Clinical trials
Bicuspid Aortic Valve clinical trials
Below are recruiting bicuspid aortic valve clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07413965Recruiting
Transcatheter vs surgical valve replacement for severe bicuspid aortic stenosis
This trial compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve. If you're 50 or older and need a new valve, this study can help figure out which approach works best.
Los Angeles, CaliforniaAges 50 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+ - NCT06991517Recruiting
TAVR sizing study for bicuspid aortic valve patients
This study tests a special sizing method (ABC algorithm) to help doctors select the right valve for people with a bicuspid aortic valve. It aims to improve outcomes for those getting a Sapien 3 valve through a catheter (TAVR).
St Leonards, New South WalesAges Any age - NCT03139786Recruiting
Heart valve follow-up study for bicuspid aorta patients
This study follows patients who have a bicuspid aortic valve—a heart valve with two leaflets instead of three. Researchers track how this condition changes over time to better understand its long-term effects and help guide future care.
Amiens, PicardieAges 18 years+ - NCT03836521Recruiting
Registry for valve replacement in bicuspid aortic stenosis patients
This registry collects information about adults with severe narrowing of the aortic valve caused by a bicuspid (two-leaflet) valve shape, especially if symptoms are present. It may help doctors better understand who benefits from a catheter-based valve replacement (TAVR).
Los Angeles, CaliforniaAges 19–129 - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT04722796Recruiting
TAVR for bicuspid aortic valve with a specific device
This study tests a “solution” approach using a self-expanding valve during TAVR (a less invasive way to replace a narrowed aortic valve). It aims to improve how well the valve fits and works in people with a specific heart valve shape (bicuspid aortic stenosis).
Bengbu, AnhuiAges 60 years+ - NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT07695545Recruiting
Lipid metabolism study in ascending aortic aneurysm
This study looks at how fat metabolism and cell energy centers (mitochondria) work in patients having surgery for an ascending aortic aneurysm. It aims to understand differences between people with bicuspid or tricuspid aortic valves.
DijonAges 18 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age - NCT06153407Recruiting
Genetic test for early valve disease in bicuspid aortic valve
This study looks at how genes may affect the risk of calcium buildup in the aortic valve in people with a bicuspid aortic valve. By joining, you help researchers find better ways to predict and manage this heart condition.
SeoulAges 19–80 - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06596460Recruiting
Imaging study after TAVI valve replacement
This study collects extra imaging data from 40 people who are already scheduled for a routine TAVI procedure to replace a narrowed aortic heart valve. The goal is to better understand the valve's structure and function using scans.
London, EnglandAges 18 years+ - NCT06688448Recruiting
New biologic aortic valve replacement study
This study is testing a new generation of biologic (tissue) replacement valves for the aortic valve in adults aged 18 to 65. It aims to see how well these newer devices work compared to standard options.
São Paulo, São PauloAges 18–65 - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT06802016Recruiting
Study of Chinese congenital bicuspid aortic valve
This study looks at people with a bicuspid aortic valve (a valve with two flaps instead of three) in Chinese patients. It collects information about this condition to better understand it.
Shanghai, Shanghai MunicipalityAges 14–60 - NCT06817148Recruiting
TAVR vs surgery for bicuspid aortic valve disease
This study compares two treatments for severe aortic stenosis in people with a bicuspid aortic valve: transcatheter aortic valve replacement (TAVR, a less invasive procedure) and surgical aortic valve replacement (SAVR, open-heart surgery). The goal is to see which approach works better for this specific condition.
Los Angeles, CaliforniaAges 50 years+ - NCT06830499Recruiting
Sapien 3 valve for younger Chinese patients with severe aortic stenosis
This trial tests a newer artificial heart valve (Sapien 3) placed through a small tube in the leg, for younger people (50–70) with severe aortic stenosis. It aims to see if this less invasive option works well in this age group.
Xi'an, ShaanxiAges 50–70 - NCT06869954Recruiting
Bicuspid aortic valve repair: comparing two surgical techniques
This trial tests two different ways to repair a leaky bicuspid aortic valve (a valve with two flaps instead of three). The goal is to see which repair method works better. If you need surgery for a severely leaking valve and your valve is the right shape, you may be able to join.
Augsburg, BavariaAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT07366671Recruiting
Testing a new wire for heart valve replacement safety
This trial tests a special wire to monitor heart function during a less invasive valve replacement procedure (TAVI). It aims to improve safety and understanding of the heart's response during the procedure.
Eindhoven, North BrabantAges 50 years+ - NCT01756222Recruiting
Bicuspid aortic valve registry for adults
This study is a registry that collects health information from adults with bicuspid aortic valve disease. It may help doctors better understand outcomes and guide future care for patients and families affected by this condition.
Ann Arbor, MichiganAges 18 years+ - NCT02306200Recruiting
A study to improve heart and aorta health
This trial looks at ways to improve cardiovascular (heart and blood vessel) health, especially conditions that affect the aorta, such as aneurysms, or vascular problems that may run in families. If you have an aortic-related or other cardiovascular diagnosis (or you’re a healthy comparison participant), you may be invited to take part in this health-improvement program.
Ann Arbor, MichiganAges Any age
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Common questions
- Are there clinical trials for bicuspid aortic valve?
- Yes. Clin2 currently lists 43 recruiting bicuspid aortic valve studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bicuspid aortic valve trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bicuspid aortic valve trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.