Clinical trials
Arthroplasty clinical trials
Below are recruiting arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06754150Recruiting
Shoulder Innovations shoulder replacement registry study
This study follows people who have or will have a shoulder replacement using a Shoulder Innovations device. Researchers will collect information on how well the device works and how your shoulder feels over time.
Birmingham, AlabamaAges 18 years+ - NCT06748885Recruiting
Mpact 3D metal hip replacement study
This trial tests a new 3D-printed metal hip implant for people who need a first-time hip replacement. It aims to see how well the implant works and helps you recover.
NantesAges 18–75 - NCT06747494Recruiting
Comparing general vs spinal anesthesia for hip or knee replacement
This study compares two types of anesthesia (general and spinal) for people having a total hip or knee replacement. The goal is to see which approach is better for recovery and overall outcomes.
Miami, FloridaAges 18 years+ - NCT06733597Recruiting
Bone density change after knee replacement with or without cement
This study looks at how bone density in the thigh bone changes after knee replacement surgery, comparing two ways of attaching the new joint (with cement or without). It may help people who have normal bone density or early bone thinning but not full osteoporosis.
Madison, WisconsinAges 55 years+ - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06640764Recruiting
Study of Medacta SMS hip stem for hip replacement
This study tests a specific hip implant (the Medacta SMS stem) for people needing a total hip replacement. It aims to see how well the implant works for patients with hip pain or disability from arthritis, injury, or other hip conditions.
Saint-JeanAges 18–85 - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06623149Enrolling by invitation
Surgery vs. non-surgery for knee arthritis
This study compares non-surgical treatments with knee replacement surgery for people with knee osteoarthritis. It aims to find out which approach works better.
Copenhagen, CopenhagenAges Any age - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT06627673Recruiting
A new knee implant study for severe arthritis
This study compares a new plastic-and-metal knee implant to a standard metal one for people with severe knee arthritis. If you need a total knee replacement and your knee is not too bent or twisted, you may be a candidate.
Leawood, KansasAges 18 years+ - NCT06626490Recruiting
Follow-up study of the Prevision hip stem
This study follows patients who got a Prevision hip stem during revision hip surgery to see how well different versions of the stem perform. The goal is to help doctors choose the best options for you.
HanoverAges 18 years+ - NCT06627699Recruiting
Study of the Freedom Total Knee System for knee replacement
This study is for people getting a total knee replacement for the first time. It looks at how well the Freedom Total Knee System works in everyday life.
Leawood, KansasAges 18 years+ - NCT05278520Recruiting
Study of hip arthritis types during hip replacement surgery
This study looks at differences inside the hip joint and in body cells when people have hip arthritis or rheumatoid arthritis and receive a hip replacement. Researchers hope this can improve understanding and future treatments for these conditions.
Turku, Southwest FinlandAges 18–74 - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT06576583RecruitingPhase 2
Cartilage graft for kneecap arthritis
This trial tests a new graft made from lab-grown cartilage to treat knee pain under the kneecap. It compares the graft to standard surgery for people with moderate-to-severe kneecap arthritis who haven't improved with other treatments.
ViennaAges 18–70 - NCT06563531Recruiting
Do compression stockings help after hip or knee replacement?
This trial looks at whether compression stockings are still needed for people who have a new hip or knee joint and are following a modern "fast-track" recovery program. It aims to find out if these stockings are necessary to prevent blood clots when people are up and moving quickly after surgery.
BrestAges 18 years+ - NCT06565910RecruitingPhase 4
Pain relief after hip surgery: long-acting vs standard numbing medicine
This study tests if a long-acting numbing medicine (bupivacaine liposome) combined with a standard numbing medicine works better for pain control after hip fracture surgery. It compares two different combinations to see which provides more effective pain relief.
Wuhan, HubeiAges 18–60 - NCT06527664Recruiting
Custom hip implant for failed arthritis treatments
This trial tests a custom-made hip socket implant for people who have had a failed hip replacement or arthritis treatment. It aims to see if a personalized implant can provide a better solution.
BolognaAges 18 years+ - NCT06520085Recruiting
Using a phone app to improve recovery after shoulder surgery
This trial tests whether a personalized mobile app helps people recover better after reverse shoulder replacement surgery. If you use a smartphone or tablet, the app may guide your recovery and track your progress.
Venlo, LimburgAges 18 years+ - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT04210284Recruiting
Oral nutrition support before hip or knee replacement
This trial tests whether an oral nutrition plan given before elective hip or knee replacement can help people with low nutrition (“malnutrition”) do better after surgery. If you’re a candidate for surgery and meet lab signs of poor nutrition, you may be asked to take an oral supplement by mouth.
New York, New YorkAges 55 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT06371833Recruiting
Shoulder replacement study for arthritis or rotator cuff tears
This study is testing two types of shoulder replacement implants (one for arthritis and one for rotator cuff tears) to see how well they work over time. It may be a good option if you have severe shoulder pain from arthritis or a torn rotator cuff.
Cattolica, RiminiAges 18 years+
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Common questions
- Are there clinical trials for arthroplasty?
- Yes. Clin2 currently lists 450 recruiting arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.