Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,170 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06304857RecruitingPhase 3
Protecting the heart with dapagliflozin during breast cancer treatment
This trial tests if the diabetes drug dapagliflozin can protect the heart in people with breast cancer receiving a type of chemotherapy called anthracyclines. You may be able to join if you are between 18 and 80, have stage I-III breast cancer, and are about to start anthracycline treatment within the next 60 days.
Wroclaw, Lower Silesian VoivodeshipAges 18–80 - NCT07563621Recruiting
Understanding Vaginal Health Changes in Breast Cancer Survivors
This study examines vaginal dryness and discomfort—common side effects of breast cancer treatment—in women who've survived the disease. Researchers want to understand how often this happens and how much it affects daily life, which may help doctors better support survivors.
Hasselt, LimburgAges 18 years+ - NCT07490938Recruiting
Acupuncture for joint pain from breast cancer hormone therapy
This trial compares two types of acupuncture (electroacupuncture and ear acupressure) with standard care to see if they can help relieve joint pain caused by hormone therapy for breast cancer. It may be a good option if you have ongoing joint pain and are continuing hormone therapy.
Wuhan, HubeiAges 18–75 - NCT06830083Recruiting
Shorter radiation schedule after mastectomy with implant reconstruction
This trial is testing a shorter, higher-dose radiation schedule (hypofractionation) for women who have had a mastectomy and immediate breast reconstruction with implants. The goal is to see if this approach works as well as standard radiation while possibly being more convenient and causing fewer side effects.
Nanjing, JiangsuAges 18–65 - NCT06832904RecruitingPhase 2
Chemo plus two targeted drugs before surgery for HER2+ breast cancer
This trial tests whether giving a combination of two targeted drugs (pyrotinib and trastuzumab) along with standard chemotherapy before surgery can work better for HER2-positive breast cancer. It is for women whose cancer has not spread to distant organs and who have not yet had treatment for their cancer.
HangzhouAges 18–75 - NCT06828614Enrolling by invitation
Barriers to exercise in breast cancer patients
This study looks at the challenges women with breast cancer face when trying to exercise before, during, and after chemotherapy. It aims to understand what gets in the way so that better support can be offered.
ValenciaAges 18–65 - NCT06797531Recruiting
Ribociclib Real-World Study in Early Breast Cancer
This study observes people with early-stage hormone receptor positive, HER2-negative breast cancer who are taking ribociclib (Kisqali) with hormone therapy after surgery. It aims to see how well the treatment works and how safe it is in real life.
RiyadhAges 18–99 - NCT05933395RecruitingPhase 2
Targeted treatment for ER+ breast cancer after CDK4/6 therapy
This Phase 2 study tests a genetically guided treatment plan for ER-positive breast cancer that has progressed after CDK4/6 therapy. It may help by matching treatment to tumor genetic changes.
Lebanon, New HampshireAges 18 years+ - NCT05856773RecruitingPhase 3
Comparing two proton therapy schedules for breast cancer
This trial compares two ways of giving proton therapy to the breast or chest wall and nearby lymph nodes after surgery. The goal is to see if a shorter course of treatment works just as well as the standard longer course, while possibly reducing side effects.
Scottsdale, ArizonaAges 19 years+ - NCT06727487Recruiting
Ovarian suppression and exercise in young breast cancer patients
This trial tests whether adding a supervised exercise program helps women with hormone-positive breast cancer who are receiving ovarian suppression therapy. It looks at how exercise affects treatment side effects, quality of life, and long-term health.
MadridAges 18–45 - NCT06100263Recruiting
Breast cancer resilience exercise program for Black women
This study tests a personalized exercise program designed to help Black women build strength and resilience after breast cancer treatment. It aims to see if guided exercise can improve physical and emotional well-being.
