Clinical trials
Bipolar clinical trials
Below are recruiting bipolar clinical trials, each written for real people, not researchers. We’re tracking 241 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT05828056Recruiting
Predicting mood episodes in bipolar disorder with a smartwatch
This study uses a smartwatch and smartphone to track daily patterns and predict when manic or depressive episodes might happen in people with bipolar disorder. It aims to help patients and doctors better manage the condition.
TaipeiAges 20–60 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05838274Recruiting
Study of alcohol effects and brain scans in bipolar disorder
This study gives a controlled amount of alcohol and uses brain MRI scans to understand how alcohol affects people with bipolar disorder. It may help researchers find brain and behavior patterns that explain differences in alcohol responses.
Austin, TexasAges 21–26 - NCT04080778Recruiting
Magnetic seizure treatment for severe bipolar or hard-to-treat depression
This trial studies whether a seizure-like therapy using magnet stimulation can quickly reduce severe depressive symptoms in people with bipolar depression or treatment-resistant depression. It may help when depression is intense and hasn’t improved enough with at least two antidepressant medicines.
Houston, TexasAges 22–85 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05627492Recruiting
DBT booster sessions for youth at bipolar risk
This study adds short “booster” sessions to Dialectical Behavior Therapy (DBT) for young people who already took part in a prior DBT study, including those with bipolar symptoms or strong family risk. It aims to see if extra DBT support helps mood and coping over time.
Toronto, OntarioAges 14–25 - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT00201526Recruiting
BRAIN study for people who can consent
This study enrolls patients who are able to understand the study and voluntarily agree to participate in writing. It aims to learn from participants to improve research and innovation related to bipolar illness and care.
TrondheimAges Any age - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05296356RecruitingPhase 2
Study drug for bipolar depression in people already on mood stabilizers
This trial tests whether OSU6162 can improve depressive symptoms in adults with bipolar depression who are already taking a stable mood-stabilizing medicine. It also checks safety by closely monitoring mood, heart rhythm, and other health factors during the study.
GothenburgAges 18–65 - NCT05303064RecruitingPhase 3
Study of weight gain medicine for teens with certain mood or psychosis
This Phase 3 study tests a treatment aimed at reducing unhealthy weight gain in teens with schizophrenia or bipolar I disorder, using changes in BMI (a height-and-weight measure). It may help families who are concerned about weight changes that can happen with some psychiatric medicines.
Dothan, AlabamaAges 10–17 - NCT05199870Enrolling by invitation
Long-term follow-up for specific hip implant parts
This study follows people who had a particular bipolar hip implant (RingLoc cup and/or Endo II head) placed during a hemi-hip replacement surgery at least 8 years ago. It checks how well the implants keep working over time and why.
Falls Church, VirginiaAges 18 years+ - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT05153369Recruiting
DBT-based care for youth at risk for bipolar disorder
This study tests a structured, “DBT-informed” care program for young people who either have bipolar disorder or are at family risk for it. It may help by offering closer, organized support aimed at preventing or reducing mood problems.
Toronto, OntarioAges 13–23 - NCT04917419Recruiting
Light therapy and talk therapy for sleep issues in bipolar disorder
This trial tests whether bright light therapy (luminotherapy) and/or structured education and coaching (psychoeducation) can improve sleep and daily body rhythm in people with bipolar disorder. It may help if your bipolar symptoms come with troublesome sleeping patterns.
PoitiersAges 18–65 - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT04704505RecruitingPhase 2
Testosterone-like treatment plus radium for bone-spread prostate cancer
This trial studies whether adding a testosterone-related therapy (BAT) to radium-223 can better control prostate cancer that has spread mainly to the bones. It may help shrink tumors in the bone and slow PSA rises, which are a common marker of prostate cancer activity.
Baltimore, MarylandAges 18 years+ - NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT04432116Recruiting
Virtual reality training for schizophrenia and bipolar symptoms
This study looks at whether virtual reality and time-based training can improve symptoms for people with schizophrenia or bipolar disorder. You may do virtual-reality tasks as part of your care plan while the team tracks changes over time.
StrasbourgAges 18–60 - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99 - NCT03829787Recruiting
Study of attention and reward signals in bipolar disorder
This study looks at how people with bipolar disorder pay attention and respond to rewards, including whether anxiety or substance use is also present. It uses eye-tracking and related tests to better understand brain patterns that may affect mood and decision-making.
Cleveland, OhioAges 18 years+ - NCT05480150Recruiting
Study of brain and mood in people with depression or bipolar disorder
This study is following and assessing people with major depression or bipolar disorder to better understand the condition and how the brain relates to symptoms. It may help researchers develop more targeted support by comparing brain and health information over time.
Hangzhou, ZhejiangAges 16–65 - NCT03635645Recruiting
Testing stimulation in people with an implanted retinal prosthesis
This study looks at how retinal stimulation works for people who already have an Argus II retinal prosthesis implanted. It may help researchers understand how well the stimulation creates a visual perception and how reliably people can do the required testing.
Ann Arbor, MichiganAges 25–89
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Common questions
- Are there clinical trials for bipolar?
- Yes. Clin2 currently lists 241 recruiting bipolar studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.