Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,170 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07352137Enrolling by invitation
Endoscopic Nipple-Sparing Mastectomy with Fat Grafting for Breast Reconstruction
This trial tests a new way to remove the breast through a small cut in the armpit (endoscopic nipple-sparing mastectomy) and immediately rebuild the breast using your own fat. It's for women with early-stage breast cancer who want to keep their nipple and have reconstruction at the same time.
Guanzhou, GuangdongAges 18–70 - NCT07109726RecruitingPhase 1/Phase 2
Testing TER-2013 for advanced tumors with AKT/PI3K/PTEN changes
This trial tests a new drug called TER-2013, alone or combined with another drug (fulvestrant), for people with advanced solid tumors that have specific genetic changes in the AKT/PI3K/PTEN pathway. It aims to see if the drug is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT04960839Recruiting
Preventive radiation to the other breast after breast cancer surgery
This study looks at whether “preventive” radiation to your other (opposite) breast can lower the chance of future breast cancer in people at higher genetic risk. You must have had surgery for early-stage breast cancer and agree to avoid removing the other breast and ovaries.
Jiangxi, JiangxiAges 30–70 - NCT07057791RecruitingPhase 2
Chemo plus immunotherapy for extensive-stage small cell lung cancer
This trial tests a combination of chemotherapy (platinum/etoposide) plus an immunotherapy drug (ivonescimab) for people with extensive-stage small cell lung cancer who have not received treatment before. The goal is to see if adding the immunotherapy improves outcomes.
Miami, FloridaAges 18 years+ - NCT07671937Recruiting
Sharing patient feedback in cancer care team meetings
This study gathers your feedback (like symptoms and quality of life) and shares it with your cancer care team during their group meetings, so they can better tailor your care. It is for people recently diagnosed with pancreatic, breast, or gynecologic cancer and aims to make sure your voice is heard in treatment decisions.
Birmingham, AlabamaAges 18 years+ - NCT07203729RecruitingPhase 2
A new drug for advanced breast cancer with severe symptoms
This trial tests a new drug called SHR-A1811 (a type of targeted therapy) for people with advanced breast cancer that is HER2-low and is causing severe symptoms (visceral crisis). The drug is given alone and aims to control the cancer and relieve symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT04480203Recruiting
Digital coping tools after new breast cancer diagnosis
This trial tests two online programs designed to help people cope after being diagnosed with breast cancer. It may help you manage stress and emotions during treatment or recovery.
OsloAges 20–69 - NCT05999149RecruitingPhase 3
Famitinib plus chemo and immunotherapy before breast cancer surgery
This trial tests whether adding a targeted therapy pill (famitinib) to standard chemo plus an immunotherapy (camrelizumab) can shrink triple negative breast cancer before surgery. It may help people with earlier-stage disease who have not had certain prior treatments.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07739511RecruitingPhase 1/Phase 2
Oral paclitaxel for HER2-positive breast cancer before surgery
This trial tests an oral form of paclitaxel combined with standard HER2 therapy given before surgery for HER2-positive breast cancer. It aims to find the best dose and see how well it works.
Guiyang, GuizhouAges 18–70 - NCT06387901Recruiting
Paclitaxel side effects in breast cancer: activity and body composition
This study looks at how physical activity and body composition affect the side effects of paclitaxel, a chemotherapy drug, in women with stage II or III breast cancer. It aims to help doctors understand who might have more or fewer side effects during treatment.
Brussels, JetteAges 18 years+ - NCT06711068Recruiting
Chemotherapy plus targeted therapy for HER2+ early breast cancer
This trial tests whether adding targeted therapy to chemotherapy after surgery can help prevent HER2-positive early breast cancer from coming back. It is for patients whose cancer has not spread to lymph nodes and who have certain tumor sizes and features.
Beijing, Beijing MunicipalityAges Any age - NCT07380646RecruitingPhase 2
Leucogen to prevent low white blood cells from ribociclib in early breast cancer
This trial tests if Leucogen can prevent neutropenia (low white blood cells) caused by ribociclib, a targeted therapy for hormone receptor-positive, HER2-negative early breast cancer. It may help you stay on treatment without delays or dose reductions.
