Clinical trials
Bipolar clinical trials
Below are recruiting bipolar clinical trials, each written for real people, not researchers. We’re tracking 242 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT07108257Recruiting
Focused ultrasound for bipolar depression
This trial uses sound waves guided by MRI to target a small brain area. It aims to help people with bipolar depression that hasn't improved with standard treatments.
Toronto, OntarioAges 18–65 - NCT07121894Recruiting
Ketogenic diet for bipolar depression
This study tests whether a high-fat, low-carbohydrate (ketogenic) diet can help improve depression symptoms in people with bipolar I or II disorder. You would work with the study team to change your diet while continuing your current mood-stabilizing medications.
Rochester, MinnesotaAges 18–50 - NCT07140913RecruitingPhase 3
Testing KarXT for bipolar I mania with mood stabilizers
This study tests whether adding KarXT to lithium, valproate, or lamotrigine helps calm manic episodes in people with bipolar I disorder. It aims to see if the combination is safe and works better than the mood stabilizer alone.
Bentonville, ArkansasAges 18–65 - NCT07194278Recruiting
Blue-blocking glasses for bipolar mania
This study tests whether special blue-blocking glasses can help reduce manic symptoms in people with bipolar disorder who are currently in a manic episode. You would wear the glasses for several hours a day, and the study would check if your symptoms improve.
Paris, FranceAges 18 years+ - NCT07213492Recruiting
Support program for young adults with bipolar disorder
This study tests a program to help young adults with a recent bipolar diagnosis move from hospital back to their community. You would get education sessions and support from peers to make the transition smoother.
Hamilton, OntarioAges 18–35 - NCT07221864Recruiting
Emotions and brain activity in bipolar disorder
This study uses brain scans to understand emotions in bipolar disorder. It compares people with bipolar who are currently depressed or in a mixed state to healthy volunteers, and involves up to two visits to the research center.
Tulsa, OklahomaAges 18–65 - NCT07263191Recruiting
Olanzapine study for bipolar disorder
This study looks at how well patients with bipolar disorder do while taking the medication olanzapine. You will continue your regular treatment, and answer questions about your experience.
SeongnamAges 19 years+ - NCT07266545RecruitingPhase 4
RNA markers for antidepressant response in depression
This study looks at how RNA might help predict which antidepressant works best for you. It tests two medications: vortioxetine and cariprazine, in people with major depressive disorder or bipolar depression.
Rochester, MinnesotaAges 18–65 - NCT07306468Recruiting
Exercise and lung health in schizophrenia and bipolar disorder
This study looks at how schizophrenia or bipolar disorder affects your ability to exercise, your lung function, and overall quality of life. It compares people with these conditions to healthy volunteers.
Çankırı, ÇankırıAges 18–65 - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT00201526Recruiting
BRAIN study for people who can consent
This study enrolls patients who are able to understand the study and voluntarily agree to participate in writing. It aims to learn from participants to improve research and innovation related to bipolar illness and care.
TrondheimAges Any age - NCT02242110Recruiting
Brief treatment to reduce trauma nightmares in bipolar adults
This trial tests a short therapy to help adults who have frequent trauma-related nightmares. It focuses on people with bipolar disorder whose nightmares have been happening regularly for at least a month.
Tulsa, OklahomaAges 18 years+ - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT07472075RecruitingPhase 2
Melatonin vs placebo for bipolar disorder
This trial tests whether taking melatonin (a natural sleep hormone) helps stabilize mood in people with bipolar disorder compared to a placebo (a pill with no active ingredient). It may help improve sleep and mood stability.
FrederiksbergAges 18–70 - NCT07556692Recruiting
Home Brain Stimulation for Bipolar Depression
This study tests whether a device you use at home can help reduce depression symptoms in people with bipolar disorder. The device uses gentle electrical stimulation on the scalp to potentially improve mood.
LondonAges 18 years+ - NCT07573839Recruiting
Predicting bipolar disorder relapse using voice and video analysis
This study uses artificial intelligence to analyze speech patterns and facial expressions from people with bipolar disorder to predict who might have a relapse. If successful, it could help doctors identify warning signs earlier and prevent episodes before they happen.
ShanghaiAges 18–64 - NCT07589647Recruiting
Brain Stimulation for Bipolar Disorder and Weight Management
This study tests whether a small electrical stimulation device targeting a specific brain region (the suprachiasmatic nucleus) can help improve metabolic health and weight in people with stable bipolar disorder who also have obesity. The goal is to see if this approach is safe and effective.
Hangzhou, ZhejiangAges 18–45 - NCT07627178Recruiting
Comparing laser treatments for enlarged prostate
This study compares three different surgical laser techniques to treat benign prostate enlargement (BPH) that causes severe urinary symptoms and hasn't improved with medication. The goal is to find which method is safest and works best for large prostates.
Tanta, Gharbia GovernorateAges Any age - NCT07648888Recruiting
Water Vapor Therapy Versus Bipolar Surgery for Enlarged Prostate
This trial compares two minimally invasive surgical treatments for benign prostatic hyperplasia (an enlarged prostate that causes urinary problems). Both approaches aim to relieve urinary symptoms while preserving your ability to ejaculate normally.
Banī Suwayf, Beni Suweif GovernorateAges 50 years+ - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT06011460Enrolling by invitation
Observing clozapine safety for bipolar depression
This study is testing whether clozapine, a medication usually used for schizophrenia, is safe for treating hard-to-treat depression in people with bipolar disorder. It may help if you have not found relief from other treatments.
Gdansk, Pomeranian VoivodeshipAges 18–65 - NCT05199870Enrolling by invitation
Long-term follow-up for specific hip implant parts
This study follows people who had a particular bipolar hip implant (RingLoc cup and/or Endo II head) placed during a hemi-hip replacement surgery at least 8 years ago. It checks how well the implants keep working over time and why.
Falls Church, VirginiaAges 18 years+ - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65
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Common questions
- Are there clinical trials for bipolar?
- Yes. Clin2 currently lists 242 recruiting bipolar studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.