Clinical trials
Breast Cancer Surgery clinical trials
Below are recruiting breast cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 1,162 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06711965Recruiting
Custom molds for breast reconstruction shaping
This trial tests custom 3D-printed molds to help shape breast tissue during reconstruction. It is for people who are already planning a DIEP or TRAM flap after mastectomy.
Houston, TexasAges 18 years+ - NCT04991025RecruitingPhase 2
Adding certolizumab to chemotherapy and nivolumab for lung cancer
This study tests whether adding an extra medication, certolizumab, to the usual chemotherapy and an immunotherapy drug called nivolumab can help people with early-stage lung cancer before they have surgery. It aims to see if this combination shrinks the cancer more and improves outcomes.
Basking Ridge, New JerseyAges 18 years+ - NCT04437160RecruitingPhase 2
Chemo after surgery for triple-negative breast cancer with leftover tumor
This Phase 2 study tests chemotherapy given after surgery for people with triple-negative breast cancer who still have cancer left after initial (neoadjuvant) chemo. It may help lower the chance the cancer comes back in people at higher risk based on leftover tumor and lymph node findings.
Beijing, Beijing MunicipalityAges 18–75 - NCT07739485RecruitingPhase 1/Phase 2
Oral paclitaxel before surgery for triple-negative breast cancer
This trial tests an oral form of a common chemo drug, paclitaxel, given before surgery for triple-negative breast cancer. It aims to find the best dose and see how well it shrinks tumors.
Guiyang, GuizhouAges 18–70 - NCT07666555RecruitingPhase 2
Culmerciclib rechallenge for HR+ HER2- breast cancer
This trial tests a new drug called Culmerciclib for women with advanced HR-positive, HER2-negative breast cancer that has stopped responding to a CDK4/6 inhibitor with hormone therapy. The goal is to see if giving this drug again can help when other treatments no longer work.
ShanghaiAges 18–75 - NCT07354022RecruitingPhase 3
Study of HRS-8080 with dalpiciclib for advanced breast cancer after hormone therapy fails
This trial tests a new combination of drugs (HRS-8080 and dalpiciclib) for women with advanced or metastatic breast cancer that has stopped responding to initial hormone therapy after surgery. It aims to see if this combination is safe and effective.
Beijing, Beijing MunicipalityAges 18–75 - NCT07034976Recruiting
Radiofrequency treatment for menopause symptoms in breast cancer survivors
This trial tests a non-surgical radiofrequency treatment, combined with pelvic floor exercises, to help with vaginal dryness and other menopause symptoms in breast cancer survivors. It may be an option if you are free of cancer and have bothersome vaginal dryness.
Madrid, MadridAges 18–75 - NCT05582538RecruitingPhase 2
Ceralasertib plus immunotherapy for advanced triple-negative breast cancer
This Phase 2 trial tests whether a drug called ceralasertib can help the immune system work better, followed by durvalumab plus nab-paclitaxel. It is for people with advanced triple-negative breast cancer whose cancer returned after earlier treatment, including chemotherapy and immune therapy.
Novara, NovaraAges 18 years+ - NCT04997993RecruitingPhase 1
Leflunomide for PTEN-altered or HER2-negative metastatic cancers
This Phase 1 trial studies whether leflunomide can slow or control advanced (metastatic) cancers in people whose tumors have specific PTEN changes or who have HER2-negative breast cancer. It’s primarily a safety-and-dosing study, but it may offer benefit if your cancer matches the tumor marker requirements.
New York, New YorkAges 18 years+ - NCT06839560RecruitingPhase 2
Immunotherapy plus chemotherapy and radiation for advanced breast cancer with brain metastases
This trial tests a combination of a PD-L1 inhibitor with a low-dose chemotherapy regimen and either immediate or delayed radiation therapy for people with HER2-negative breast cancer that has spread to the brain. The goal is to see if this approach helps shrink brain tumors and improve outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06176534RecruitingPhase 2
Comparing two treatments for advanced breast cancer with low hormone receptor
This trial compares two treatment options for advanced breast cancer that has low hormone receptor levels and is HER2-negative. It tests whether a combination of chemotherapy followed by maintenance therapy works better than a CDK4/6 inhibitor combined with hormone therapy. This is for people who have not had chemotherapy for their advanced disease.
Zhengzhou, HenanAges 18 years+ - NCT06611306Recruiting
Targeted whole-brain radiation for breast cancer that spread to the brain
This trial tests a newer, more targeted way to give whole-brain radiation for breast cancer that has spread to the brain. It aims to see if this approach can be as effective while causing fewer side effects compared to the standard whole-brain radiation.
