Clinical trials
Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 5,553 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04957511Recruiting
Testing gut bacteria in gynecologic cancer patients on immunotherapy
This study looks at how gut bacteria may relate to how well immunotherapy works in people with advanced or returning gynecologic cancer. You may be asked to give stool samples several times so researchers can measure changes in your gut microbiome.
Orlando, FloridaAges 18 years+ - NCT05911230Recruiting
MRI test to tell tumor return from temporary treatment effects
This study uses an advanced MRI scan to help doctors tell the difference between true tumor regrowth and “pseudoprogression,” which is a temporary treatment-related change that can look like progression. If it works, it may guide the safest next steps, including whether surgery is helpful.
BaselAges 18 years+ - NCT07445022RecruitingPhase 4
Study of tunlametinib for advanced melanoma with NRAS mutation
This trial tests a new oral targeted therapy (Tunlametinib) for people with advanced melanoma that has a specific gene change called NRAS. It's for those who have already tried immunotherapy and need another option.
ShanghaiAges 18 years+ - NCT07446634Recruiting
Jaw advancement surgery for sleep apnea
This study tests jaw advancement surgery for people with obstructive sleep apnea who haven't been helped by CPAP or mouthpieces. It looks at whether moving the jaw forward can improve breathing during sleep.
Falun, Dalarna CountyAges 18–70 - NCT07448922RecruitingPhase 2
Study of SKB518 for advanced gynecologic cancers
This trial tests a new drug called SKB518, either alone or with other treatments, for people with advanced gynecologic cancers (ovarian, cervical, or endometrial) who have already had some treatment. It aims to see if the drug helps shrink or control the cancer.
ChongqingAges 18–75 - NCT07448116RecruitingPhase 1/Phase 2
Testing MCLA-129 plus ensartinib for advanced solid tumors
This trial tests a new two-drug combination (MCLA-129 and ensartinib) for people with advanced solid tumors that have a specific genetic change called MET amplification or overexpression. The goal is to see if this combo can shrink tumors or stop them from growing when other treatments have stopped working.
Beijing, Beijing MunicipalityAges 18–75 - NCT07450976RecruitingPhase 2
Targeted drug for advanced biliary tract cancer after standard treatment
This trial tests a new targeted drug (SHR-A1904) in people with advanced biliary tract cancer whose tumors have a specific protein (Claudin18.2) and who have already tried at least one standard treatment. The goal is to see if this drug can shrink the cancer or slow its growth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07441226RecruitingPhase 2
Stem cells for advanced COPD treatment
This trial tests whether adding umbilical cord stem cells to standard triple therapy can help people with Group E COPD. It aims to see if this approach improves lung function and quality of life.
Jakarta, Jakarta Special Capital RegionAges 40–75 - NCT07442669Recruiting
Lung ultrasound for surfactant decision in premature babies
This trial uses a lung ultrasound score, a type of ultrasound, to decide when to give surfactant (a medicine that helps lungs work) to premature babies born between 27 and 35 weeks of pregnancy. It aims to reduce the need for more breathing support and avoid side effects.
Hackensack, New JerseyAges 6 months–8 months - NCT07444216Recruiting
A study on hope in teens and young adults with advanced cancer
This study explores hope in patients aged 12-25 with pediatric cancer that has returned, not responded to treatment, or has no cure. Participants take photos and share their stories to help doctors and families understand what hope means during early-phase clinical trials (phase 1 or 2).
Memphis, TennesseeAges 12 years+ - NCT06718946RecruitingEarly Phase 1
IV IDOV-SAFE for advanced solid tumors: safety and effect study
This trial tests a new drug called IDOV-SAFE given through a vein. It is for people with advanced solid tumors that have not responded to standard treatments. The study aims to see if the drug is safe and if it can help shrink tumors.
ShanghaiAges 18–75 - NCT07428577Recruiting
Tracking care for advanced HIV patients after hospital stay
This trial looks at whether staying in contact with patients after they leave the hospital helps them get better follow-up care. If you have advanced HIV and are in the hospital for a related illness, you may be able to join.
