Clinical trials
Aortic Valve Regurgitation clinical trials
Below are recruiting aortic valve regurgitation clinical trials, each written for real people, not researchers. We’re tracking 126 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06557798Recruiting
Second TAVI for failing aortic valve replacement
This trial is for people who have already had a TAVI (a minimally invasive aortic valve replacement) and now need a second procedure because the valve is failing. The study will test how well a redo TAVI works to fix the failing valve.
AalborgAges 18 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT07677410Recruiting
Aspirin alone vs. aspirin with warfarin after TAVR for aortic regurgitation
This trial tests whether taking aspirin alone is as safe and effective as taking aspirin with warfarin after a TAVR procedure for severe aortic regurgitation. It is for people who do not need long-term blood thinners for other conditions.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT06964035Enrolling by invitation
How original valve problem affects new valve's long-term health
This study looks at how the original problem with your aortic valve (narrowing, leaking, or both) might affect how long the replacement valve stays healthy. If you had both your aortic and mitral valves replaced, doctors want to track how well the new valve works over time.
Maastricht, MaastrichtAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT03003299Recruiting
Valve replacement for failing aortic bioprosthetic valves
This trial studies a new “valve-in-valve” procedure to treat a failing aortic bioprosthetic valve. It may help people improve blood flow through the heart valve and reduce valve-related problems.
Phoenix, ArizonaAges Any age - NCT03143361Recruiting
Aortic valve replacement registry for adults needing valve surgery
This study follows adults who are having aortic valve replacement to better understand outcomes across different hospitals in Europe. It may help your care team compare results and improve future treatment planning.
VeronaAges 18 years+ - NCT03836521Recruiting
Registry for valve replacement in bicuspid aortic stenosis patients
This registry collects information about adults with severe narrowing of the aortic valve caused by a bicuspid (two-leaflet) valve shape, especially if symptoms are present. It may help doctors better understand who benefits from a catheter-based valve replacement (TAVR).
Los Angeles, CaliforniaAges 19–129 - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT04464655Recruiting
10-minute heart MRI protocol for people with heart conditions
This study uses a short, 10-minute heart MRI to check how well it works for people who need a clinically indicated heart scan. It may help streamline heart MRI testing, making exams faster while still providing useful heart information.
Montreal, QuebecAges 18 years+ - NCT04797572Recruiting
Testing a tool to measure the aortic valve during surgery
This trial evaluates a measuring tool used during aortic valve surgery. It may help surgeons size the valve opening more accurately when treating valve leakage or a dilated (enlarged) ascending aorta.
BrusselsAges 18–80 - NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT05439863Recruiting
Valve procedure trial for severe aortic valve problems
This trial studies people with severe aortic valve disease who will receive a catheter-based valve replacement (TAVR). It aims to check how well this approach works for fixing a narrowed or leaky aortic valve, and to monitor outcomes afterward.
Nanjing, JiangsuAges 18 years+ - NCT05438862Recruiting
Early aortic valve surgery versus watchful waiting
This trial compares two approaches for people with a leaking aortic valve but no symptoms: early surgery or careful monitoring (“watchful waiting”). It aims to see which strategy better prevents future heart problems and when surgery is most helpful.
AalstAges 18 years+ - NCT05459233Recruiting
Testing ultrasound-guided valve settings after valve-in-valve TAVR
This trial compares two ways to check and fine-tune how well a new valve is working after a “valve-in-valve” TAVR procedure. It looks to see whether measurements from ultrasound of the heart (Doppler echocardiography) match results from a catheter test, which could help guide safer, more accurate valve care.
San Francisco, CaliforniaAges 18 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT06009588Recruiting
Comparing Two Heart Valve Types for Aortic Stenosis with Aorta Dilation
This trial tests two types of artificial heart valves—one that expands on its own and one expanded with a balloon—in people with a widened upper aorta. The goal is to see which works better for your condition.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06049654Recruiting
Comparing Allegra and Sapien valves for valve-in-valve procedure
This trial tests two different replacement heart valves (Allegra and Sapien) to see which works better for people who need a new valve placed inside a previously implanted surgical valve. It aims to help patients with a failing biological aortic valve who are already scheduled for this procedure.
AlessandriaAges 18 years+ - NCT06101888Recruiting
New Heart Valve for Severe Aortic Leak
This study is testing a new, less invasive heart valve system (TaurusTrio) for people with severe aortic regurgitation (a leaky aortic valve) who cannot have open-heart surgery. It aims to see if the valve is safe and works well to improve symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06235385Recruiting
European study on multiple and mixed valve disease
This study looks at people with multiple or mixed heart valve disease (moderate or severe) using echocardiography. It aims to learn more about how these conditions affect patients and help guide future care.
Paris, Île-de-France RegionAges 18 years+ - NCT06381271Recruiting
TAVR for severe aortic valve regurgitation
This trial tests a procedure called TAVR to replace the aortic valve in people with severe aortic regurgitation (a leaky valve). It may help you if you have this condition and prefer a less invasive option than open-heart surgery.
Xi'an, ShannxiAges 18 years+
Hear when a new Aortic Valve Regurgitation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for aortic valve regurgitation?
- Yes. Clin2 currently lists 126 recruiting aortic valve regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.