Hangzhou, ZhejiangAges 18 years+ - NCT06846437RecruitingPhase 3
New drug JSKN003 vs. Kadcyla for HER2-positive advanced breast cancer
This trial compares a new targeted therapy (JSKN003) against Kadcyla (T-DM1) for people with HER2-positive breast cancer that has advanced or spread. Both drugs work by attaching a chemotherapy directly to HER2-positive cancer cells, and the study aims to see if the new drug works better or has fewer side effects.
ShanghaiAges 18 years+ - NCT06928701Recruiting
Diet and exercise for early breast cancer before surgery
This trial tests whether a personalized nutrition and exercise program can improve treatment response by changing how your body and immune system react to breast cancer before surgery. It is for women newly diagnosed with early-stage breast cancer who will receive neoadjuvant therapy (treatment before surgery).
Novara, NovaraAges 18 years+ - NCT07128030Recruiting
Moderate exercise for pain in breast cancer survivors
This study tests whether moderate exercise (like brisk walking) can help reduce pain and sensitivity in breast cancer survivors. It's designed for women who have finished their main treatments and still have discomfort in their arm or shoulder on the side where they had surgery.
MadridAges Any age - NCT04965064RecruitingPhase 2
Neratinib plus capecitabine for HER2-negative breast cancer brain mets
This study tests whether neratinib plus capecitabine can slow or shrink breast cancer that has spread to the brain. It is for people whose cancer shows an “overactive HER2 signal” on a specific tumor test, even though their cancer is labeled HER2-negative.
Rochester, New YorkAges 18 years+ - NCT04802759RecruitingPhase 1/Phase 2
Testing drug combinations for recurrent or advanced ER-positive breast cancer
This early-phase trial tests several combinations of cancer medicines to slow or control ER-positive breast cancer that has returned or progressed. It also checks safety and whether tumor or blood biomarkers can help match the right treatment to the right person.
Duarte, CaliforniaAges 18 years+ - NCT04332588RecruitingPhase 1
Testing PET/MRI monitoring for HER2-positive breast cancer before surgery
This early-phase study looks at how well PET/MRI scans can monitor treatment response in people with HER2-positive breast cancer before surgery. You may be asked to undergo specific scans during “neoadjuvant” therapy (treatment given before the main operation).
Birmingham, AlabamaAges 18 years+ - NCT04722341Recruiting
Time-limited eating for people with certain breast or rectal cancers
This study tests whether eating only within a shorter daily time window can improve cancer outcomes in people with specific breast or rectal cancers. It also looks at how this affects the body (such as metabolism) and who is most likely to benefit.
Birmingham, AlabamaAges 18 years+ - NCT07383441RecruitingPhase 3
Adding Biotherapy or Placebo to Standard Kidney Cancer Treatment
This trial tests whether adding a biotherapy (a special drug from a living source) or a placebo to standard treatments helps people with advanced kidney cancer. It may be a good option if your cancer hasn't been treated yet and you are in fairly good health.
Fayetteville, ArkansasAges 18 years+ - NCT05590949Recruiting
Bone health study for breast cancer survivors off bone medication
This study looks at bone complications in women who have finished treatment with denosumab (a bone-strengthening drug) and aromatase inhibitors (hormone therapy for breast cancer). It aims to learn more about what happens to bones after stopping these medications, which may help guide future care.
Basking Ridge, New JerseyAges 18 years+ - NCT06429696RecruitingPhase 2
Maintenance therapy for extensive stage small cell lung cancer
This study tests if a combination of an immunotherapy drug (PD-L1 inhibitor) and a targeted therapy pill (apatinib) can help keep extensive stage small cell lung cancer from growing after initial treatment. It is for people whose cancer was controlled with first-line chemo-immunotherapy.
Guangzhou, GuangdongAges 18–75 - NCT06347926Recruiting
Light therapy for menopause symptoms in breast cancer
This study tests a light-based treatment (photobiomodulation) to see if it improves sexual quality of life for women with breast cancer who have menopause-related vaginal symptoms that the usual moisturizers did not relieve.
Montpellier, HéraultAges 18 years+ - NCT04437160RecruitingPhase 2
Chemo after surgery for triple-negative breast cancer with leftover tumor
This Phase 2 study tests chemotherapy given after surgery for people with triple-negative breast cancer who still have cancer left after initial (neoadjuvant) chemo. It may help lower the chance the cancer comes back in people at higher risk based on leftover tumor and lymph node findings.
Beijing, Beijing MunicipalityAges 18–75
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,170 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.