Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,017 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06727032Enrolling by invitation
Ai detection of brain metastases on MRI
This trial tests an artificial intelligence tool that automatically spots cancer spread to the brain on MRI scans. It may help doctors find brain metastases faster and more accurately for people with cancer outside the brain.
AmsterdamAges 18 years+ - NCT06147999Recruiting
Biophoton therapy for brain disorders
This trial tests a biophoton therapy, a light-based treatment, for people with brain disorders. It aims to see if this non-invasive approach can help improve symptoms.
Butler, PennsylvaniaAges 18 years+ - NCT05322343Recruiting
Study biobank and brain health in people age 55–80
This study collects blood samples to build a biobank and learn how brain health changes with age. Some participants may also do an MRI scan to better understand brain changes and immune response.
Bordeaux, BordeauxAges 55–80 - NCT06660225Recruiting
Deep brain stimulation for severe OCD
This trial tests if deep brain stimulation (a surgical treatment that uses electrical pulses to adjust brain activity) can help people with severe obsessive-compulsive disorder (OCD) that has not improved with other treatments. It is for adults aged 22 to 75 who have had OCD symptoms for over 5 years.
Dallas, TexasAges 22–75 - NCT06649058RecruitingPhase 2
Study on combining drugs and radiation for brain metastases
This trial is for people with cancer that has spread to the brain (brain metastases). It tests a new approach where you start a systemic therapy (drugs that travel through your body) and later add focused radiation to the brain tumors, instead of treating them right away. The goal is to see if this sequence works well and avoids unnecessary side effects.
Houston, TexasAges 18 years+ - NCT06620380RecruitingPhase 2
Testing tumor samples to find the best drug for brain metastases
This trial tests tumor samples from brain metastases to see which drug might work best for you. It aims to guide your next treatment when standard options are limited.
BaselAges 18 years+ - NCT06541275Enrolling by invitation
Shrinking large brain aneurysms after treatment
This trial looks at how well large or giant brain aneurysms shrink over time after a minimally invasive procedure called endovascular intervention. It may help doctors understand which treatments lead to better long-term results.
AstanaAges 18 years+ - NCT03321370Recruiting
Study of brain swelling after severe head injury surgery
This trial looks at changes in brain activity after severe traumatic brain injury (TBI) when patients need emergency skull surgery. The goal is to better understand what happens in the brain after surgery and whether earlier recognition could help care after injury.
Minneapolis, MinnesotaAges 18 years+ - NCT06457906RecruitingPhase 3
Focused radiation vs whole brain radiation for up to 10 lung cancer brain spots
This trial compares two types of radiation for people with small cell lung cancer that has spread to the brain (10 or fewer spots). One approach uses focused radiation only on the tumors, the other treats the whole brain while trying to protect memory. The goal is to see which works better with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT06357377RecruitingPhase 1
NEO100 for children with high-grade brain tumors
This trial tests a new drug called NEO100 for children with certain types of brain tumors. It is given through a needle into the tumor or nearby fluid, and the study looks at safety and the right dose.
Orange, CaliforniaAges 5–18 - NCT06303869Recruiting
Deep brain stimulation for speech after stroke
This study tests if deep brain stimulation (a small device implanted in the brain) can improve speech and arm movement after a stroke that affected the deeper parts of the brain. It is designed for people who have trouble speaking clearly (dysarthria) from their stroke.
Pittsburgh, PennsylvaniaAges 18–75 - NCT06185686Recruiting
Brain Network Changes in Kids with Brain Tumors After Proton Radiation
This study looks at how proton radiation affects brain networks in children and teens with brain tumors. It uses MRI scans and computer tasks to understand changes in the brain during and after treatment.
St Louis, MissouriAges 8–21 - NCT06132685RecruitingPhase 2
Dexamethasone dosing after brain tumor surgery
This trial tests how to best use dexamethasone (a steroid) after brain tumor surgery to help recovery and reduce swelling. It looks at different dosing schedules for patients with common brain tumors.
Atlanta, GeorgiaAges 18 years+ - NCT06112067Recruiting
Brain implant for severe mental health conditions
This trial tests a brain implant called deep brain stimulation (DBS) for people with severe mental health conditions that have not improved with usual treatments. The goal is to see if it can reduce symptoms and improve quality of life.
ShanghaiAges 18–65 - NCT06121336Recruiting
Tracking a blood marker to measure stroke recovery
This study is looking at a protein in the blood called brain-derived tau, which may increase after a stroke. By measuring it over time, doctors hope to learn more about how the brain is healing and possibly predict recovery.
Munich, BavariaAges 18 years+ - NCT06095297Recruiting
Cognitive rehab for brain fog from long COVID
This study tests a computer-based cognitive training program combined with a gentle nerve stimulation device to see if it can improve brain fog and daily functioning in people with long COVID. If you're struggling with thinking, memory, or concentration after COVID, this might help.
Birmingham, AlabamaAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06072807RecruitingPhase 4
Brain imaging study for ER+ breast cancer with brain tumors
This trial tests a special PET scan called FES to see if it can detect estrogen receptors in brain metastases. It may help doctors better target treatment for people with ER+ breast cancer that has spread to the brain.
New York, New YorkAges 18 years+ - NCT06062888RecruitingPhase 2/Phase 3
Testing fresh frozen plasma for traumatic brain injury
This trial tests whether giving fresh frozen plasma (a blood product) soon after a traumatic brain injury can help people recover better. It is for adults aged 18 to 65 with moderate to severe TBI confirmed by CT scan.
Chicago, IllinoisAges 18–65 - NCT06024122Recruiting
Brain development after mild concussion in young children
This study looks at how a mild concussion affects brain development in young children (ages 3–5) compared to kids with other minor injuries like a broken arm. It involves one MRI scan and some simple check-ups to see how the brain heals over time.
RennesAges 3 years–5.9 years - NCT05480644Recruiting
Blood biomarker study for brain tumor patients
This study collects blood (and looks at samples) from adults who have a confirmed brain tumor, either one that started in the brain or one that spread to the brain. The goal is to understand biomarkers—signals in the body—that may help improve diagnosis or tracking over time.
Durham, North CarolinaAges 18 years+ - NCT05987644RecruitingPhase 1/Phase 2
Timing of brain radiation for ALK-positive lung cancer with brain mets
This trial tests whether it is better to delay brain radiation or give it right away in people with ALK-positive lung cancer that has spread to the brain and is causing few or no symptoms. If you are starting alectinib, you may be able to join and help find the best timing for radiation.
Stanford, CaliforniaAges 18 years+ - NCT05987592Recruiting
Wellness and brain education for migraine relief
This study tests an 8-week online program that combines brain education and wellness skills to help people with migraine. It aims to reduce headache-related disability and improve quality of life.
Cambridge, MassachusettsAges 18 years+ - NCT05942638Enrolling by invitation
Tracking how concussion affects college driving over time
This study follows young adults who drive to see how a concussion may affect driving abilities over time. You may be asked to complete driving- and health-related assessments, and the results could help improve safety and guidance after concussion.
Athens, GeorgiaAges 18 years+
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,017 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.