Clinical trials
Acute Liver Failure clinical trials
Below are recruiting acute liver failure clinical trials, each written for real people, not researchers. We’re tracking 78 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07053488RecruitingPhase 1/Phase 2
Gene-edited liver transplant to lower rejection risk
This trial tests a liver transplant using a donor organ that has been gene-edited to reduce the risk of rejection. It may help people who need a liver transplant and are not a perfect tissue match with their donor.
Beijing, ChangpingAges 16–85 - NCT07275554Recruiting
Gene patterns and risk prediction in hepatitis B liver failure
This study looks at how gene changes (methylation) in people with hepatitis B-related liver failure may predict how well they will do. It aims to create a risk score to guide treatment.
Jinan, ShandongAges 18 years+ - NCT07329036Recruiting
Liver support therapy for acute liver failure
This trial tests two different blood-filtering treatments for people with severe liver failure who are waiting for or unable to receive a liver transplant. It aims to see how these treatments affect blood clotting, inflammation, and organ function.
PragueAges 18–75 - NCT06987604Enrolling by invitation
Dialysis intensity for high ammonia in liver failure
This trial tests if a higher intensity of continuous dialysis (CRRT) better lowers ammonia levels in patients with liver failure. It aims to find the best approach to reduce brain complications from high ammonia.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06893042Enrolling by invitation
Study of acute liver failure in children
This trial looks at children with sudden severe liver injury. It tests treatments for acute liver failure to understand how to help them recover.
Guangzhou, GuangdongAges 1 minute–18 years - NCT06993220Recruiting
Reducing fluid buildup in heart failure patients at discharge
This trial is for people hospitalized with heart failure and signs of fluid overload, such as swelling or fluid in the lungs. It aims to check if patients still have extra fluid when they go home, which may help improve their recovery.
Sant Joan Despí, BarcelonaAges 18 years+ - NCT07438288Recruiting
Predicting Liver Failure in People with Cirrhosis
This study follows people with liver cirrhosis—a condition where the liver is scarred—to see who gets worse or develops sudden liver failure. The goal is to find early warning signs so doctors can help prevent serious problems.
SingaporeAges 18 years+ - NCT05392764RecruitingPhase 3
SGLT2 medicine for high-risk people after sudden worsening heart failure
This Phase 3 trial tests whether starting an SGLT2 inhibitor early in the hospital can improve outcomes for people at high risk after acute (sudden) heart failure. If you qualify, you would be randomized to receive the study medicine or standard care, started within 12 hours of admission.
Anjo, Aichi-kenAges 20 years+ - NCT07345156Recruiting
Congestion and lactate at discharge in heart failure
This trial studies a simple test (lung ultrasound and a blood test for lactate) done right before you leave the hospital for heart failure. It aims to see if these tests help doctors know how well you are recovering and if you might need extra care after discharge.
Monastir, Monastir GovernorateAges 18 years+ - NCT05540834RecruitingPhase 2
Testing blood-clot guidance for ICU patients with severe lung failure
This Phase 2 trial tests whether using a blood test that shows clotting strength and “clot breakdown time” can help guide treatment for people in the ICU with acute respiratory failure from infection. If you qualify, the team will use these blood results to decide on clot-related therapy and compare outcomes to standard care.
Liverpool, New South WalesAges 18–75 - NCT06653725RecruitingPhase 2
Ketone supplement study for hospitalized heart failure patients
This trial tests if a ketone supplement can help people hospitalized for acute heart failure. The supplement is given orally and aims to support the heart and energy levels during recovery.
AalborgAges 18 years+ - NCT07312864RecruitingPhase 1/Phase 2
New bioartificial liver for liver failure and small-for-size syndrome
This study tests a new bioartificial liver made from special cells to support people with severe liver problems, including liver failure or when the liver is too small after surgery. It aims to see if it is safe and can help the liver recover.
BeijingAges Any age - NCT02638142Recruiting
Testing IV diuretic treatment for sudden worsening heart failure
This trial studies how an IV (into-the-vein) “water pill” (furosemide/loop diuretic) works in people whose heart failure has suddenly gotten worse. It may help doctors find the best way to reduce fluid-related symptoms like breathing trouble and swelling.
Chioggia, VeneziaAges 18 years+ - NCT06938217Enrolling by invitation
Low-flow ECMO for adults with severe breathing failure
This study tests whether a gentler, low-blood-flow version of ECMO (a machine that helps oxygenate blood outside the body) is safe and effective for adults with very severe breathing failure. It is for patients who are already on a breathing machine and have very low oxygen levels despite that support.
San Antonio, TexasAges 18–65 - NCT04332692Recruiting
Check if a lung ultrasound helps evaluate discharge after heart failure
This study looks at whether doing lung ultrasounds can better assess people right before they leave the hospital after an acute heart failure flare. It may help doctors decide when someone is ready for discharge and tailor care to reduce risk after leaving.
Vandœuvre-lès-NancyAges 18 years+ - NCT06871111RecruitingPhase 1
Bacteria treatment study for liver disease patients
This trial tests whether giving a mixture of helpful bacteria can improve gut health in people hospitalized with serious liver problems. It aims to see if restoring these bacteria can help with recovery.
Chicago, IllinoisAges 18 years+ - NCT06166654RecruitingPhase 4
Better water pill therapy for acute heart failure
This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
Hvidovre, Capital Region of DenmarkAges 18 years+ - NCT05919680RecruitingPhase 2
NST-6179 for liver disease from intestinal failure in adults
This Phase 2 study tests NST-6179 in people who have intestinal failure–associated liver disease (IFALD). It aims to improve liver function and overall outcomes for people whose liver inflammation and lab tests have been abnormal for at least 6 months.
Scottsdale, ArizonaAges 16 years+ - NCT06781502Recruiting
Liver Disease and Transplant Study
This study is creating a database of people with severe liver problems or who have had a liver transplant. The goal is to learn more about these conditions and improve care.
Bologna, BolognaAges 18 years+ - NCT07631221Recruiting
Protein Amount in Nutrition for Critically Ill Kidney Patients
This study tests whether different amounts of protein in tube feeding or IV nutrition affect kidney recovery in patients admitted to the intensive care unit (ICU) with kidney injury. The goal is to find the best protein level to help kidneys heal while patients are critically ill.
Buenos Aires, Buenos AiresAges 18 years+ - NCT03920618Recruiting
Testing three HBV medicines for severe liver flare (ACLF)
This study compares three hepatitis B (HBV) medicines to see which treatment helps people with a severe liver flare. You may be eligible if you have confirmed HBV and lab results showing significant liver stress.
Guangzhou, GuangdongAges 12–65 - NCT06562803Recruiting
Cleaning the blood for liver failure with sepsis
This trial tests if a special blood-filtering method combined with plasma exchange can help people with severe liver failure and sepsis. It aims to reduce inflammation and improve survival.
Guangzhou, GuangdongAges 18–70 - NCT06948565Recruiting
Cirrhosis patients in the ICU: a 10-year review
This study looks back at medical records of people with cirrhosis who were treated in an intensive care unit (ICU) over the last 10 years. Researchers want to understand what factors affect their recovery and outcomes.
BesançonAges Any age - NCT07198854Recruiting
Stem cell treatment for liver failure in hepatitis B patients
This trial looks at how well stem cell (MSC) treatment works for people with severe liver failure caused by hepatitis B. It checks what factors affect the success of the treatment.
Guangzhou, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for acute liver failure?
- Yes. Clin2 currently lists 78 recruiting acute liver failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute liver failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute liver failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.