Clinical trials
Anterior Cruciate Ligament clinical trials
Below are recruiting anterior cruciate ligament clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06936995Recruiting
Comparing pain relief methods for ACL surgery recovery
This trial tests two ways to manage pain after ACL reconstruction: a combination of medications (multimodal analgesia) versus a nerve block in the thigh (femoral block). The goal is to see which approach provides better pain control and recovery.
AnkaraAges 18–65 - NCT07128602Recruiting
Brain stimulation to help quadriceps after ACL surgery
This study tests whether a gentle, non-invasive brain stimulation can improve thigh muscle function in women recovering from ACL reconstruction. If you are between 2 and 6 months post-surgery, you may be able to join.
Glenside, PennsylvaniaAges 18–35 - NCT05470790Recruiting
Arabic questionnaire study for ACL knee injury athletes
This study uses Arabic versions of questionnaires to measure knee control and sports cutting/pivoting ability after a one-sided ACL (knee ligament) injury. It may help researchers better evaluate recovery and readiness for sports in Arabic-speaking athletes.
Dammam, Eastern ProvinceAges 18–45 - NCT07097077Recruiting
Brain changes after ACL surgery with special training
This study uses brain scans (fMRI) to see how a special type of movement training affects the brain after ACL surgery. If you've had an ACL repair and are active in sports, you may be eligible.
Bologna, BolognaAges 18–30 - NCT07049484Recruiting
ACL surgery with extra ligament reinforcement study
This study looks at how well an ACL reconstruction works when it also includes a second procedure (LET) to give extra support to the knee. It may help people who need this specific type of surgery have better stability and movement afterward.
BolognaAges 18–50 - NCT07041242Recruiting
ACL reconstruction outcomes in older vs. younger adults
This study compares how well a specific type of ACL knee surgery works in people over 50 versus those under 30. It looks at results and problems after surgery to see if the technique is safe and effective for older patients.
Bologna, BolognaAges 18 years+ - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT07009392Recruiting
Bacteria in the knee during ACL surgery
This study looks for bacteria inside the knee joint during ACL (anterior cruciate ligament) surgery, either for the first time or after a previous surgery. The goal is to learn more about the knee's natural bacteria, which might help improve recovery and prevent infections.
LyonAges 18 years+ - NCT06991192Recruiting
ACL surgery rehab with exercise and mental support
This study tests a rehab program that combines physical exercises with psychological support to help young athletes recover from ACL surgery and return to sports safely.
Bloomington, MinnesotaAges 15–25 - NCT06973642Recruiting
Home-based rehab after ACL surgery via phone
This trial tests whether a home-based rehab program using your phone can help people recover after anterior cruciate ligament (ACL) reconstruction. It aims to see if remote physical therapy is as effective as in-person sessions.
Jackson, MississippiAges 18 years+ - NCT06961292Enrolling by invitation
Knee ligament surgery study for ACL tears with extra rotation
This study compares two surgery techniques for ACL tears where the knee also twists too much inward. It aims to find which method leads to better long-term knee stability.
BeijingAges 18 years+ - NCT06910150Enrolling by invitation
Pain relief after knee surgery: electric stimulation study
This trial tests two types of mild electric stimulation (one with tiny needles, one without) applied to the thigh muscle to reduce pain in people who had ACL knee surgery in the last six weeks. The goal is to see if this can help you feel better and recover quicker.
Madrid, MadridAges 18–55 - NCT06566950Recruiting
Blood flow training for leg muscle health in athletes
This study tests a training method that uses light blood flow restriction to improve leg muscle structure. It is for young athletes (ages 15–35) who play high-level sports like martial arts, basketball, soccer, or futsal at least twice a week.
Denpasar, BaliAges 15–35 - NCT06868147Recruiting
Long-term results of a second ACL reconstruction using a tendon graft
This study looks at people who had a second surgery to fix a torn ACL in their knee. The surgery used a special technique with a tendon from the Achilles. Researchers want to see how well the knee works and looks on X-rays at least 2 years after that surgery.
BolognaAges 18–50 - NCT06827483Enrolling by invitation
Balance and thinking test for young adults after ACL surgery
This study looks at how thinking skills affect balance in young adults who had ACL repair surgery in the past 5-7 months, compared to healthy young adults. You will do balance tasks and answer some questions.
Durham, North CarolinaAges 18–25 - NCT06818201Recruiting
Brain stimulation for ACL surgery recovery
This study tests if a gentle, noninvasive brain stimulation called tDCS can improve how your brain controls leg muscles and speeds up recovery after ACL surgery.
Valencia, ValenciaAges 16–40 - NCT06688344Recruiting
Shock wave therapy after ACL surgery
This trial tests if adding focused shock wave therapy to standard rehab can improve recovery after ACL reconstruction using a hamstring graft. It may help reduce pain and speed up healing.
IstanbulAges 18–45 - NCT06662955Recruiting
Exercise with sound cues after ACL reconstruction
This study tests if adding sounds (like a metronome beat) to your rehab exercises helps your leg muscles work better after ACL reconstruction. It is for athletes who had their ACL surgery within the past 2 weeks and are ready to start moving.
Salaya, Changwat Nakhon PathomAges 18–35 - NCT06635668Recruiting
ACL injury risk screening study for athletes
This study screens healthy athletes aged 10 to 65 to understand what normal ACL injury risk looks like. It helps set a baseline so doctors can better identify those at higher risk.
Fargo, North DakotaAges 10–65 - NCT06636045Enrolling by invitation
Blood flow restriction after ACL surgery with quad graft
This study tests whether using a special blood flow restriction cuff after ACL surgery helps you recover faster and stronger. It is for people having ACL reconstruction using their own quadriceps tendon for the first time.
Kansas City, KansasAges 14–40 - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT05968729Recruiting
Study testing walking changes after ACL surgery
This study looks at how your walking pattern adapts when you follow a purposely uneven walking setup. It may help researchers understand recovery after ACL surgery and how to improve return-to-sport safety.
Storrs, ConnecticutAges 18–30
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Common questions
- Are there clinical trials for anterior cruciate ligament?
- Yes. Clin2 currently lists 148 recruiting anterior cruciate ligament studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.