Ann Arbor, MichiganAges 18 years+ - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT06977360Recruiting
Smartphone support for women with breast cancer on chemo
This study tests a new smartphone app designed to help women with breast cancer manage their chemotherapy treatment and its side effects. It aims to see if the app is easy to use and helpful for women going through chemo for the first time.
SingaporeAges 21–100 - NCT04158843Recruiting
Local surgery vs comfort treatment for limited breast cancer spread
This trial compares a more direct local treatment (targeting a small, limited spot) versus a comfort-focused palliative approach for breast cancer that has spread only to one side of the upper arm bone or breastbone area. It aims to see which approach works better while keeping side effects manageable.
Hangzhou, ZhejiangAges 18–75 - NCT05761470RecruitingPhase 2
Test before-surgery cancer treatment for breast tumors with DNA repair gene changes
This trial tests a combination of medications given before surgery (neoadjuvant therapy) for early breast cancer. It is designed for tumors with certain “DNA repair” gene mutations and aims to improve treatment results while shrinking or controlling the cancer.
Guangzhou, GuangdongAges 18–75 - NCT07743827Recruiting
Olanzapine-based steroid-sparing anti-nausea treatment for breast cancer
This trial tests a new anti-nausea medicine combination for breast cancer patients getting AC chemotherapy, specifically designed for those with diabetes, obesity, or other metabolic issues. It aims to reduce the need for steroids, which can be riskier for these patients.
Alexandria, Alexandria GovernorateAges 18–70 - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT06642948Recruiting
AI system for exercise rehab in breast cancer survivors
This study tests a new AI-based skeleton recognition system to guide rehabilitation exercises for breast cancer survivors. It may help reduce pain and improve mobility for those taking aromatase inhibitors.
ShanghaiAges Any age - NCT07469267Recruiting
Armpit radiation vs more surgery for early breast cancer with node spread
This trial tests whether radiation to the lower armpit (level I-II axilla) works as well as more extensive surgery for women with early-stage breast cancer that has spread to one or two sentinel lymph nodes (with cancer size > 2 mm). It aims to find a gentler treatment that still keeps the cancer from coming back.
Guiyang, GuizhouAges 18 years+ - NCT07244094Recruiting
AI predicts breast cancer spread risk from tissue scans
This trial uses artificial intelligence to analyze images of your tumor tissue to predict if breast cancer might spread to other parts of the body. It may help doctors better understand your individual risk and guide treatment decisions.
Changchun, JilinAges 18–95 - NCT07104266RecruitingPhase 2
Celecoxib for early triple-negative breast cancer
This research study tests whether adding a drug called celecoxib (an anti-inflammatory pill) can help treat early-stage triple-negative breast cancer after surgery, before or during radiation therapy. You may be eligible if your cancer was removed cleanly and you do not have other health issues like stomach ulcers, kidney problems, or a history of allergic reactions to certain pain relievers.
Sherbrooke, QuebecAges 18 years+ - NCT07071337RecruitingPhase 3
Study of SKB264 vs chemo for HR+/HER2- breast cancer after hormone therapy
This trial tests a new drug, SKB264, against standard chemotherapy for people with a common type of breast cancer (HR+/HER2-) that has spread and stopped responding to hormone therapy. It may offer a new option if you haven't had chemotherapy for advanced disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT06992882RecruitingPhase 3
Comparing two chemo regimens with Herceptin for early breast cancer
This trial tests if taking oral chemotherapy pills with trastuzumab (Herceptin) works as well as IV chemo (paclitaxel) with Herceptin after surgery for HER2-positive, lymph node-negative early breast cancer. It aims to find a more convenient treatment option.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06953882RecruitingPhase 2
Skipping chemo after surgery for ER+ HER2- breast cancer
This study tests whether some people with a certain type of breast cancer (ER-positive, HER2-negative) can safely skip chemotherapy. After surgery, they receive a targeted pill (ribociclib) plus hormone therapy instead. The goal is to see if this approach works just as well with fewer side effects.
New Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,170 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.