Clinical trials
ACL Reconstruction clinical trials
Below are recruiting acl reconstruction clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06875427RecruitingPhase 3
Nerve block vs no block for ACL surgery in kids
This trial tests whether a nerve block (a numbing shot) before ACL reconstruction helps young patients have less pain and better recovery compared to no block.
Hamilton, OntarioAges 10–18 - NCT06979804Recruiting
Comparing knee surgery outcomes with special fabric products
This study compares how well people do after anterior cruciate ligament (ACL) surgery, with or without also repairing the meniscus, using a special fabric product. It aims to see if the fabric helps improve recovery and outcomes for people with these common knee injuries.
Westmont, IllinoisAges 16–65 - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18 - NCT04183803Recruiting
Robot help to set the right position for ACL surgery
This study tests whether using a robot to help place the tunnel during ACL (knee ligament) reconstruction is better or more accurate than the usual approach. You may benefit if you need ACL surgery and your care team has robot experience.
AmiensAges 10 years+ - NCT07097077Recruiting
Brain changes after ACL surgery with special training
This study uses brain scans (fMRI) to see how a special type of movement training affects the brain after ACL surgery. If you've had an ACL repair and are active in sports, you may be eligible.
Bologna, BolognaAges 18–30 - NCT06991192Recruiting
ACL surgery rehab with exercise and mental support
This study tests a rehab program that combines physical exercises with psychological support to help young athletes recover from ACL surgery and return to sports safely.
Bloomington, MinnesotaAges 15–25 - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT07671729Recruiting
Comparing two tendon grafts for ACL surgery
This study compares two types of tendon grafts (from your kneecap tendon or from a tendon in your leg) for ACL reconstruction. The goal is to see which one works better for getting you back to normal activity.
Istanbul, BesiktasAges 18–50 - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT06798623RecruitingPhase 1
ACL repair with stem cells from your own knee fat
This trial tests whether adding stem cells from your knee fat pad to a standard ACL reconstruction helps you heal better. It is for Houston Methodist patients who can do physical therapy there and meet basic health requirements.
Houston, TexasAges 18 years+ - NCT07762989Recruiting
Ankle recovery after ACL surgery using a leg tendon graft
This study examines how well the ankle and lower leg recover after ACL reconstruction when the graft is taken from the peroneus longus tendon. By participating, you help doctors learn how this procedure affects ankle strength and function, which may improve future care.
Çankaya, AnkaraAges 18–55 - NCT06294314Recruiting
ACL surgery with bone marrow and internal brace for return to sports
This trial studies a new way to reconstruct a torn ACL using your own bone marrow cells and a special internal brace to help you return to sports. It's for young athletes who haven't had ACL surgery before.
Huntington, West VirginiaAges 14–26 - NCT06190223Recruiting
ACL repair using kneecap tendon with press-fit method
This study looks at a specific ACL reconstruction technique using a graft from your kneecap tendon that is fixed with a press-fit method. It aims to determine how well patients recover after at least one year.
AnkaraAges 18–55 - NCT04390035Recruiting
Blood-flow training after ACL surgery for teens
This trial looks at whether a special exercise method that changes blood flow during physical therapy (called BFRT) can improve recovery after ACL reconstruction in teens. It may help strength and rehab progress, but you would need to meet several surgery and safety requirements and attend many PT visits.
Atlanta, GeorgiaAges 12–18 - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06631690Recruiting
ACL surgery and ankle joint function study
This study looks at how ACL reconstruction knee surgery might affect the mechanics of your ankle joint. It aims to understand if the surgery changes how your ankle moves and works, which could help improve rehabilitation.
CairoAges 15–45 - NCT07671235Recruiting
Comparing graft options for repeat ACL surgery
This study compares two types of tissue grafts (your own or a donor's) used in a second ACL knee surgery to see which leads to better outcomes and fewer failures over at least two years.
Bologna, BolognaAges 18–50 - NCT06166381Recruiting
Antibiotics in ACL reconstruction: vein vs. vein plus soaked graft
This trial compares two methods for preventing infection during ACL reconstruction surgery. One group gets antibiotics through a vein, and the other group gets antibiotics through the vein plus a special antibiotic-soaked graft placed in the knee.
DuhokAges 20–45 - NCT04770233Recruiting
Comparing early surgery options for torn ACL
This study looks at the best way to treat a fresh ACL (an important knee ligament) tear by comparing an “early surgery” plan that starts within 12 weeks. It may help guide care and recovery for people who are able to do both the surgery and the follow-up rehabilitation.
Lørenskog, AkershusAges 16–50 - NCT07306221Recruiting
Balance training after ACL surgery using visual guides
This study tests if a special video-based balance training program helps people recover knee function better after ACL reconstruction surgery. It is designed for patients who had surgery within the past year using their own hamstring tendon.
BeijingAges 18–45 - NCT07043569Recruiting
Strength training with blood flow restriction after ACL surgery
This trial tests a special type of strength training that uses a blood pressure cuff to limit blood flow during exercises. It aims to help people recover muscle strength and improve knee function after ACL surgery.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18
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Common questions
- Are there clinical trials for acl reconstruction?
- Yes. Clin2 currently lists 93 recruiting acl reconstruction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acl reconstruction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acl reconstruction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.