Clinical trials · Illinois
Cancer clinical trials in Illinois
We’re tracking 676 recruiting cancer studies with a site in Illinois — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Illinois
- NCT06121180RecruitingPhase 2
Cemiplimab plus ziv-aflibercept for metastatic uveal melanoma
This trial tests two drugs, cemiplimab and ziv-aflibercept, together for people whose uveal melanoma has spread. It may be an option if previous treatments have stopped working or you haven't had treatment yet.
Chicago, IllinoisAges 18 years+ - NCT06171269Recruiting
MRI-guided radiation dose reduction for prostate cancer
This trial tests whether using MRI scans to guide radiation can allow lower doses to the healthy parts of the prostate, potentially reducing side effects. It is for men with intermediate- or high-risk prostate cancer that can be seen on MRI and has not spread.
Chicago, IllinoisAges 18 years+ - NCT06196008Recruiting
Exercise coaching for older adults having lung cancer surgery and their caregivers
This study tests if a telephone-based physical activity coach helps older adults (65+) recover better after lung cancer surgery compared to self-monitored activity. Caregivers can also join to learn how to support their loved one and improve their own well-being.
Evanston, IllinoisAges 18 years+ - NCT06207032Recruiting
Cancer biobank registry study
This study collects blood samples and health information from people diagnosed with cancer to build a research database. It may help future patients by enabling better understanding and treatment of cancer.
O'Fallon, IllinoisAges 18–99 - NCT06216301RecruitingPhase 3
Electric fields with immunotherapy and chemo for advanced lung cancer
This trial tests adding a device that delivers electric fields (Tumor Treating Fields) to standard immunotherapy and chemotherapy for people with advanced non-small cell lung cancer that has not been treated before. It may help slow tumor growth.
Zion, IllinoisAges 18 years+ - NCT06230185Recruiting
Blood test to monitor treatment response in triple-negative breast cancer
This trial is testing whether a blood test can track how well chemotherapy is working in people with early-stage triple-negative breast cancer. You would provide blood samples before and during treatment, and the results may help your doctor understand your response better.
Peoria, IllinoisAges 18 years+ - NCT06262516Recruiting
Lymph node removal during kidney/ureter cancer surgery
This study looks at whether removing nearby lymph nodes during standard kidney/ureter removal surgery helps people with upper tract urothelial carcinoma. You will be placed into one of two groups – one gets the usual surgery alone, the other gets surgery plus lymph node removal.
Springfield, IllinoisAges 19 years+ - NCT06271291Recruiting
Pancreatic Cancer Detection Study for High-Risk People
This study looks for people at high risk for pancreatic cancer, either because of family history, certain genetic mutations, or concerning pancreatic cysts. Researchers want to follow you over time to find cancer early, when it's easier to treat.
Peoria, IllinoisAges 18 years+ - NCT06310759Recruiting
Testing urine DNA for bladder cancer detection
This trial looks at whether a large urine sample can detect bladder cancer DNA. It may help diagnose cancer without needing a cystoscopy. You can join if you are about to have a cystoscopy to check for bladder cancer.
Chicago, IllinoisAges 18–100 - NCT06311214RecruitingPhase 2
Personalized ADC therapy for advanced solid tumors
This trial tests personalized antibody-drug conjugates (ADCs) for advanced solid tumors. It looks for specific proteins on your tumor cells to match you with a treatment that targets them directly.
Chicago, IllinoisAges 18 years+ - NCT06312176RecruitingPhase 3
Study of new drugs for HR+/HER2- advanced breast cancer
This trial tests two new drugs (sacituzumab tirumotecan and pembrolizumab) against standard treatments for a type of advanced breast cancer that is hormone receptor positive and HER2 negative. It's for people whose cancer has worsened despite hormone therapy with a CDK4/6 inhibitor.
Chicago, IllinoisAges 18 years+ - NCT06413680RecruitingPhase 1/Phase 2
Study of REGN10597 with or without cemiplimab for advanced solid tumors
This study tests a new drug called REGN10597, either alone or with cemiplimab, for people with advanced solid tumors (like melanoma or kidney cancer) that have not responded to standard treatments. The goal is to see if the combination can shrink tumors or slow their growth.
Chicago, IllinoisAges 18 years+ - NCT06418204Recruiting
Cannabis use study for cancer patients in community clinics
This study looks at the benefits and risks of using cannabis or cannabinoids for cancer patients. It aims to help understand how these products affect symptoms and quality of life during chemotherapy or immunotherapy.
