Treatment
Opioid clinical trials
We’re tracking 430 recruiting studies that include Opioid, each written for real people, not researchers, below.
Recruiting studies
- NCT07079215Recruiting
Device trial for opioid withdrawal symptoms
This trial tests a physical device (ADTPM 1) to help manage withdrawal symptoms in people who are dependent on opioids. The goal is to see if the device can safely reduce withdrawal discomfort.
Daegu, DaeguAges 19–80 - NCT07079241Recruiting
Volunteer naloxone responders for opioid overdose emergencies
This trial trains volunteers to give naloxone, a medication that reverses opioid overdoses, using a smartphone app to alert nearby responders. It could help save lives by getting antidote treatment to overdose victims faster.
Malmö, Skåne CountyAges 18 years+ - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06935331Enrolling by invitationPhase 4
Opioid-free spinal fusion for teens with scoliosis
This trial tests a way to manage pain after scoliosis surgery without using opioid medications. It aims to see if patients can recover comfortably using only non-opioid pain relievers, which may help avoid opioid side effects and addiction risks.
Charlotte, North CarolinaAges 10–20 - NCT06837857RecruitingPhase 2
Opioid pain relief study for older adults with chronic pain
This study tests whether a carefully managed prescription opioid can safely help older adults with long-term pain that hasn't been relieved by other pain medicines. The goal is to see if it improves pain without harming memory or brain health.
Rochester, MinnesotaAges 65 years+ - NCT06800703Recruiting
Opioid use, pain, and the brain
This study uses brain scans (MRI) to understand how pain affects people with opioid use disorder or regular opioid use, compared to healthy volunteers. It aims to find better ways to treat both pain and opioid addiction.
New Haven, ConnecticutAges 21–60 - NCT06774248Recruiting
Teen opioid recovery support program with medication
This study tests a program called YORS that helps teens with opioid use disorder stick with their medication. It involves you and a support person (like a parent) working together with the study team to stay on track.
Baltimore, MarylandAges 13–21 - NCT06593353Recruiting
Improving opioid use disorder care for people leaving jail
This study tests a system to improve care for people with opioid use disorder as they leave jail and return to the community. It aims to help patients stay in treatment and avoid interruptions.
Seattle, WashingtonAges 18–110 - NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06559969RecruitingPhase 2/Phase 3
IV vs Epidural Pain Medicine for Open Abdominal Surgery
This trial compares two ways to manage pain after major open abdominal surgery: giving pain medicine through an IV or through an epidural combined with numbing medicine. It aims to find which method works better for patients.
Iowa City, IowaAges 18–85 - NCT06538558RecruitingPhase 1
Study of tezampanel for opioid withdrawal
This trial tests if tezampanel can help relieve withdrawal symptoms in people with opioid use disorder who are seeking treatment. Participants must already be in an outpatient addiction program.
Indianapolis, IndianaAges 18–65 - NCT06526286Recruiting
Support to help you use medications for opioid use disorder
This trial tests if a computer tool can help doctors prescribe medications for opioid use disorder during regular checkups. It may be right for you if you take prescription opioids for pain or have had issues with opioids.
Aurora, ColoradoAges 12–89 - NCT06404983Recruiting
Opioid-free anesthesia for breast cancer surgery
This study tests whether breast cancer surgery can be done safely without using opioid pain medicines during anesthesia. The goal is to see if avoiding opioids leads to fewer side effects and a smoother recovery.
Ioannina, EpirusAges 18–99 - NCT06380244Recruiting
Pain Relief Without Opioids for Abdominal Surgery
This study tests if a completely opioid-free anesthesia approach works as well as standard general anesthesia for people having laparoscopic or robotic urological surgery. It aims to offer effective pain control without using strong opioid painkillers.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT04173416Recruiting
Support program for young adults in opioid recovery
This study tests a structured recovery support program for adults age 18–28 who have opioid use disorder. It may help by adding extra involvement and support while you receive common long-acting opioid treatment from a medical clinic.
Baltimore, MarylandAges 18–28 - NCT06023225Recruiting
Sex hormones, pain, and opioid use in girls after surgery
This study looks at how sex hormones affect pain and the use of pain medicine after orthopedic surgery in girls. It might help explain why some people need more pain relief than others.
St Louis, MissouriAges 11–16 - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05905419Recruiting
Brain scan study of opioid effects in women with pain
This study uses brain imaging (MRI) to understand how opioid medications may affect the brain in women. People with chronic pain who take opioids (or do not) and healthy women without chronic pain may be invited to participate.
Durham, North CarolinaAges 18 years+ - NCT05834478RecruitingPhase 3
Noninvasive vagus nerve stimulation for opioid use disorder
This trial tests whether noninvasive vagus nerve stimulation can help people with opioid use disorder during supervised withdrawal and treatment afterward. It may be considered if you can safely move to medication or behavioral care after withdrawal.
Atlanta, GeorgiaAges 18–75 - NCT05729932RecruitingPhase 1
Cannabis and opioid use disorder study
This Phase 1 trial studies cannabis in people with opioid use disorder. The goal is to better understand how it may affect opioid use disorder, while monitoring safety.
Lexington, KentuckyAges 18–55 - NCT03923374Recruiting
Study of buprenorphine for opioid use during pregnancy
This study looks at pregnancy and baby outcomes for people who are pregnant and taking buprenorphine for opioid use disorder. It may help doctors understand what to expect long-term for both parent and child when opioid treatment continues during pregnancy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04094701Recruiting
Study of opioid needs after hip arthroscopy surgery
This study looks at how much pain medicine (opioids) people actually need after hip arthroscopy and what factors may affect it. It may help improve safer, more personalized pain control after surgery.
Chicago, IllinoisAges 18–80 - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+
Common questions
- Are there clinical trials studying Opioid?
- Yes. Clin2 currently lists 430 recruiting studies that include Opioid, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Opioid trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Opioid an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Opioid or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.