Clinical trials
Arthroplasty clinical trials
Below are recruiting arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06952738Recruiting
Studying bacteria around hip or knee fracture repairs
This trial looks for bacteria around the implant in patients who need surgery for a broken bone near a hip or knee replacement. It aims to learn if these infections affect healing.
Chicago, IllinoisAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06951178Enrolling by invitation
Long-term safety of a custom jaw joint implant
This study checks the long-term safety and how well a new jaw joint implant (for the TMJ) works. It follows patients who are already getting this implant to see how they do over time.
Copenhagen, Capital Region of DenmarkAges Any age - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06917365Recruiting
Testing a new liner for SERF hip replacements
This trial is testing a new liner (the inner part) for a specific brand of hip replacement called SERF. It's looking at how well it works in people who need a total hip replacement.
DijonAges 18 years+ - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT06920186Recruiting
Extra nerve blocks for knee replacement pain
This study compares two ways to manage pain after knee replacement surgery: one uses a nerve block around the knee (adductor canal block), and the other adds an extra shot or nerve block. The goal is to see which approach works better for controlling pain and helping you recover.
Quincy-sous-SénartAges 18 years+ - NCT06903767Enrolling by invitation
Automated vs manual tool study for hip replacement
This trial tests whether an automated surgical tool is better than a manual one for putting in hip replacement parts. If you are having a planned first-time hip replacement and are over 18, you might be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT05046600Recruiting
Hand and wrist implant registry for eligible adult patients
This registry collects information about people who need hand or wrist surgery using specific Arthrex implants. It helps the company and doctors learn how these implants are used and how patients do during healing.
Phoenix, ArizonaAges 18 years+ - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT06876350Recruiting
Wood cast vs. thermoplastic splint after thumb surgery
This trial compares two types of casts used after thumb joint replacement surgery to see which one works better for recovery. Participation lasts about 6 weeks.
Tampa, FloridaAges 18 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06831045Recruiting
Bikini vs Straight Incision for Hip Replacement
This study compares two types of skin cuts (a bikini-line incision vs a straight side incision) for total hip replacement through the front of the hip. It is designed for people with a BMI of 30 or higher to see which incision heals better and leads to fewer wound problems.
Miami, FloridaAges 18 years+ - NCT05556759Recruiting
Two types of hip pain nerve blocks during hip surgery
This trial compares two nerve-block techniques to see which one gives better pain control during and after total hip replacement surgery. It may help you feel more comfortable and possibly reduce the need for pain medicine.
Zagazig, AlsharqiaAges 50–80 - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT06803914Recruiting
Returning to sports after hip replacement
This study looks at how people move and return to sports after total hip replacement surgery. If you are an active person planning to have a hip replacement, this trial may help understand your recovery.
MérignacAges 18–65 - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT06800846Enrolling by invitationPhase 4
Pain relief after knee replacement: injection methods compared
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Khlong Luang, Changwat Pathum ThaniAges 50–80 - NCT06268795Recruiting
Comparing biopsy vs. aspiration for shoulder/elbow revision surgery
This study compares two methods—biopsy (taking a small tissue sample) and aspiration (drawing fluid)—to see which one better detects infection in people having repeat shoulder or elbow replacement surgery. The results will help doctors choose the best test for future patients.
Wigan, LancashireAges 18 years+
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Common questions
- Are there clinical trials for arthroplasty?
- Yes. Clin2 currently lists 450 recruiting arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.