Crystal Lake, IllinoisAges 18 years+ - NCT06426628Recruiting
Nasal swab test for lung nodule risk
This trial tests a new nasal swab test to help doctors better understand your risk if you have a small lung nodule. The test looks at cells from your nose to give more information about whether the nodule might be cancer, without needing a biopsy right away.
Peoria, IllinoisAges 29–85 - NCT06504914Recruiting
A lifestyle program for Black female breast cancer survivors
This study tests a lifestyle program designed for Black women who have survived breast cancer. It aims to help with high blood pressure or weight management by teaching healthy cooking and habits.
Chicago, IllinoisAges 18–99 - NCT06525220RecruitingPhase 3
New drug combo vs. standard for head and neck cancer
This trial tests a new combination of two immunotherapy drugs (petosemtamab plus pembrolizumab) compared to pembrolizumab alone for people with head and neck cancer that has spread or come back and cannot be cured locally. It may be an option if your cancer has a certain protein (PD-L1) and you haven't had prior cancer treatment for this stage.
Chicago, IllinoisAges 18 years+ - NCT06532877Recruiting
Telephone support for advanced GI cancer and caregivers
This study offers telephone-based support for people with advanced gastrointestinal cancer who are experiencing fatigue, and for their family caregivers. It aims to help both you and your caregiver manage the challenges of cancer care together.
Chicago, IllinoisAges 18 years+ - NCT06561685RecruitingPhase 1
Study of LY4050784 for Advanced Solid Tumors with SMARCA4 Changes
This trial tests a new drug, LY4050784, for people with advanced solid tumors that have a specific change in a gene called SMARCA4 (BRG1). The study aims to see if the drug is safe and effective. It may be an option for those who have tried other treatments or have no standard options left.
New Lenox, IllinoisAges 18 years+ - NCT06567743RecruitingPhase 2
Study of a new virus therapy for high-risk bladder cancer
This trial tests a new virus-based medicine, cretostimogene grenadenorepvec, given directly into the bladder for people with high-risk non-muscle-invasive bladder cancer. It may help prevent the cancer from coming back, especially for those who have not had BCG treatment or whose cancer did not respond to BCG.
Glenview, IllinoisAges 18 years+ - NCT06589310Recruiting
Blood test for early cancer detection study
This study tests a blood test that looks for signs of cancer early in people without symptoms. It aims to see how well the test works in real-world settings.
Evanston, IllinoisAges 50–80 - NCT06655246RecruitingPhase 1
Ziftomenib and imatinib for advanced GIST
This trial tests a new drug, ziftomenib, combined with imatinib for people with advanced or spreading gastrointestinal stromal tumors (GIST) that have a KIT mutation. It may help if your GIST has gotten worse while on imatinib.
Chicago, IllinoisAges 18 years+ - NCT06671613Recruiting
Fasting-mimicking diet with immunotherapy for advanced lung cancer
This study combines a special periodic diet that mimics fasting with the standard immunotherapy drug pembrolizumab (Keytruda) for people with advanced non-small cell lung cancer. The goal is to see if the diet can help the immunotherapy work better.
Chicago, IllinoisAges 18 years+ - NCT06705803Recruiting
Prostate cancer ablation registry study
This study collects information from men with prostate cancer who are having or have had a procedure to destroy prostate tumors (ablation). It aims to track outcomes over time to improve future treatments.
Hyde Park, IllinoisAges 22 years+ - NCT06385080RecruitingPhase 1/Phase 2
Study of amivantamab for head and neck cancer
This trial tests a drug called amivantamab, either alone or with other treatments, for people with head and neck cancer that has spread or come back. The goal is to see if the drug can help shrink tumors or control the cancer.
Chicago, IllinoisAges 18 years+
Cancer trials by city in Illinois
Where these studies are running in Illinois
Institutions with a site for the recruiting cancer studies listed above.
- University of Chicago · 6 studies
- Northwestern University · 4 studies
- Illinois CancerCare-Peoria · 3 studies
- Jesse Brown VA Medical Center · 2 studies
- OSF Saint Francis Medical Center · 2 studies
- Southern Illinois University School of Medicine · 2 studies
- Advocate Christ Medical Center
- Advocate Condell Medical Center
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in Illinois?
- Yes. We're currently tracking 676 recruiting cancer studies with a site in Illinois, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in Illinois?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Illinois to take part?
- Not necessarily. These studies have a site in Illinois, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in Illinois regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.