Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,170 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06341894RecruitingPhase 2
Dalpiciclib and hormone therapy for early breast cancer
This trial tests a new pill (dalpiciclib) combined with hormone therapy for women with early-stage, hormone receptor positive/HER2-negative breast cancer. The goal is to see if this combination can lower the chance of cancer coming back after surgery.
Nanjing, JiangsuAges 18–75 - NCT06404697RecruitingPhase 2
Extra radiation to lymph nodes above collarbone for high-risk breast cancer
This trial tests giving a focused, higher dose of radiation to the lymph nodes above the collarbone after breast cancer treatment. It is for patients whose cancer did not fully disappear from those nodes after pre-surgery chemotherapy, to see if extra radiation can help prevent recurrence.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07706556Recruiting
Remote activity program for breast cancer survivors
This trial tests a new program to help breast cancer survivors become more active. The program is delivered remotely using a smartphone app, and it adjusts based on your progress. It may be a good fit if you finished treatment less than 5 years ago and are not very active yet.
Lebanon, New HampshireAges 18 years+ - NCT06641544RecruitingPhase 4
Testing different drug combos for HER2-positive breast cancer
This trial tests different combinations of the drug Inetetamab as a first treatment for breast cancer that has spread and is HER2-positive. It aims to find which combo works best and is safe for newly diagnosed metastatic patients.
Shanwei, GuangdongAges 18–70 - NCT06639178Recruiting
Cream to prevent hand-foot syndrome from capecitabine in breast cancer
This trial tests whether a special cream containing N-acetylcysteine and urea can prevent the painful hand-foot syndrome often caused by the chemotherapy drug capecitabine. If you have breast cancer and are about to start capecitabine, this study may help reduce side effects.
Aviano, PordenoneAges 18 years+ - NCT06649565Recruiting
AI model to predict breast cancer treatment response
This trial uses an artificial intelligence model to predict how well breast cancer responds to neoadjuvant therapy (treatment before surgery). It aims to improve treatment planning by analyzing MRI scans taken before and after therapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07655934Recruiting
Lifestyle and energy in breast cancer survivors
This study looks at how lifestyle and energy levels affect women recently diagnosed with early-stage breast cancer. It may help researchers understand the body's changes during treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07587957Recruiting
Exercise and Brain Stimulation for Breast Cancer Survivors
This study tests whether combining exercise with a noninvasive brain-stimulation technique (tiny electrical pulses on the scalp) can help improve thinking and memory problems that some breast cancer survivors experience after treatment. Researchers want to see if this combination is practical and safe to use.
Boca Raton, FloridaAges 18 years+ - NCT07547423Recruiting
Ear laser acupuncture for better sleep in breast cancer patients
This study tests whether ear laser acupuncture (a painless light treatment on the ear) can help improve sleep in people with breast cancer who have insomnia. It is a non-drug approach that may be a safe alternative to sleeping pills.
TaichungAges 18–75 - NCT07542106Recruiting
Visual Biofeedback vs. Standard Therapy After Breast Cancer Surgery
This study compares a new visual biofeedback program (using real-time visual feedback to guide exercises) with standard physical therapy to help restore shoulder movement, strength, and function in women recovering from breast cancer surgery. The goal is to see which approach helps patients regain mobility and reduce pain more effectively.
Badajoz, BadajozAges 18 years+ - NCT04843865Recruiting
Chinese herbal add-on for joint pain from letrozole
This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.
Bukit Bintang, Kuala LumpurAges 18 years+ - NCT06155305Recruiting
Organoid drug test before breast cancer surgery
This trial uses a lab-grown mini-tumor (organoid) from your biopsy to test which chemotherapy drugs work best for your cancer before you have surgery. The goal is to personalize your treatment and improve outcomes.
Hangzhou, ZhejiangAges 18–70 - NCT07465497Enrolling by invitation
Preventing Chemo Brain with Prebiotics and Synbiotics
This trial tests whether taking a special blend of prebiotics and synbiotics (friendly bacteria and food for them) can help prevent or reduce memory and thinking problems that sometimes happen during chemotherapy for breast cancer.
Zapopan, JaliscoAges 18 years+ - NCT07471776RecruitingPhase 2
Predicting ADC treatment response with PET scans in advanced breast cancer
This study uses special PET scans to see if a type of targeted therapy called an anti-TROP2 ADC will work well for your advanced breast cancer. The therapy is already part of your standard care; the scans help doctors understand how your tumor responds.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07441733Recruiting
Using a green dye to map lymph nodes in breast cancer surgery
This trial tests if an injection of indocyanine green dye can help surgeons find and remove only the key lymph nodes in the armpit during breast cancer surgery. It aims to reduce the need for more extensive lymph node removal.
Peschiera del Garda, VeronaAges 18 years+ - NCT07427394RecruitingPhase 2
Camizestrant and atirmociclib for advanced breast cancer
This trial tests two experimental drugs—camizestrant and atirmociclib—for women with advanced ER-positive breast cancer that has worsened after prior treatment. The goal is to see if the combination is safe and tolerable.
St Louis, MissouriAges 18 years+ - NCT07432178RecruitingPhase 3
Targeted pill to skip chemo for high-risk breast cancer
This trial tests whether adding a targeted pill (dalpiciclib) to standard hormone therapy can safely replace chemotherapy for women with small, hormone-positive, high-risk breast cancers.
ShanghaiAges 18–70 - NCT07393425RecruitingPhase 2
Study of two targeted therapies before surgery for HER2+ breast cancer
This trial tests a combination of two drugs, trastuzumab deruxtecan (SHR-A1811) and pertuzumab, given before surgery to shrink HER2-positive breast cancer. It is for women with stage II or III breast cancer who have not yet had treatment and are in good overall health.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07380971Recruiting
Exercise program for breast cancer patients
This trial is testing a supervised exercise program designed for women with breast cancer. The goal is to see if it helps improve recovery and overall well-being during and after treatment.
Madrid, MadridAges 18 years+ - NCT07383818RecruitingPhase 2
Neoadjuvant therapy with trastuzumab rezetecan and toripalimab for HR+/HER2-low breast cancer
This trial tests a combination of two drugs (trastuzumab rezetecan and toripalimab) given before surgery to treat a specific type of breast cancer that is hormone-receptor-positive and HER2-low. It aims to see if this treatment can improve outcomes for patients who have not had prior cancer treatment.
HarbinAges 18–70 - NCT07386444Recruiting
Breathing exercises for breast cancer patients on chemo
This trial tests whether special breathing exercises can help breast cancer patients feel better during chemotherapy. You would do simple, guided breathing workouts to strengthen your breathing muscles.
Columbus, OhioAges 18 years+ - NCT07377279Recruiting
Acupuncture and compression to prevent nerve pain from chemo
This trial tests whether acupuncture and compression therapy can prevent nerve damage caused by taxane chemotherapy in early-stage breast cancer. It aims to reduce numbness, tingling, or pain in the hands and feet.
Guangzhou, GuangdongAges 18–70 - NCT06811870RecruitingPhase 1/Phase 2
Hyperbaric oxygen before surgery for breast cancer
This trial tests adding hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) before standard chemotherapy for breast cancer. The goal is to see if it helps shrink the tumor more effectively before surgery.
Guangzhou, GuangdongAges 18–60 - NCT07216495Recruiting
Exercise study for early-stage triple-negative breast cancer patients
This study tests if aerobic exercise can help women and men with stage 2 or 3 triple-negative breast cancer who are getting chemotherapy and immunotherapy before surgery. It aims to see if exercise improves treatment outcomes and quality of life.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,170 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.