Clinical trials
Chronic Disease clinical trials
Below are recruiting chronic disease clinical trials, each written for real people, not researchers. We’re tracking 1,247 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05519475RecruitingPhase 2
Gene-silencing medicine trial for adults with MASH and liver scarring
This Phase 2 study tests a gene-silencing treatment to improve chronic liver disease called MASH, especially in people with certain genetic risk. You may be eligible if you have MASH with moderate-to-advanced scarring and specific test results, and if other liver causes and recent substance/alcohol issues don’t apply.
Chandler, ArizonaAges 18–75 - NCT05465044Recruiting
Twice-weekly dialysis for veterans starting kidney treatment
This study compares starting hemodialysis two times per week versus three times per week for veterans in their first year of dialysis. It aims to see if a less frequent schedule can be just as safe and effective for those who still make urine.
Long Beach, CaliforniaAges 18 years+ - NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+ - NCT05273424Enrolling by invitation
Study of outcomes for people on long-term dialysis
This study looks at health outcomes for people living with chronic kidney disease who have been on hemodialysis for more than 90 days. It may help doctors better understand what to expect over time and how dialysis care can be improved in Brazil.
Pelotas, Rio Grande do SulAges 18 years+ - NCT05161078Enrolling by invitation
Studies CARPEDIEM care for newborns and babies in participating hospitals
This trial looks at how to improve outcomes for newborns and infants who receive CARPEDIEM as part of routine hospital care. It aims to see whether an interdisciplinary team approach can make treatment safer and more effective.
Palo Alto, CaliforniaAges Any age - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+ - NCT05106387Recruiting
Study follow-up for people who had a kidney transplant
This study follows adults who previously received vonsetamig in an earlier study and then got a kidney transplant while enrolled. It mainly looks at what happens after the transplant and helps doctors understand outcomes over time.
Los Angeles, CaliforniaAges 18–70 - NCT05095714Recruiting
Fast MRI for close monitoring of high-risk liver cancer
This trial studies a faster MRI scan to help track early liver cancer in people who have cirrhosis and are considered high risk. It may improve how often and how well doctors can look for changes without using longer imaging sessions.
BondyAges 18 years+ - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT04626167RecruitingEarly Phase 1
Testing a bladder transplant done with a kidney transplant
This early-phase study is testing a combined bladder and kidney transplant approach for people whose bladder problems damage the kidneys. The goal is to see if this treatment can improve bladder and kidney outcomes and be done safely.
Rochester, MinnesotaAges 1–60 - NCT04592640RecruitingEarly Phase 1
Amniotic stem cell treatment for calciphylaxis
This early-phase study tests a stem cell therapy made from amniotic (placenta) tissue for people with calciphylaxis. If you qualify, the goal is to see whether this treatment is safe and potentially helpful for this rare, painful condition.
Nanjing, JiangsuAges 18–75 - NCT04522765Recruiting
Tracking daily blood pressure patterns in people at high heart risk
This study measures how your blood pressure changes across the day in people at higher risk of heart and blood vessel disease. It may help researchers understand why blood pressure patterns vary, which could guide better prevention or care.
EdinburghAges 18–90 - NCT04487314Recruiting
Study of chronic vein disease over time
This study follows people (and certain close family members) to document how chronic vein problems develop and change over time. You would get yearly checkups and ultrasound scans to track the natural course of the condition.
Saint Petersburg, Sankt-PeterburgAges 10 years+ - NCT03979534Recruiting
Protecting Kidneys With a Low-Protein Diet
This study tests whether a step-by-step low-protein diet can help protect your kidneys if you have advanced chronic kidney disease (stages 4 or 5) or stage 3 that is getting worse quickly. The goal is to see if this diet approach can slow down kidney damage.
La FlècheAges 18 years+ - NCT03524222Recruiting
Home hospital care for adults after sudden illness
This trial tests whether certain adults can safely receive hospital-level care at home instead of staying in the hospital, using a home care team. It may help you recover in your own home if your condition fits their plan and you have support at home.
Boston, MassachusettsAges 18 years+ - NCT02132741Recruiting
Eye imaging study in people with kidney disease
This study uses a painless eye scan to learn more about how kidney disease may be linked to eye changes. It may help improve understanding and future care for people with chronic kidney disease and/or high blood pressure.
Edinburgh, MidlothianAges 18–80 - NCT01644903Recruiting
Checking biomarkers after a liver transplant
This study follows people who are getting a liver transplant (including repeat transplants) to monitor changes in their body using test results. It may help doctors understand how patients are doing after transplant and improve care over time.
Chicago, IllinoisAges 18 years+ - NCT01016613Enrolling by invitation
Kidney health study that helps build a tissue and data bank
This study collects health information and biological samples to better understand kidney disease and support future kidney research. It may help your care indirectly by improving how kidney conditions are recognized and studied.
Ann Arbor, MichiganAges Any age - NCT05553223Recruiting
Very small activity doses for COPD symptoms
This study tests whether “micro-doses” of physical activity (short, small amounts) can help people with COPD. It aims to see if these small activity bursts are safe and beneficial for people who have stable COPD.
Kelowna, British ColumbiaAges Any age - NCT07270575Recruiting
Resorbable stents for leg artery disease with limb threat
This trial tests a special scaffold that slowly releases medicine to open blocked arteries below the knee. It is for people whose leg pain or wounds are severe enough to threaten the limb.
HullAges 18 years+ - NCT06701968Recruiting
Healthy Nordic diet for heart artery health after heart attack
This study tests whether a healthy Nordic diet (like whole grains, berries, fish, and vegetables) can slow down hardening of the arteries in people who have had a heart attack or have stable chest pain. It lasts 18 months and aims to improve heart health.
UppsalaAges 50–80 - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT03568630Recruiting
Blood tests to study early pancreatic cancer risk
This study looks at blood “markers” to find early signs or higher risk for pancreatic cancer. You may join if you have certain risk factors (like new diabetes, pancreatic cysts/pancreatitis, or a strong family history) and can come to Omaha for blood draws twice a year.
Omaha, NebraskaAges 19 years+ - NCT03388476Enrolling by invitation
Breathing carbon dioxide measurement to detect lung high blood pressure
This trial tests whether measuring carbon dioxide you breathe out can help detect pulmonary hypertension earlier. It may help doctors spot this lung blood vessel condition sooner, especially around the time you get a heart test.
Giessen, HesseAges 18 years+
Hear when a new Chronic Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic disease?
- Yes. Clin2 currently lists 1,247 recruiting chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.