Clinical trials
Anterior Cruciate Ligament Rupture clinical trials
Below are recruiting anterior cruciate ligament rupture clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06974526RecruitingPhase 2
Study of a dissolvable implant for recovery after ACL surgery
This study tests whether a dissolvable implant that releases a medication called oxandrolone can improve recovery after ACL surgery. Oxandrolone may help strengthen the new ligament and speed up healing.
Fortaleza, CearáAges 18–60 - NCT07322497Recruiting
Phone app vs. supervised exercise before ACL surgery
This study compares two ways to exercise before ACL surgery: using a video app on your phone versus doing exercises with a physical therapist. The goal is to see which approach helps you recover better.
Istanbul, KartalAges 18–45 - NCT07009392Recruiting
Bacteria in the knee during ACL surgery
This study looks for bacteria inside the knee joint during ACL (anterior cruciate ligament) surgery, either for the first time or after a previous surgery. The goal is to learn more about the knee's natural bacteria, which might help improve recovery and prevent infections.
LyonAges 18 years+ - NCT03365908Enrolling by invitation
Pain Management After ACL Reconstruction Surgery
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
Sacramento, CaliforniaAges 18–45 - NCT07318272Recruiting
ACL surgery repair vs. reconstruction recovery study
This study compares how well people recover after two different types of ACL surgery: reconstruction (using a graft) and primary repair (stitching the torn ligament). It will help doctors understand which approach leads to better knee function long-term. Participants must be between 18 and 40, had their ACL surgery at Gazi University, and be at least one year past surgery.
Ankara, ÇankayaAges 18–40 - NCT06178497Recruiting
5-Year Check-In After ACL Repair
This study checks on people who had ACL (anterior cruciate ligament) repair surgery 5 years ago to see how well their knee is doing. It looks at a specific type of ACL tear (a 'proximal' tear) and helps doctors understand long-term results.
Lille, Choisir Une RégionAges 18 years+ - NCT06259968Recruiting
Electrical stimulation after ACL surgery recovery trial
This trial tests if adding electrical stimulation to standard physical therapy helps people recover strength and movement after ACL reconstruction surgery. It compares two rehab programs starting within days after surgery.
Veranópolis, Rio Grande do SulAges 18–40 - NCT05395767Recruiting
Living-donor tendon graft for ACL repair in teens
This study tests whether an ACL reconstruction using a tendon from a living donor works well and is safe in children and teens. It may help families compare this approach while closely tracking knee function after surgery.
Pembury, KentAges 8–17 - NCT06099600Recruiting
ACL reconstruction study with follow-up via app
This trial is for people getting ACL (anterior cruciate ligament) surgery. It tests if tracking your recovery through questionnaires on a phone or tablet helps improve outcomes.
LyonAges 18 years+ - NCT06905691Recruiting
Eccentric training after ACL reconstruction
This study tests if a specific exercise (eccentric training) helps people recover better after ACL surgery. You may join if you are between 18 and 40 and are scheduled for this surgery.
Veranópolis, Rio Grande do SulAges 18–40 - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18 - NCT04295148Recruiting
Compare brace and rehab for ACL reconstruction
This study compares two ways of rehabilitating the knee after ACL rupture repair. It’s meant to see which approach helps people return to their prior sport more safely and effectively.
Stockholm, Stockholm CountyAges 16–40 - NCT04390035Recruiting
Blood-flow training after ACL surgery for teens
This trial looks at whether a special exercise method that changes blood flow during physical therapy (called BFRT) can improve recovery after ACL reconstruction in teens. It may help strength and rehab progress, but you would need to meet several surgery and safety requirements and attend many PT visits.
Atlanta, GeorgiaAges 12–18 - NCT04408885Recruiting
Rehab program for a torn ACL ligament
This study looks at a rehabilitation-focused treatment plan after an ACL (an important knee ligament) tear. It may help you by testing the best rehab approach for improving knee function and stability.
Aarhus NAges 18–50 - NCT04781920Recruiting
Follow-up after ACL ligament surgery
This study is checking how people are doing after anterior cruciate ligament (ACL) reconstruction (a surgery to repair a knee ligament). It may help researchers understand recovery and long-term outcomes after ACL surgery.
Saint-EtienneAges 18 years+ - NCT05174611RecruitingPhase 2
Vitamin D to strengthen the thigh after ACL surgery
This Phase 2 study tests whether taking vitamin D can improve thigh (quadriceps) muscle strength after ACL reconstruction. It targets people with low vitamin D levels that persist after surgery and weaker thigh strength on the injured side.
Hong KongAges 18–40 - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25 - NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT05501210Recruiting
Knee vibration therapy for ongoing front-of-knee pain after ACL surgery
This trial studies whether a vibrating device on the front of the knee can reduce persistent pain after ACL reconstruction. It may help people whose pain is focused in one knee and isn’t caused by arthritis or other knee problems.
Hong KongAges 18–60 - NCT05747079Recruiting
Early versus delayed surgery after a new ACL tear
This study compares immediate surgery versus waiting a short time for people with a new ACL injury. It aims to see which timing leads to better recovery and knee function.
LeuvenAges 16 years+ - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT06190223Recruiting
ACL repair using kneecap tendon with press-fit method
This study looks at a specific ACL reconstruction technique using a graft from your kneecap tendon that is fixed with a press-fit method. It aims to determine how well patients recover after at least one year.
AnkaraAges 18–55 - NCT06194682Recruiting
ACL reconstruction follow-up study
This study follows people who have had or will have ACL reconstruction surgery at this hospital. It helps doctors learn more about how patients recover after ACL surgery over the long term.
MilanAges 18–65
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Common questions
- Are there clinical trials for anterior cruciate ligament rupture?
- Yes. Clin2 currently lists 67 recruiting anterior cruciate ligament rupture studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament rupture trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament rupture trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.