Clinical trials
Anterior Cruciate Ligament clinical trials
Below are recruiting anterior cruciate ligament clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06571240Recruiting
Turkish Activity Score Tool for ACL Surgery Patients
This study checks if a new Turkish version of an activity score (Tegner) is valid and reliable for people having ACL surgery. If you are having your first ACL repair and speak Turkish, you may be able to take part.
AnkaraAges 18 years+ - NCT06571227Recruiting
Understanding knee scores after ACL surgery
This study aims to find what a 'normal' knee score (Lysholm score) means for people after ACL surgery. It will help doctors know if your recovery is on track.
AnkaraAges 18 years+ - NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT06561035Enrolling by invitationPhase 3
Opioid-sparing study for ACL reconstruction
This study tests pain management options after ACL reconstruction to reduce the need for strong painkillers. It may help you recover with fewer side effects and lower risk of opioid dependence.
Skokie, IllinoisAges 14–85 - NCT06529692Recruiting
Split-belt treadmill training after ACL reconstruction
This study tests whether walking on a special split-belt treadmill (where each belt moves at a different speed) can help improve how your knee moves and feels after ACL reconstruction. The goal is to see if this training leads to better long-term knee health.
Ann Arbor, MichiganAges 14–45 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06235736Recruiting
Do ACL tears cause weakness in the soleus muscle?
This study looks at whether people with ACL tears have weakness in a specific calf muscle called the soleus. If you have an ACL tear, you will do strength tests to compare with healthy individuals.
LiverpoolAges 18–55 - NCT06240780Enrolling by invitation
Incrediwear recovery study for ACL and MCL surgery
This trial tests whether wearing Incrediwear clothing helps you recover faster after arthroscopic knee surgery for ACL or MCL tears. It is designed for people about to have surgery and who want to improve their healing process.
Oklahoma City, OklahomaAges 18–65 - NCT04408885Recruiting
Rehab program for a torn ACL ligament
This study looks at a rehabilitation-focused treatment plan after an ACL (an important knee ligament) tear. It may help you by testing the best rehab approach for improving knee function and stability.
Aarhus NAges 18–50 - NCT06193343Recruiting
Steps to prevent osteoarthritis after ACL surgery
This study tests whether increasing your daily steps after ACL reconstruction can help prevent knee osteoarthritis. It involves walking more and tracking your activity over time.
Athens, GeorgiaAges 16–40 - NCT06178484Recruiting
Surgery versus rehabilitation for a torn ACL
This study compares two ways to treat a tear of the anterior cruciate ligament (ACL) near the top of the knee. It looks at whether having surgery is better than a non-surgical approach with physical therapy. You may be eligible if your tear is recent and you have no other knee injuries.
Lille, Choisir Une RégionAges 18 years+ - NCT06178497Recruiting
5-Year Check-In After ACL Repair
This study checks on people who had ACL (anterior cruciate ligament) repair surgery 5 years ago to see how well their knee is doing. It looks at a specific type of ACL tear (a 'proximal' tear) and helps doctors understand long-term results.
Lille, Choisir Une RégionAges 18 years+ - NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05752695Enrolling by invitation
Rehab program for athletes with an ACL injury
This study looks at a rehab program (“Operation Korsband”) for athletes who have an ACL injury. It may help improve recovery and return to sport.
KalmarAges 12–55 - NCT05527171Recruiting
Virtual reality mindfulness after ACL knee surgery
This study uses a virtual-reality mindfulness meditation program to help improve fear and movement quality after ACL reconstruction. It may help you feel less afraid of movement and land more safely when you return to sports.
Chapel Hill, North CarolinaAges 14–25 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05391672Recruiting
Study for early surgery after a partial ACL tear
This trial looks at treatment options for people with a partial ACL ligament tear in the knee, including both recent and long-standing injuries. It may help to clarify the best early approach for healing and knee function, especially when there are no other ligament injuries.
AsyutAges 15–50 - NCT05412381RecruitingPhase 3
PRP after ACL injury to help prevent knee arthritis
This study tests whether PRP (platelet-rich plasma) given after an ACL injury and surgery can lower the chance of developing long-term knee arthritis. It may help protect the knee over time by targeting early healing after ACL reconstruction.
New York, New YorkAges 14–50 - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT03968913RecruitingEarly Phase 1
Biologic shot to prevent knee arthritis after ACL injury
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Los Angeles, CaliforniaAges 18–35 - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18
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Common questions
- Are there clinical trials for anterior cruciate ligament?
- Yes. Clin2 currently lists 148 recruiting anterior cruciate ligament studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.