Clinical trials
Advanced Chronic Liver Disease clinical trials
Below are recruiting advanced chronic liver disease clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06181409Recruiting
New scans to detect liver disease complications
This study uses two types of scans (MRI and ultrasound) to check for high pressure in the veins of your liver. It may help doctors find problems earlier without invasive tests.
Montreal, QuebecAges 18 years+ - NCT04524871RecruitingPhase 1/Phase 2
Immunotherapy combinations for advanced liver cancer
This Phase 1/2 study tests new combinations of immune system medicines in people with advanced liver cancer that cannot be cured by surgery. It looks for safer treatment and signs that the medicines can shrink or control the cancer.
Costa Mesa, CaliforniaAges 18 years+ - NCT07042308Recruiting
Study of advanced chronic liver disease over time
This study follows people with advanced chronic liver disease to understand how their condition changes over time. If you have cirrhosis or high liver stiffness, you may be able to join to help researchers track the disease and learn more about it.
Hong KongAges 18 years+ - NCT07317193Recruiting
Genetic causes of adult bile duct disease
This study looks for new genes that might cause abnormal liver test results or specific bile duct diseases in adults, when standard testing hasn't found a clear cause. It also uses healthy blood donors as a comparison group.
Milan, MilanoAges 18–65 - NCT07544524Recruiting
Plant-Based Diet for Kidney Disease in Asian Adults
This study tests whether eating mostly plants (with some animal products) can safely help people with moderate kidney disease. Researchers will compare this diet to a standard kidney-friendly diet and see how it affects kidney function and overall health.
SingaporeAges 21–79 - NCT06613698RecruitingPhase 2
Testing an investigational drug for alcohol-related liver disease
This trial tests whether a new drug, GSK4532990, is safe and effective compared to a placebo in adults aged 18 to 70 with liver disease caused by alcohol use. The study aims to see if the drug can help treat advanced chronic liver disease.
Chandler, ArizonaAges 18–70 - NCT05548452RecruitingPhase 1/Phase 2
Microbiota transplant for advanced liver disease from alcohol
This trial tests whether giving a healthy mix of gut bacteria (an intestinal microbiota transplant) can improve outcomes in people with advanced liver disease caused by ongoing alcohol use. It may help rebalance the gut and support liver health, but participation depends on strict safety and diagnosis criteria.
Richmond, VirginiaAges 18 years+ - NCT05205954Recruiting
Home hospital care for adults with advanced liver disease
This pilot study tests whether a “home hospital” program can safely care for people with advanced liver disease after they are admitted to the hospital. It may reduce time in the hospital while still treating serious complications like fluid buildup, breathing fluid, or confusion from liver disease.
Boston, MassachusettsAges 18 years+ - NCT05475015Recruiting
3D MRI scan to assess liver scarring and pressure
This study tests whether a special 3D MRI scan (3D-MRE) can measure liver scarring and the high pressure in the liver called portal hypertension. It may help your team use imaging to understand how severe your liver disease is, especially when a pressure test (HVPG) is being considered.
Shenyang, LiaoningAges 18–75 - NCT05733832Recruiting
Transitional care after hospital discharge for serious liver disease
This trial tests an extra support program after you leave the hospital to help people with advanced liver disease avoid complications and stay on track. It may help by providing structured follow-up soon after discharge.
Chicago, IllinoisAges 18 years+ - NCT05998330Recruiting
Palliative care support for advanced liver disease patients
This study tests whether adding palliative care (extra support for symptoms and planning) during a hospital stay helps people with advanced liver disease and their caregivers feel better and plan ahead.
Boston, MassachusettsAges 18 years+ - NCT06068491Recruiting
Veteran-centered care for advanced liver disease
This study tests a new way of caring for veterans with advanced liver disease. It aims to help you manage your condition better and improve your quality of life.
