and serious breathing trouble, to see if it can prevent the need for intubation (putting a breathing tube in). If you qualify, the goal is to help you breathe better without invasive airway support when possible.
Houston, TexasAges 18 years+
Common questions
- Are there clinical trials studying Methylprednisolone?
- Yes. Clin2 currently lists 94 recruiting studies that include Methylprednisolone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Methylprednisolone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Methylprednisolone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Methylprednisolone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.