Clinical trials · California
Cancer clinical trials in California
We’re tracking 1,320 recruiting cancer studies with a site in California — including Early Phase 1, Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06327685RecruitingPhase 1
Avapritinib and Decitabine for SM-AHN
This trial tests a combination of two drugs, avapritinib and decitabine, for people with systemic mastocytosis plus another blood cancer (SM-AHN). The goal is to see if the combination works better than either drug alone.
Palo Alto, CaliforniaAges 18 years+ - NCT06336928Recruiting
Blood test validation for breast cancer diagnosis
This study is testing a new blood test (liquid biopsy) to see if it can accurately detect breast cancer or track remission. If you are a woman getting a mammogram, have an abnormal finding, were recently diagnosed, or are in remission after treatment, you may be able to join and help validate this test.
Los Angeles, CaliforniaAges 18 years+ - NCT06311214RecruitingPhase 2
Personalized ADC therapy for advanced solid tumors
This trial tests personalized antibody-drug conjugates (ADCs) for advanced solid tumors. It looks for specific proteins on your tumor cells to match you with a treatment that targets them directly.
Encinitas, CaliforniaAges 18 years+ - NCT06317649RecruitingPhase 2
Venetoclax with hypomethylating agents for older or unfit adults with FLT3-mutated AML
This trial tests a combination of medicines (venetoclax and a hypomethylating agent) for people with acute myeloid leukemia (AML) who have a FLT3 mutation. It may be an option for older adults or those who cannot tolerate intensive chemotherapy.
Berkeley, CaliforniaAges 18 years+ - NCT06312176RecruitingPhase 3
Study of new drugs for HR+/HER2- advanced breast cancer
This trial tests two new drugs (sacituzumab tirumotecan and pembrolizumab) against standard treatments for a type of advanced breast cancer that is hormone receptor positive and HER2 negative. It's for people whose cancer has worsened despite hormone therapy with a CDK4/6 inhibitor.
Fullerton, CaliforniaAges 18 years+ - NCT06271291Recruiting
Pancreatic Cancer Detection Study for High-Risk People
This study looks for people at high risk for pancreatic cancer, either because of family history, certain genetic mutations, or concerning pancreatic cysts. Researchers want to follow you over time to find cancer early, when it's easier to treat.
San Francisco, CaliforniaAges 18 years+ - NCT06252753Recruiting
Observational study of durvalumab for liver and bile duct cancer
This study looks at how well durvalumab (Imfinzi) works for people with liver or bile duct cancer. It follows your treatment as part of regular care to gather more information.
Coronado, CaliforniaAges 18–130 - NCT06257693RecruitingPhase 1
Prostate cancer implant trial before prostate removal surgery
This trial tests a new enzalutamide implant (Enolen) placed in the prostate before surgery to see if it helps treat early prostate cancer. It is for men who are already planning to have their prostate removed.
Fresno, CaliforniaAges 21 years+ - NCT06266299RecruitingPhase 1
Study of KK2269 for adults with solid tumors
This trial tests a new drug called KK2269 for adults with solid tumors that have spread or cannot be removed by surgery. It aims to see if the drug is safe and effective, possibly as a treatment option for certain cancers like lung or stomach cancer.
Duarte, CaliforniaAges 18 years+ - NCT06221800Recruiting
Gut bacteria and lung cancer treatment side effects study
This study looks at how the bacteria in your gut (microbiome) might affect how well your lung cancer treatment works and what side effects you experience. The goal is to learn if certain gut bacteria can predict treatment response or side effects for people with advanced non-small cell lung cancer.
Orange, CaliforniaAges 18 years+ - NCT06228482RecruitingPhase 1
Targeted radioactive therapy for advanced lung cancer
This trial tests a new targeted radioactive drug that seeks out a specific marker on lung cancer cells. It first uses a low-dose imaging scan to see if the cancer cells have this marker, then gives a higher-dose treatment to destroy those cells.
Sacramento, CaliforniaAges 18 years+ - NCT06207032Recruiting
Cancer biobank registry study
This study collects blood samples and health information from people diagnosed with cancer to build a research database. It may help future patients by enabling better understanding and treatment of cancer.
Whittier, CaliforniaAges 18–99 - NCT06216301RecruitingPhase 3
Electric fields with immunotherapy and chemo for advanced lung cancer
This trial tests adding a device that delivers electric fields (Tumor Treating Fields) to standard immunotherapy and chemotherapy for people with advanced non-small cell lung cancer that has not been treated before. It may help slow tumor growth.
Fullerton, CaliforniaAges 18 years+ - NCT06183437RecruitingPhase 4
Can I stop heart meds after cancer therapy?
