Clinical trials
Anterior Cruciate Ligament Rupture clinical trials
Below are recruiting anterior cruciate ligament rupture clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06235736Recruiting
Do ACL tears cause weakness in the soleus muscle?
This study looks at whether people with ACL tears have weakness in a specific calf muscle called the soleus. If you have an ACL tear, you will do strength tests to compare with healthy individuals.
LiverpoolAges 18–55 - NCT06294314Recruiting
ACL surgery with bone marrow and internal brace for return to sports
This trial studies a new way to reconstruct a torn ACL using your own bone marrow cells and a special internal brace to help you return to sports. It's for young athletes who haven't had ACL surgery before.
Huntington, West VirginiaAges 14–26 - NCT06357091Recruiting
ACL repair with Shark Screw or standard screw
This trial compares two types of screws used to hold a new ACL in place: a Shark Screw and a standard biocomposite screw. It may help if you have a torn ACL that needs surgery.
Schwaz, TyrolAges 18 years+ - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT06379308Recruiting
ACL revision surgery study in France
This study looks at people who need a second ACL surgery (revision). It helps doctors learn more about these procedures to improve care.
Saint-EtienneAges 18 years+ - NCT06430775Recruiting
Long-term ACL recovery after surgery
This study is looking at how well the ACL heals after surgery in the long term. It helps researchers understand recovery patterns, so you may get a closer look at your knee's healing process.
Roeselare, West-VlaanderenAges 18–40 - NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT06511232RecruitingPhase 4
Morphine in bone for ACL surgery pain
This trial tests if giving morphine directly into the bone during ACL reconstruction can reduce pain after surgery. It may help patients who are having a specific type of ACL repair using their own patellar tendon.
Houston, TexasAges 18–40 - NCT06608394Recruiting
Exercise habits and knee recovery after ACL surgery
This study looks at how your exercise habits before surgery might affect your knee function and the chance of re-injury after anterior cruciate ligament (ACL) reconstruction. It aims to help doctors give better advice on post-surgery rehabilitation.
Beijing, Beijing MunicipalityAges 18–45 - NCT06664047Recruiting
Two ACL repair methods compared for better recovery
This trial compares two different ways to repair a torn ACL (with an extra stabilizing procedure) to see which works better. It is for people with an isolated ACL tear who haven't had knee surgery before and are between 18 and 50 years old.
AnkaraAges 18–50 - NCT06727344Recruiting
ACL recovery with blood flow restriction therapy
This study tests whether adding blood flow restriction (gentle pressure applied to the upper leg during exercise) to standard treatment can help heal a completely torn ACL. If you have a full ACL tear and can speak Greek, you may be able to join.
NicosiaAges 18–40 - NCT06858930Recruiting
Navigation system for ACL reconstruction
This trial tests a special computer navigation system to help surgeons place the new ACL graft more precisely during knee reconstruction. If you have a torn ACL and are between 18 and 80, this study might help improve your surgery outcomes.
Beijing, Beijing MunicipalityAges 18–80 - NCT06955026Recruiting
Hockey slideboard and blood flow restriction for ACL rehab
This trial tests if using a hockey slideboard with blood flow restriction (a special band that limits blood flow during exercise) helps recovery after ACL surgery. It may improve muscle strength and function faster.
Odorheiu Secuiesc, RomaniaAges 18–45 - NCT06956339Recruiting
Bracing vs Surgery for First-Time ACL Tear
This trial compares a new bracing treatment (Cross Bracing Protocol) versus standard surgery for people who have torn their ACL for the first time. It aims to see which approach leads to better recovery and fewer complications.
Melbourne, VictoriaAges 16–40 - NCT06974526RecruitingPhase 2
Hormone implant for ACL surgery recovery
This trial tests a small implant that slowly releases the hormone oxandrolone to help you recover strength and function faster after ACL reconstruction surgery. It is for people who are already active and have no major health problems that could interfere with the medicine.
Fortaleza, CearáAges 18–60 - NCT06979804Recruiting
Comparing knee surgery outcomes with special fabric products
This study compares how well people do after anterior cruciate ligament (ACL) surgery, with or without also repairing the meniscus, using a special fabric product. It aims to see if the fabric helps improve recovery and outcomes for people with these common knee injuries.
Westmont, IllinoisAges 16–65 - NCT07023653Recruiting
ACL repair: comparing all-inside vs. standard tunnel surgery
This study compares two ways of repairing a torn ACL: a newer 'all-inside' method versus a standard tunnel method. It is designed for adults with a simple ACL tear, not for those with multiple ligament injuries, severe cartilage damage, or active infection.
DepokAges 18–65 - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT07043569Recruiting
Strength training with blood flow restriction after ACL surgery
This trial tests a special type of strength training that uses a blood pressure cuff to limit blood flow during exercises. It aims to help people recover muscle strength and improve knee function after ACL surgery.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07333092Recruiting
Balance exercises after ACL surgery
This trial tests whether special balance and movement exercises (proprioceptive exercises) help people recover better after ACL knee surgery. You would start these exercises during the second week of your rehab program.
SanliurfaAges 20–40 - NCT02771548Recruiting
Strength and movement study after ACL knee surgery
This study looks at how your knee moves during daily-style tasks and how strong your muscles are after ACL surgery. It may help researchers understand recovery and improvement after reconstruction.
Dublin, LeinsterAges 13–45 - NCT02511158Recruiting
Knee ligament surgery study after ACL reconstruction
This study follows people who have a knee ligament tear and undergo surgery to rebuild the ligament. It may help doctors better understand recovery and outcomes after different surgical techniques.
ParisAges 7 years+ - NCT07423767Recruiting
Counseling before ACL surgery to reduce fear and improve recovery
This study tests whether a short counseling program before ACL surgery can help reduce fear of movement and improve recovery. If you are preparing for your first ACL reconstruction, this program may help you feel more confident and get back to activities sooner.
Beijing, None SelectedAges 18–45 - NCT07671729Recruiting
Comparing two tendon grafts for ACL surgery
This study compares two types of tendon grafts (from your kneecap tendon or from a tendon in your leg) for ACL reconstruction. The goal is to see which one works better for getting you back to normal activity.
Istanbul, BesiktasAges 18–50
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Common questions
- Are there clinical trials for anterior cruciate ligament rupture?
- Yes. Clin2 currently lists 67 recruiting anterior cruciate ligament rupture studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament rupture trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament rupture trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.