Johannesburg, GautengAges 18 years+ - NCT06801470RecruitingPhase 1
Testing the safety of CD-001 in advanced solid tumors
This early-phase trial tests a new drug (CD-001) for people with advanced solid tumors. It will check if the drug is safe, how the body handles it, and if it helps shrink tumors.
TianjinAges 18 years+ - NCT05532059RecruitingPhase 2
Test lenvatinib, tislelizumab, and chemotherapy for bile duct cancer
This Phase 2 trial tests a combination of lenvatinib, an immunotherapy drug (tislelizumab), and chemotherapy (gemcitabine plus cisplatin) for advanced bile duct cancer that cannot be removed with surgery. It aims to see whether this treatment can shrink tumors and improve outcomes, especially for people who have not yet had immunotherapy.
Hangzhou, ZhejiangAges 18–85 - NCT05823311RecruitingPhase 3
Test lenvatinib and immunotherapy plus chemo for bile duct cancer
This Phase 3 study tests whether a combination of lenvatinib, an immunotherapy medicine (tislelizumab), and chemotherapy (gemcitabine plus cisplatin) works better for advanced bile duct cancer that cannot be fully removed by surgery. It may help people live longer or control the cancer for longer.
Hangzhou, ZhejiangAges 18–75 - NCT06464055RecruitingPhase 1/Phase 2
A study of GQ1010 for advanced solid tumors
This trial tests a new drug called GQ1010 for people with advanced solid tumors that have stopped responding to standard treatments. The drug targets a protein called Trop-2 on cancer cells to try to shrink tumors or slow their growth.
BeijingAges 18 years+ - NCT07422610RecruitingPhase 1
Study of Pelabresib for advanced cancer with liver issues
This trial tests how the drug pelabresib works in people with advanced cancer who also have mild to severe liver problems. It aims to understand safety and how the drug moves through the body.
BordeauxAges 18–75 - NCT06055387Recruiting
Frailty care for older stomach cancer patients after surgery
This study tests a frailty assessment and intervention program for people aged 65+ with stage II or III stomach cancer who will have surgery and chemotherapy afterward. It aims to improve recovery and quality of life.
Taoyuan, TaiwanAges 65 years+ - NCT07414836RecruitingPhase 1
First test of new drug BG-C0979 for advanced solid tumors
This study tests a new drug called BG-C0979 for advanced solid tumors that have not responded to standard treatments. It may be given alone or with other therapies to see if it can shrink tumors or slow cancer growth.
Boston, MassachusettsAges 18 years+ - NCT07410117RecruitingPhase 3
Preventing blood clots in advanced solid tumor cancer
This trial tests a new drug called REGN7508 to see if it can prevent dangerous blood clots in people with advanced or metastatic solid tumors. People with a higher risk of clots (based on a simple score or tumor genetics) may qualify.
Hialeah, FloridaAges 18 years+ - NCT07408258RecruitingPhase 1
Safety and dosing study of ONC-783 for advanced solid tumors
This trial tests an experimental drug called ONC-783 for people with advanced pancreatic, ovarian, colorectal, or breast cancer. The goal is to see if the drug is safe, how it works in the body, and whether it can help shrink tumors.
New York, New YorkAges 18 years+ - NCT07413328RecruitingPhase 1
HWS116 for advanced solid tumors
This trial tests an experimental drug, HWS116, for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug can help shrink tumors or slow their growth.
Guangzhou, GuangdongAges 18 years+ - NCT07407439Recruiting
Real-world study of CDK4/6 inhibitors in advanced breast cancer
This study looks at how well CDK4/6 inhibitors (a type of targeted therapy) work in real-world patients with HR+/HER2- advanced breast cancer. By collecting medical data from people treated at this hospital, doctors hope to learn more about the effectiveness and safety of these drugs in everyday practice.
TianjinAges 18 years+ - NCT07409805RecruitingPhase 1
Vaccine trial for advanced colorectal cancer with liver spread
This trial tests a new vaccine (YMN-136) for people with colorectal cancer that has spread to the liver and hasn't responded to at least three prior treatments. The goal is to see if the vaccine can help control the cancer.
Chengdu, SichuanAges 18–75
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Common questions
- Are there clinical trials for advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 5,553 recruiting advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Locally Advanced Non-Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.