Treatment
Treatment as Usual clinical trials
We’re tracking 317 recruiting studies that include Treatment as Usual, each written for real people, not researchers, below.
Recruiting studies
- NCT04609046RecruitingPhase 1
Lenalidomide and nivolumab added to standard treatment for brain lymphoma
This Phase 1 trial tests adding two cancer medicines—lenalidomide and nivolumab—to the usual treatment for primary CNS diffuse large B-cell lymphoma (a type of lymphoma in the brain/spinal fluid). The goal is to see if the combination is safe and if it works better than the usual approach.
Los Angeles, CaliforniaAges 18 years+ - NCT06203600RecruitingPhase 2/Phase 3
Nivolumab plus standard treatment for advanced stomach or esophageal cancer
This trial tests whether adding the immunotherapy drug nivolumab to standard treatment works better for advanced stomach or esophageal cancer. It is for people whose cancer has already progressed after a first round of chemo plus immunotherapy.
Little Rock, ArkansasAges 18 years+ - NCT06957028Recruiting
CGM for early detection of high blood sugar in pregnancy
This study is testing whether wearing a continuous glucose monitor (CGM) early in pregnancy can help find and manage high blood sugar, which may lower the risk of problems for you and your baby. You would wear a small sensor under your skin, and the device sends information to a smartphone app.
Birmingham, AlabamaAges 18 years+ - NCT05773274RecruitingPhase 2
Retreating with 177Lu-DOTATATE radiation versus usual treatment
This trial tests whether repeating a targeted radioactive treatment (177Lu-DOTATATE) works better than standard options in people with metastatic gastroenteropancreatic neuroendocrine tumors. It may help by controlling tumor growth after the first round of this therapy stops working.
Birmingham, AlabamaAges 18 years+ - NCT07278570Recruiting
Tracking muscle stiffness with MRI during hands-on therapy for low back pain
This study uses a special MRI scan to see if hands-on therapy (manual therapy) helps reduce muscle stiffness and pain in people with chronic low back pain. It aims to find a better way to measure how well this treatment works.
Rochester, MinnesotaAges 18 years+ - NCT06931340RecruitingPhase 3
Adding chemo to hormone therapy for advanced prostate cancer
This trial is for men with metastatic prostate cancer that has already spread beyond the pelvis. It tests whether adding a chemotherapy drug (docetaxel) to the usual hormone therapy plus apalutamide can help control the cancer better than hormone therapy alone.
Tucson, ArizonaAges 18 years+ - NCT04840602RecruitingPhase 2
Venetoclax plus rituximab versus standard Waldenstrom treatment
This trial tests whether adding venetoclax to rituximab works better than standard treatment options for Waldenstrom’s macroglobulinemia (WM). It’s for adults whose WM needs treatment and who meet specific blood, organ, infection, and medication safety requirements.
Tucson, ArizonaAges 18 years+ - NCT04671667RecruitingPhase 2
Pembrolizumab vs chemo-radiation after surgery for recurrent head/neck cancer
This trial tests whether pembrolizumab (an immunotherapy drug) works better than the usual chemo plus radiation after surgery for cancer that has come back in the head and neck area. It may help reduce cancer returning or spreading by using your immune system, but eligibility depends on how the cancer came back and your prior treatments.
Birmingham, AlabamaAges 18–79 - NCT06290141RecruitingPhase 3
Testing riliprubart vs. standard IVIg for CIDP
This trial tests whether a new medication called riliprubart works as well as the usual IVIg treatment for people with chronic inflammatory demyelinating polyneuropathy (CIDP). It may offer another option for managing your condition.
Homewood, AlabamaAges 18 years+ - NCT05408845RecruitingPhase 2
Study drug vs standard care for HER2 salivary gland cancer
This Phase 2 trial tests how well ado-trastuzumab emtansine (and compares to two standard treatment options) works for salivary gland cancers that are HER2-positive or HER2-low. It aims to see whether the study drug can control cancer better and with acceptable side effects.
Birmingham, AlabamaAges 18 years+ - NCT05534438RecruitingPhase 2
Tested targeted radiation plus usual drug treatment in metastatic breast cancer
This Phase 2 study tests whether adding a very focused type of radiation to standard drug treatment can better control metastatic breast cancer. It is for people whose cancer is only progressing in one spot, seen on a PET scan.