London, LondonAges 16–100 - NCT06341621RecruitingPhase 3
Skipping chemo for ER+/HER2- breast cancer with 1–3 positive nodes
This trial tests whether skipping chemotherapy is safe for women with a specific type of early-stage breast cancer (ER-positive, HER2-negative) that has spread to 1–3 lymph nodes. Instead of chemo, you would receive a targeted pill called abemaciclib after standard hormone therapy.
ShanghaiAges 18–80 - NCT05460975Recruiting
Study of dense breast tissue seen on ultrasound
This study looks at breast cancer risk by analyzing what is seen in dense breast tissue during a screening ultrasound. It may help improve how doctors evaluate risk in people with very dense breasts.
SeoulAges 40–69 - NCT07520760RecruitingPhase 2
Eribulin Plus Anlotinib for HER2-Negative Breast Cancer
This trial tests a combination of two cancer drugs (eribulin and anlotinib) for women whose breast cancer has spread and stopped responding to previous treatments, particularly antibody-drug conjugates. The study aims to see if this combination can help slow or shrink the cancer.
GuangzhouAges 18 years+ - NCT07331363Recruiting
Robot ultrasound for breast cancer screening
This trial tests whether using a robot to perform breast ultrasound can help find cancer early. You would use a smartphone to guide the screening, and the study compares this method to standard screening.
Xiantao, HubeiAges 35–64 - NCT07263451Recruiting
Testing a new treatment for small, early breast cancers
This study tests if a new treatment called IRE (irreversible electroporation) can safely treat small, early-stage breast cancers. It's for people with a single, small tumor that has not been treated yet.
Hangzhou, ZhejiangAges 18 years+ - NCT06533332RecruitingPhase 1
Testing ERX-315 for advanced solid tumors
This trial tests a new drug called ERX-315 for people with advanced solid tumors (like breast, ovarian, pancreatic, endometrial, or liver cancer) that have not responded to standard treatments. The goal is to see if the drug is safe and how well it works.
Ryde, New South WalesAges 18 years+ - NCT06415266Recruiting
Sexual quality of life in breast cancer with onco-sexology support
This trial tests whether offering onco-sexology support proactively (right away) or on-request helps improve sexual quality of life for people finishing breast cancer treatment. If you've recently completed surgery, radiation, or chemotherapy (or started targeted therapies within the last 3 months), you may be able to join.
Saint-Herblain, Saint HerblainAges 18 years+ - NCT06884852Recruiting
Preventing pain after mastectomy: nerve block vs. epidural
This study compares two methods to prevent long-term pain after breast cancer surgery: a nerve block using ultrasound guidance or an epidural. The goal is to see which helps women feel less pain months after their mastectomy.
CairoAges 18–65 - NCT07743190RecruitingPhase 2
Lighter chemo for early-stage triple-negative breast cancer with high immune cells
This trial tests a less intense chemotherapy regimen (without one of the standard drugs) combined with immunotherapy for people with early-stage triple-negative breast cancer whose tumors have a high level of immune cells (TILs). The goal is to see if this approach is effective while reducing side effects.
Syracuse, New YorkAges 18 years+ - NCT05879926RecruitingPhase 3
Testing chemo after hormone therapy in premenopausal early breast cancer
This Phase 3 trial checks whether adding chemotherapy after standard hormone-blocking treatment works better for some premenopausal women with early-stage, ER-positive, HER2-negative breast cancer. It targets patients with limited lymph node spread and a lower-to-intermediate tumor “recurrence” risk score.
Birmingham, AlabamaAges 18–60 - NCT05872295RecruitingPhase 1
Study drug for HER2-positive advanced cancers
This Phase 1 trial tests IKS014 to see how safe it is and how well it works in advanced solid tumors that have HER2. You may be eligible if your tumor is HER2-positive (including certain “low HER2” types) and your body’s blood counts and organ function are strong enough.
Newport Beach, CaliforniaAges 18 years+ - NCT07782814Recruiting
A study of a new breast scan for breast tissue evaluation
This study tests a new, non-invasive scanning tool that uses harmless electrical signals to look at breast tissue. It may help doctors evaluate breast conditions without surgery, which could be useful for diagnosis or monitoring treatment.
LondonAges 18–85
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Common questions
- Are there clinical trials for breast cancer surgery?
- Yes. Clin2 currently lists 1,162 recruiting breast cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.