Little Rock, ArkansasAges 18–80 - NCT06266260Recruiting
Measuring liver pressure with ultrasound for advanced liver disease
This trial uses a minimally invasive ultrasound technique to directly measure blood pressure in the liver's main vein. It may help doctors decide if patients with severe scarred livers need medication to prevent variceal bleeding.
RomaAges 18–99 - NCT06322056Recruiting
Lower blood pressure and cholesterol targets for advanced kidney disease
This trial tests whether keeping blood pressure and cholesterol at lower-than-usual levels can help slow the decline of kidney function in people with advanced chronic kidney disease. If you have moderately to severely reduced kidney function and meet certain blood pressure and cholesterol criteria, you may be able to join.
SeoulAges 19 years+ - NCT06434753RecruitingPhase 3
Zinc supplements for stable advanced liver disease
This trial tests whether taking zinc supplements can improve the outlook for people with a certain type of advanced liver disease that is still stable (no major complications). If you have compensated advanced chronic liver disease and meet the criteria, you might be able to join.
BarcelonaAges 18–80 - NCT06449339RecruitingPhase 4
Beta-blocker study for early-stage liver scarring
This study tests a medicine called carvedilol (a non-selective beta-blocker) to see if it can prevent complications in people with advanced chronic liver disease who are at high risk but haven't had serious problems like bleeding yet.
Hong KongAges 18 years+ - NCT06523608Recruiting
Predicting liver problems in advanced chronic liver disease
This study looks at people with advanced chronic liver disease to find ways to predict when they might get worse or develop liver cancer. Researchers hope to use this information to prevent complications and improve care.
Münster, North Rhine-WestphaliaAges 18 years+ - NCT07053488RecruitingPhase 1/Phase 2
Gene-edited liver transplant to lower rejection risk
This trial tests a liver transplant using a donor organ that has been gene-edited to reduce the risk of rejection. It may help people who need a liver transplant and are not a perfect tissue match with their donor.
Beijing, ChangpingAges 16–85 - NCT07193927RecruitingPhase 2
Testing a probiotic mix for fatty liver disease (MASLD)
This trial tests whether a probiotic mixture can improve liver health in people with moderate fatty liver disease (MASLD). It looks at how the probiotic affects liver fat, inflammation, and metabolism.
Girona, GironaAges 18–75 - NCT05699018Recruiting
Screening people with liver scarring in primary care
This study tests how well primary care doctors can screen for advanced liver scarring in people with fatty liver from non-alcohol causes or from alcohol use. It may help find liver problems earlier so you can get the right follow-up.
AngersAges 40–80 - NCT07446491RecruitingPhase 1/Phase 2
PN20 for low platelets in liver disease patients needing a procedure
This study tests a new medicine called PN20 to safely raise platelet counts in people with chronic liver disease who need a minor procedure (like a biopsy). It's for patients whose platelet count is below 50 and whose liver disease is not too severe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07610837RecruitingPhase 2
Testing AZD2389 for fatty liver disease with scarring
This study tests whether a new drug called AZD2389 is safe and well-tolerated in adults with steatotic liver disease (fatty liver) that has progressed to advanced scarring. The trial aims to see if this drug might help slow or improve liver damage in people with this condition.
Chandler, ArizonaAges 18 years+ - NCT06838468Enrolling by invitation
Study on liver health in alcohol detox patients
This study is looking at liver health in people staying in a detox unit for alcohol use disorder. Researchers want to see how common liver problems are in this group. Participating involves extra tests like blood work, an ultrasound, and a special liver scan (FibroScan).
Sabadell, BarcelonaAges 18–75 - NCT05001009Enrolling by invitation
Goals of care conversation support for certain serious illnesses
This study helps primary care clinicians and their patients have structured “goals of care” conversations (about what matters most and care preferences). It may help you get clearer, earlier planning—especially if you have a serious illness and higher risk of hospitalization or death.
Palo Alto, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for advanced chronic liver disease?
- Yes. Clin2 currently lists 94 recruiting advanced chronic liver disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced chronic liver disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced chronic liver disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.