Clinical trials
Chronic Musculoskeletal Pain clinical trials
Below are recruiting chronic musculoskeletal pain clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07827677Recruiting
Brain stimulation for muscle pain relief in people with insomnia
This study looks at whether different types of brain stimulation (called TMS) can help reduce the muscle pain triggered during a test. It is designed for people who also have insomnia, and who are otherwise healthy.
Hong KongAges 18–60 - NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT07049029Recruiting
Physical activity and pain resilience study for teens
This study tests if physical activity can help teenagers with chronic pain feel better and be more active. It may help you learn ways to manage pain.
Columbus, OhioAges 12–17 - NCT05555576Recruiting
Vitamin C to reduce opioid use after an ER visit
This trial tests whether taking vitamin C after an emergency room visit for a new, short-term muscle or joint pain can lower how many opioid pain pills you use. It may help by reducing opioid consumption while you recover.
Montreal, QuebecAges 18 years+ - NCT03705598Recruiting
Tai chi for older adults with chronic pain
This study tests whether practicing Tai Chi can reduce pain and improve balance in older adults who have chronic pain in multiple areas. Tai Chi is a gentle form of exercise that involves slow movements and breathing, and it may help you feel better and reduce your risk of falling.
Boston, MassachusettsAges 65 years+ - NCT06491121Recruiting
Can high-intensity training with a smartphone help chronic back pain?
This trial tests if a technology-supported high-intensity exercise program can help adults with chronic low back pain. You'll use your own smartphone to help guide the training and attend regular therapy sessions.
Wilrijk, AntwerpenAges 18–65 - NCT06471920Recruiting
Telerehab for chronic low back pain in rural areas
This study tests whether a video-based physical therapy program can help people with chronic low back pain who live in rural areas. If you qualify, you'll get telerehabilitation (rehab done at home through video calls) to reduce pain and improve function.
Baltimore, MarylandAges 18 years+ - NCT04046562Recruiting
Testing a teen pain-and-weight program
This trial studies a program meant to help teens manage weight when they also have ongoing muscle or joint pain. It may help by targeting pain feelings and supporting healthier weight habits at the same time.
Hartford, ConnecticutAges 12–18 - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT06671860Recruiting
Exercises and hands-on therapy for neck pain
This study tests whether combining eye exercises with hands-on therapy helps people with non-specific neck pain (pain not caused by a known injury or disease). It may help improve how your neck moves and reduce discomfort.
IstanbulAges 18–65 - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT06398847Recruiting
Virtual reality self-hypnosis for HIV-related pain
This study tests if using a virtual reality (VR) headset for self-hypnosis can help people with HIV manage chronic pain. You would practice at home with a smartphone app, and researchers will track your pain levels over time.
New York, New YorkAges 18 years+ - NCT07645859Recruiting
High-Intensity vs. Moderate Exercise for Chronic Lower Back Pain
This trial compares two types of exercise programs—one with short, intense bursts of activity and one with steady, moderate activity—to see which works better for people with long-lasting lower back pain that has no clear medical cause. You would participate in supervised exercise sessions over several weeks.
KarachiAges 20–48 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT07544108Recruiting
Understanding What Affects Neck Pain Recovery
This study helps researchers understand which patients with long-term neck pain recover better and why. By learning more about your neck pain and how it affects your daily life, the study may help doctors predict outcomes and improve treatment.
Kütahya, KütahyaAges 18–65 - NCT06957639Enrolling by invitation
Physiotherapy for chronic neck pain
This trial tests a physiotherapy program for people with neck pain lasting 3 months or longer. The goal is to see if it helps reduce pain and improve daily function.
Yozgat, YozgatAges 18–64 - NCT05689788Recruiting
High-intensity laser treatment for chronic neck pain
This trial tests whether high-intensity laser therapy can reduce long-lasting neck pain and improve daily function. It may help people whose neck pain has lasted at least 3 months and who meet specific pain and disability scores.
Santiago, Las CondesAges 18 years+ - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT06212349Recruiting
Physiotherapy for pain and quality of life in endometriosis
This trial tests a combined therapy and education program for women with endometriosis. It aims to reduce pelvic pain, improve muscle function, and enhance quality of life. If you have persistent pelvic pain and certain muscle issues, this study may help.
ValenciaAges 18–45 - NCT07393503Enrolling by invitationPhase 4
Pain relief for new muscle and joint injuries
This trial compares two common treatments for new muscle or joint pain: an over-the-counter pain reliever (Tylenol and ibuprofen) versus an oral steroid (a stronger anti-inflammatory medication). The goal is to see which option works better for short-term pain and recovery.
Buffalo, New YorkAges 18 years+ - NCT07826650Recruiting
How acute pain affects sleep in people with insomnia
This study looks at how a short-term (acute) pain affects sleep quality in people who suffer from insomnia compared to healthy sleepers. Participation may help researchers understand the link between pain and sleep problems.
Hong KongAges 18–60 - NCT07245303Recruiting
How Light Affects Pain in Chronic Pain
This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT07555873Recruiting
Osteopathic treatment versus physical therapy for neck and head dysfunction
This study compares two hands-on treatment approaches—osteopathic manipulation and physiotherapy—for chronic neck pain, headaches, and dizziness caused by cervical dysfunction. If you qualify, you'll receive one of these treatments and help researchers understand which works better.
Pristina, PejtonAges 18–65
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Common questions
- Are there clinical trials for chronic musculoskeletal pain?
- Yes. Clin2 currently lists 112 recruiting chronic musculoskeletal pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic musculoskeletal pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic musculoskeletal pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.