This trial tests whether it is safe to stop taking heart failure medications in people who developed heart weakness after cancer treatment but whose heart function has since recovered. It aims to see if stopping these drugs leads to any worsening of heart health.
Los Angeles, CaliforniaAges 18 years+ - NCT06196008Recruiting
Exercise coaching for older adults having lung cancer surgery and their caregivers
This study tests if a telephone-based physical activity coach helps older adults (65+) recover better after lung cancer surgery compared to self-monitored activity. Caregivers can also join to learn how to support their loved one and improve their own well-being.
Davis, CaliforniaAges 18 years+ - NCT06172296RecruitingPhase 3
Dinutuximab plus transplant for high-risk neuroblastoma
This trial tests adding a targeted drug called dinutuximab to standard chemotherapy, surgery, and a stem cell transplant for children and young adults with a new diagnosis of high-risk neuroblastoma. The goal is to see if this combination helps more patients stay in remission.
Downey, CaliforniaAges Up to 30 years - NCT06136624RecruitingPhase 3
Comparing a new drug to standard hormone therapy for advanced prostate cancer
This trial tests a new pill, opevesostat, against other hormone treatments for men with metastatic castration-resistant prostate cancer that has progressed after previous therapies. It aims to see which approach works better.
Orange, CaliforniaAges 18 years+ - NCT06124157RecruitingPhase 2
Targeted therapy plus chemo for children with Ph+ or Ph-like B-ALL
This trial tests if adding a targeted drug (dasatinib or imatinib) to a chemotherapy combination with blinatumomab works better for children and young adults with a specific genetic form of B-cell acute lymphoblastic leukemia. The goal is to see if this approach can improve treatment outcomes for patients with Philadelphia chromosome-positive or ABL-class Ph-like B-ALL.
Downey, CaliforniaAges 1 year–46 years - NCT06126276RecruitingPhase 2
Testing neratinib with or without palbociclib for HER2+ solid tumors
This trial tests two targeted drugs—neratinib alone or with palbociclib—for people with HER2-positive solid tumors (other than breast cancer) that have returned or not gone away. The goal is to see if blocking HER2 and CDK4/6 can shrink or slow the tumor.
Encinitas, CaliforniaAges 18 years+ - NCT06119581RecruitingPhase 3
Oloromosib with Immunotherapy as First Treatment for KRAS G12C Lung Cancer
This trial tests a new targeted pill (olomorasib) combined with immunotherapy (pembrolizumab) and possibly chemotherapy for people with advanced non-small cell lung cancer that has a KRAS G12C mutation and has not been treated before.
Los Angeles, CaliforniaAges 18 years+ - NCT06123286RecruitingEarly Phase 1
Tart cherry and omega-3s for joint pain from hormone therapy
This study tests whether taking tart cherry and omega-3 supplements can help reduce joint pain and stiffness caused by aromatase inhibitors (a common breast cancer treatment). If you have bothersome joint pain while on this hormone therapy, you may be able to join.
Torrance, CaliforniaAges 18 years+ - NCT06121180RecruitingPhase 2
Cemiplimab plus ziv-aflibercept for metastatic uveal melanoma
This trial tests two drugs, cemiplimab and ziv-aflibercept, together for people whose uveal melanoma has spread. It may be an option if previous treatments have stopped working or you haven't had treatment yet.
Los Angeles, CaliforniaAges 18 years+ - NCT05866302Recruiting
CT breathing-scan test to detect chronic lung injury after transplant
This study uses a special way to analyze breathing-related CT images to find early or ongoing lung injury after an allogeneic stem cell transplant. It may help clinicians recognize chronic lung complications sooner and better guide care.
Stanford, CaliforniaAges 3 years+ - NCT05890352RecruitingPhase 2
Add new medicines to standard treatment for returning lymphoma
This Phase 2 study tests whether adding tafasitamab, lenalidomide, tazemetostat, and zanubrutinib (along with standard lymphoma treatment) can improve outcomes in people whose large B-cell lymphoma has returned or not responded. It may help control disease more effectively and improve response duration for eligible patients.
Lancaster, CaliforniaAges 18 years+
Cancer trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting cancer studies listed above.
- Cedars-Sinai Medical Center · 6 studies
- City of Hope · 5 studies
- Kaiser Permanente-Oakland · 3 studies
- UCSF Medical Center · 3 studies
- University of California, Davis · 3 studies
- Children's Hospital Los Angeles · 2 studies
- Children's Hospital of Orange County · 2 studies
- City of Hope at Irvine Lennar · 2 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in California?
- Yes. We're currently tracking 1,320 recruiting cancer studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.