Clinical trials
Chemotherapy clinical trials
Below are recruiting chemotherapy clinical trials, each written for real people, not researchers. We’re tracking 1,994 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05914389RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for colon cancer
This Phase 2 trial studies giving chemotherapy plus immune therapy before surgery for certain colon cancers that do not have mismatch repair defects (MSS/pMMR). The goal is to shrink and control the tumor and improve outcomes compared with standard approaches.
Hangzhou, ZhejiangAges 18–75 - NCT05916755Recruiting
Testing tumor clues that predict response to immunotherapy
This study looks for “biomarkers,” or tumor clues, that may help predict who benefits from checkpoint inhibitor immunotherapy in triple-negative breast cancer. It may help doctors choose the right treatment approach in the future, especially when chemotherapy is planned.
BarcelonaAges 18 years+ - NCT05921253RecruitingEarly Phase 1
Check a brain-heart device to reduce chemo heart risk
This early-phase study tests a “neuromodulation” device (stimulating nerves that may affect the heart and blood vessels) to help lower cardiovascular risks after certain cancer chemotherapy. It may be most relevant if you recently had an anthracycline-based treatment and also have other heart-risk factors.
Oklahoma City, OklahomaAges 18–99 - NCT05928429Recruiting
Cold treatment to prevent nerve pain from weekly paclitaxel
This trial tests whether cryotherapy (cooling the hands/feet during chemo) can prevent or lessen nerve pain caused by paclitaxel in people with early breast cancer. It may help you stay more comfortable and function better during treatment.
CopenhagenAges 18 years+ - NCT05930665RecruitingPhase 2
Immunotherapy plus chemo for unresectable pleural mesothelioma
This trial tests whether adding cadonilimab (an immune treatment) and bevacizumab (a medicine that targets blood supply to tumors) to standard chemotherapy can control pleural malignant mesothelioma that cannot be removed with surgery. It’s meant for people who have not yet started medicine for advanced disease and who meet health and blood test requirements.
Guangzhou, GuangdongAges 18 years+ - NCT05937477Recruiting
AI tool study to predict chemotherapy side effects and symptoms
This study tests an artificial-intelligence (AI) tool in a phone app that helps predict side effects and symptoms from chemotherapy. It may help patients and their care team plan and respond to side effects more effectively.
Seoul, GangnamguAges 20 years+ - NCT05939661RecruitingPhase 2
Total treatment before surgery for early rectal cancer
This Phase 2 study tests a “total neoadjuvant” approach, meaning you receive cancer treatment before surgery, to improve safety and effectiveness for rectal cancer. It may help by shrinking the tumor and planning a more effective operation, while researchers carefully track side effects.
OsakaAges 18 years+ - NCT05945745Recruiting
Molecular testing and treatment options for small cell lung cancer
This trial is for adults with small cell lung cancer where your diagnosis is confirmed by a tissue test. The study looks at molecular (tumor-level) features to help guide treatment choices that may fit you better.
ShanghaiAges 18 years+ - NCT05947838Recruiting
Blood test helps choose chemotherapy before colorectal or appendix surgery
This study uses a blood test called ctDNA to help tailor (personalize) neoadjuvant chemotherapy for people with colorectal or appendix cancer before surgery. The goal is to see if using ctDNA can help doctors pick the most appropriate chemotherapy plan for you.
Houston, TexasAges 18 years+ - NCT05949606RecruitingPhase 1/Phase 2
New study for advanced lung cancer using two antibody drugs
This Phase 1/2 trial tests whether two antibody drugs (SI-B001 and SI-B003) work well for locally advanced or metastatic non-small cell lung cancer, sometimes together with chemotherapy. It may help shrink tumors and control the disease, while closely monitoring safety and side effects.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05965531RecruitingPhase 2
TAS-102 plus radiation before surgery for rectal cancer
This trial studies whether adding TAS-102 (a chemotherapy medicine) to radiation given before treatment improves outcomes for certain locally advanced rectal cancers. It may help by trying to shrink the tumor before the next steps of care.
Guangzhou, GuangdongAges 18–70 - NCT05968677Recruiting
Amino acids and flavonoids to reduce chemotherapy side effects
This trial tests whether a specific nutrition supplement (amino acids and flavonoids) can lessen chemotherapy side effects, support nutrition, and improve quality of life in people with non-metastatic breast cancer. It focuses on women who are receiving certain chemotherapy medicines and can eat by mouth and attend regular visits.