Basking Ridge, New JerseyAges 18 years+ - NCT05624996RecruitingPhase 3
Targeted high-dose radiation added to standard lung cancer treatment
This trial tests whether adding high-dose, targeted radiation to the usual treatment helps people with locally advanced, non-operable lung cancer live longer or better control the cancer. It may help shrink tumors in the chest and improve outcomes when surgery can’t be done.
Birmingham, AlabamaAges 18 years+ - NCT06234176Recruiting
Psychomotor therapy for quality of life in depression
This study tests whether a special type of therapy called psychomotor therapy (which focuses on the connection between your mind and body) can improve quality of life for people with severe depression. You’ll continue your usual care while also receiving this therapy, and the researchers will track how your mood and daily life change over time.
LimogesAges 20–60 - NCT06322017Recruiting
Early vein isolation for atrial fibrillation in older adults
This study compares doing vein isolation soon after diagnosis versus usual care in people 75+ with new or early atrial fibrillation. The goal is to see if early treatment prevents the condition from getting worse and improves quality of life.
Nantes, Loire AtlantiqueAges 75 years+ - NCT07038265Recruiting
Personalized cardiac rehab after a heart attack
This study tests a personalized cardiac rehabilitation program for people who have recently had a heart attack. The program is designed to be more patient-centered, helping you recover and lower your risk for future heart problems.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT07000084RecruitingPhase 3
Testing gemcitabine with BCG for returning bladder cancer
This trial tests whether adding a chemotherapy drug called gemcitabine to the usual BCG therapy can help prevent bladder cancer from coming back again. If you have had BCG before and your cancer returned, this study might offer a more effective treatment option.
Birmingham, AlabamaAges 18 years+ - NCT07466420Recruiting
Quercetin for fibrotic lung disease
This trial tests whether taking quercetin, a natural supplement, can help people with fibrotic interstitial lung diseases (a group of conditions that cause scarring in the lungs). If you have been diagnosed with idiopathic pulmonary fibrosis (IPF) or another fibrotic ILD and are on standard treatments, you may be able to join.
Heraklion, CreteAges 18 years+ - NCT05477537Recruiting
Physical activity program for teens and adults with anorexia
This trial studies an adapted, supervised physical activity program as part of treatment for people with anorexia nervosa. It may help improve physical function and overall well-being during specialized eating-disorder care.
LilleAges 12–40 - NCT06582784Recruiting
Using a phone app to help cancer survivors with depression
This study tests a mobile app to help cancer survivors who are feeling depressed. If you have a smartphone and are willing to use an app for mood support, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT05514730Recruiting
Treatment program for harmful sexual behaviors in children
This trial offers a treatment program for preteen children whose caregiver reports concerning sexual behaviors. It aims to help reduce these behaviors and improve child well-being, with participation guided by language and caregiver involvement.
Harrisburg, PennsylvaniaAges 4–12 - NCT07162493Recruiting
Feasibility trial of ATTACH program for families in Denmark
This trial tests a program called ATTACH to help parents and young children who are facing tough challenges, like mental health problems, substance abuse, or having a child in foster care. If you are a parent with a child under 5.7 years, speak English or Danish, and are getting support from a family treatment center, you may be able to join.
GribskovAges 18 years+ - NCT04267848RecruitingPhase 3
Testing immunotherapy with chemo after lung cancer surgery
This trial tests whether adding an immunotherapy medicine to standard chemotherapy after surgery can improve outcomes for some people with non-small cell lung cancer. It may help by boosting the immune system to reduce the chance the cancer comes back.
Anchorage, AlaskaAges 18 years+ - NCT05432804RecruitingPhase 1/Phase 2
Selinexor added to temozolomide for recurring brain glioblastoma
This trial studies whether adding selinexor to the standard chemotherapy temozolomide (with radiation) can better treat glioblastoma that has come back after prior treatment. If you meet specific tumor, health, and lab requirements, the goal is to slow tumor growth or improve symptoms.
Phoenix, ArizonaAges 18 years+ - NCT07539519Recruiting
Mental Health Treatment Toolkit for Autistic Teens
This study tests a new toolkit designed to help therapists better treat mental health conditions in autistic teenagers. Researchers want to improve care by training therapists to understand autism and how it affects mental health treatment.
Miami, FloridaAges 13 years+
Common questions
- Are there clinical trials studying Treatment as Usual?
- Yes. Clin2 currently lists 317 recruiting studies that include Treatment as Usual, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Treatment as Usual trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Treatment as Usual an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Treatment as Usual or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.