Clinical trials
Brain Disorder clinical trials
Below are recruiting brain disorder clinical trials, each written for real people, not researchers. We’re tracking 311 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02472028RecruitingPhase 4
Lower blood pressure to protect the brain in older adults
This study tests whether better blood pressure control can slow changes seen on brain scans in older people. It focuses on people with high blood pressure and “wear-and-tear” type brain lesions on MRI.
Bordeaux, Pellegrin Hospital GroupAges 60–88 - NCT03270059RecruitingPhase 2
MRI with special contrast to study brain and other CNS problems
This trial tests whether two special MRI contrast medicines—gadolinium and ferumoxytol—can better diagnose problems in the brain or central nervous system. It may help doctors identify what’s causing symptoms or abnormal brain findings.
Portland, OregonAges 10 years+ - NCT07010614Recruiting
Brain stimulation for memory in schizophrenia
This trial uses brain stimulation to target memory areas in people with schizophrenia or related conditions. It aims to see if this can help improve symptoms.
Stanford, CaliforniaAges 18–65 - NCT06473285Recruiting
Esketamine for consciousness in prolonged disorders of consciousness
This trial tests whether a drug called esketamine can help improve brain activity in people with long-term disorders of consciousness. It may help doctors understand how the brain recovers.
BeijingAges 18–65 - NCT04443179Recruiting
Baby brain scans in England to study early development
This study does brain imaging (brain scans) in babies to better understand early brain development and how factors like family history and COVID-19 might relate to development. It may help researchers learn which babies could need extra support later.
LondonAges 16–75 - NCT07614074Recruiting
Understanding Recovery from Coma and Unconsciousness
This study follows patients who have been in a coma (deep unconsciousness) for at least 24 hours due to a brain injury. Researchers will track how patients recover over time to better understand which factors help predict who will wake up and how well they'll recover.
San Francisco, CaliforniaAges 18 years+ - NCT04631042Recruiting
Study how the brain relates to impulsivity and compulsivity
This study looks at how brain function and structure relate to impulsive and compulsive behaviors. It may help researchers understand what drives these behaviors and who may benefit from future mental health treatments.
Bethesda, MarylandAges 6–80 - NCT06568536Recruiting
EEG Study to Predict Recovery After Brain Injury
This study uses a special EEG test to measure brain activity in people who are not fully conscious after a recent brain injury. The goal is to find better ways to know if someone will wake up and recover thinking abilities.
Boston, MassachusettsAges 18 years+ - NCT06897553Recruiting
ACT for Better Mental Health with Neurologic Illness
This study tests a type of talk therapy (ACT) to help people with neurological conditions like Parkinson’s, MS, or epilepsy feel better emotionally. It's for those who are struggling with depression, anxiety, or stress and are ready to work on their mental health.
BielefeldAges 18 years+ - NCT00004577Recruiting
New Brain Imaging Methods Research Study
This research study tests new ways to take detailed pictures of your brain using MRI (a safe imaging machine). You'll help researchers develop better imaging methods by lying still in the scanner for up to 2 hours.
Bethesda, MarylandAges 18–120 - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT06355778Recruiting
Brain and Opioid Use Study
This study uses brain scans to understand how adversity affects opioid use and recovery. It compares people with opioid use disorder on buprenorphine, people taking buprenorphine for chronic pain, and healthy volunteers.
Ann Arbor, MichiganAges 18–55 - NCT03233646Recruiting
Retina scans in memory and nerve disorders
This study uses pictures of the back of your eye (retinal imaging) to look for differences in people with neurodegenerative diseases and compares them with people without these conditions. It may help researchers understand eye changes that could connect to brain or nerve health.
Durham, North CarolinaAges 18 years+ - NCT03578003Recruiting
Bright morning light to improve sleep in veterans
This study tests whether using bright morning light can improve sleep quality in veterans. You may be able to join if you’re not already using a light box and you don’t have certain eye or mood conditions.
Portand, OregonAges 18 years+ - NCT04004169Recruiting
Closed-loop deep brain stimulation for long-lasting depression
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
San Francisco, CaliforniaAges 22–70 - NCT04783103Recruiting
Brain scan study of stimulation for depression in older adults
This is a pilot study that uses brain imaging to see how a brain “neuromodulation” approach may affect depression in people age 65 and older. You would be screened for depression severity, medication history, and safety limits, and then be asked to keep your depression medicines stable during the study.
Jette, Brussels CapitalAges 65 years+ - NCT06126627Recruiting
Brain and voice study for teachers with vocal fatigue
This study looks at how vocal fatigue affects the brain and voice in teachers. It uses MRI and voice tests to understand these changes.
BonnAges 21–39 - NCT07459699Recruiting
Probiotics for kids with mild ADHD
This study tests whether a probiotic supplement can help children with mild ADHD by improving communication between the gut and the brain. It may offer a natural way to support focus and behavior.
ShanghaiAges 8–11 - NCT07556692Recruiting
Home Brain Stimulation for Bipolar Depression
This study tests whether a device you use at home can help reduce depression symptoms in people with bipolar disorder. The device uses gentle electrical stimulation on the scalp to potentially improve mood.
LondonAges 18 years+ - NCT06097013Enrolling by invitation
Brain function study for consciousness disorders
This trial is testing a brain function evaluation system to help understand and possibly improve care for people with disorders of consciousness caused by brain injury, stroke, or lack of oxygen. It is for both acute (recent) and prolonged (lasting) cases.
BeijingAges 14–60 - NCT05015881Enrolling by invitationPhase 2/Phase 3
Brain and heart scans in alcohol use disorder
This study uses special brain and heart scans to see how sugar (glucose) is used in people with alcohol use disorder compared with people without it. It may help researchers understand the brain–heart connection in alcohol use disorder.
Philadelphia, PennsylvaniaAges 21–65 - NCT04354077Recruiting
Deep brain stimulation for opioid use disorder cravings
This trial studies whether deep brain stimulation (a device that delivers small electrical signals to the brain) can reduce cravings and improve symptoms in adults with opioid use disorder. You may be eligible if you have a long history of opioid dependence and have tried multiple treatment options without lasting success.
Pittsburgh, PennsylvaniaAges 22–65 - NCT05823454Recruiting
Testing brain-connection changes during propofol sedation
This study looks at how the brain network connects during propofol sedation in people with long-lasting disorders of consciousness. It may help doctors understand brain function in these conditions and improve how care is guided during procedures.
BeijingAges 18–65 - NCT00009243Recruiting
Understanding How Strokes Develop: A Research Study
This study follows people who have had or are at risk for stroke to understand what causes strokes and how they develop over time. By participating, you help researchers learn more about stroke prevention and treatment.
Washington D.C., District of ColumbiaAges 18–120
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Common questions
- Are there clinical trials for brain disorder?
- Yes. Clin2 currently lists 311 recruiting brain disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.