Clinical trials
Anterior Cruciate Ligament Rupture clinical trials
Below are recruiting anterior cruciate ligament rupture clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06979804Recruiting
Comparing knee surgery outcomes with special fabric products
This study compares how well people do after anterior cruciate ligament (ACL) surgery, with or without also repairing the meniscus, using a special fabric product. It aims to see if the fabric helps improve recovery and outcomes for people with these common knee injuries.
Westmont, IllinoisAges 16–65 - NCT07043569Recruiting
Strength training with blood flow restriction after ACL surgery
This trial tests a special type of strength training that uses a blood pressure cuff to limit blood flow during exercises. It aims to help people recover muscle strength and improve knee function after ACL surgery.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT07023653Recruiting
ACL repair: comparing all-inside vs. standard tunnel surgery
This study compares two ways of repairing a torn ACL: a newer 'all-inside' method versus a standard tunnel method. It is designed for adults with a simple ACL tear, not for those with multiple ligament injuries, severe cartilage damage, or active infection.
DepokAges 18–65 - NCT07009392Recruiting
Bacteria in the knee during ACL surgery
This study looks for bacteria inside the knee joint during ACL (anterior cruciate ligament) surgery, either for the first time or after a previous surgery. The goal is to learn more about the knee's natural bacteria, which might help improve recovery and prevent infections.
LyonAges 18 years+ - NCT06974526RecruitingPhase 2
Study of a dissolvable implant for recovery after ACL surgery
This study tests whether a dissolvable implant that releases a medication called oxandrolone can improve recovery after ACL surgery. Oxandrolone may help strengthen the new ligament and speed up healing.
Fortaleza, CearáAges 18–60 - NCT06961292Enrolling by invitation
Knee ligament surgery study for ACL tears with extra rotation
This study compares two surgery techniques for ACL tears where the knee also twists too much inward. It aims to find which method leads to better long-term knee stability.
BeijingAges 18 years+ - NCT06956339Recruiting
Bracing vs Surgery for First-Time ACL Tear
This trial compares a new bracing treatment (Cross Bracing Protocol) versus standard surgery for people who have torn their ACL for the first time. It aims to see which approach leads to better recovery and fewer complications.
Melbourne, VictoriaAges 16–40 - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT06511232RecruitingPhase 4
Morphine in bone for ACL surgery pain
This trial tests if giving morphine directly into the bone during ACL reconstruction can reduce pain after surgery. It may help patients who are having a specific type of ACL repair using their own patellar tendon.
Houston, TexasAges 18–40 - NCT04295148Recruiting
Compare brace and rehab for ACL reconstruction
This study compares two ways of rehabilitating the knee after ACL rupture repair. It’s meant to see which approach helps people return to their prior sport more safely and effectively.
Stockholm, Stockholm CountyAges 16–40 - NCT06357091Recruiting
ACL repair with Shark Screw or standard screw
This trial compares two types of screws used to hold a new ACL in place: a Shark Screw and a standard biocomposite screw. It may help if you have a torn ACL that needs surgery.
Schwaz, TyrolAges 18 years+ - NCT06235736Recruiting
Do ACL tears cause weakness in the soleus muscle?
This study looks at whether people with ACL tears have weakness in a specific calf muscle called the soleus. If you have an ACL tear, you will do strength tests to compare with healthy individuals.
LiverpoolAges 18–55 - NCT04408885Recruiting
Rehab program for a torn ACL ligament
This study looks at a rehabilitation-focused treatment plan after an ACL (an important knee ligament) tear. It may help you by testing the best rehab approach for improving knee function and stability.
Aarhus NAges 18–50 - NCT06189573Enrolling by invitation
ACL repair: quadriceps vs patellar tendon graft
This trial compares two ways to rebuild a torn ACL using either a piece of your quadriceps tendon (with a small bone piece) or a piece of your patellar tendon (with bone). The goal is to find which graft works best for long-term stability and recovery.
Mexico City, Mexico CityAges 15–55 - NCT06178497Recruiting
5-Year Check-In After ACL Repair
This study checks on people who had ACL (anterior cruciate ligament) repair surgery 5 years ago to see how well their knee is doing. It looks at a specific type of ACL tear (a 'proximal' tear) and helps doctors understand long-term results.
Lille, Choisir Une RégionAges 18 years+ - NCT06099600Recruiting
ACL reconstruction study with follow-up via app
This trial is for people getting ACL (anterior cruciate ligament) surgery. It tests if tracking your recovery through questionnaires on a phone or tablet helps improve outcomes.
LyonAges 18 years+ - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT05501210Recruiting
Knee vibration therapy for ongoing front-of-knee pain after ACL surgery
This trial studies whether a vibrating device on the front of the knee can reduce persistent pain after ACL reconstruction. It may help people whose pain is focused in one knee and isn’t caused by arthritis or other knee problems.
Hong KongAges 18–60 - NCT05395767Recruiting
Living-donor tendon graft for ACL repair in teens
This study tests whether an ACL reconstruction using a tendon from a living donor works well and is safe in children and teens. It may help families compare this approach while closely tracking knee function after surgery.
Pembury, KentAges 8–17 - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25 - NCT04650568Enrolling by invitation
Stem cell treatment after ACL ligament surgery
This trial studies whether adding mesenchymal stem cells during ACL (knee ligament) reconstruction helps the knee heal better. You might be eligible if your ACL injury is recent and you’re having a specific type of graft surgery.
Chicago, IllinoisAges 18–60 - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18
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Common questions
- Are there clinical trials for anterior cruciate ligament rupture?
- Yes. Clin2 currently lists 62 recruiting anterior cruciate ligament rupture studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament rupture trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament rupture trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.