PaviaAges 50–70 - NCT05976815Recruiting
Exercise added to chemotherapy before breast cancer surgery
This study tests whether adding a supervised physical exercise program around the time of “before-surgery” chemotherapy helps people with newly diagnosed breast cancer. You may be assigned to an exercise group or a usual-care group, and the researchers will compare outcomes between them.
Vila Nova de Gaia, Porto DistrictAges 18 years+ - NCT05977673RecruitingPhase 2
Tislelizumab for untreated Hodgkin lymphoma when chemo isn’t suitable
This Phase 2 trial tests tislelizumab (an immune therapy) in people with newly diagnosed classical Hodgkin lymphoma who cannot safely get standard chemotherapy. It aims to see how well the treatment works and whether it is safe for older adults and others with health limits.
Alessandria, ITAges 65 years+ - NCT05978193RecruitingPhase 2
Radiation plus chemo-immunotherapy for advanced esophageal cancer
This trial tests whether adding radiation to a combination of chemotherapy and immunotherapy can help people with stage IV esophageal cancer that has spread. It is for those who haven't had any prior treatment for their cancer.
ShanghaiAges 18 years+ - NCT05978648RecruitingPhase 2
Trilaciclib for early-stage HR-negative breast cancer after surgery
This trial tests if adding trilaciclib to standard chemotherapy after surgery can help people with hormone receptor-negative breast cancer. It aims to reduce side effects and improve treatment outcomes.
Guangzhou, GangdongAges 18 years+ - NCT05983276RecruitingPhase 2
Combination therapy for drug-resistant ovarian cancer
This trial tests a new two-drug combination (decitabine and selinexor) given with standard chemotherapy to see if it can reverse drug resistance in ovarian cancer that has come back or worsened after treatment.
Maywood, IllinoisAges 18 years+ - NCT05983783RecruitingPhase 3
Testing two drug combinations for advanced prostate cancer
This trial compares two combinations of drugs for men with metastatic hormone-sensitive prostate cancer that has a high tumor burden. One group gets rezvilutamide plus hormone therapy and chemotherapy, while the other gets rezvilutamide plus hormone therapy alone. The goal is to see which is more effective and safe.
Nanjing, JiangsuAges 40–80 - NCT05984342RecruitingPhase 1
Tislelizumab plus chemo after surgery for lymph node-positive esophageal cancer
This trial tests whether adding the immunotherapy drug tislelizumab to standard chemotherapy after surgery can help prevent esophageal cancer from coming back. It is for people whose cancer had spread to lymph nodes at the time of surgery.
Shantou, GuangdongAges 18–70 - NCT05988814RecruitingPhase 2
FOLFIRINOX3 for advanced pancreatic cancer
This trial tests a stronger version of FOLFIRINOX chemotherapy for people with pancreatic cancer that cannot be removed by surgery or has spread to other parts of the body. It aims to see if the new dosing schedule works better and is safe.
DijonAges 18 years+ - NCT05990426Recruiting
Alternate day fasting during chemo for gynecologic cancers
This trial tests whether alternating between a fasting day and a normal eating day can help people recovering from gynecologic cancer surgery while they receive chemotherapy. It aims to see if this eating pattern is safe and helpful during treatment.
Chicago, IllinoisAges 18 years+ - NCT06001151RecruitingPhase 2
Cadonilimab plus chemo for PD-L1 negative lung cancer
This trial tests a new immunotherapy drug called cadonilimab combined with chemotherapy as a first treatment for people with advanced non-squamous non-small cell lung cancer that does not have the PD-L1 protein. The goal is to see if this combination works better than standard treatments.
Wuhan, HubeiAges 18–75 - NCT06006650RecruitingPhase 2
Neoadjuvant therapy for stage II-IVA esophageal cancer
This trial tests a treatment given before surgery for patients with a type of esophageal cancer called squamous cell carcinoma, stages II to IVA. The goal is to see if this approach can improve outcomes.
Xi'an, ShaanxiAges 18–75 - NCT06008106RecruitingPhase 3
Tunlametinib pill vs chemo for advanced NRAS melanoma
This trial tests a new pill called Tunlametinib (a MEK inhibitor) compared to standard chemotherapy for people with advanced melanoma that has a specific NRAS gene change and no longer responds to immunotherapy. It aims to see if the new pill works better or is safer than chemo.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for chemotherapy?
- Yes. Clin2 currently lists 1,994 recruiting chemotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chemotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chemotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.