Chronic Musculoskeletal Pain clinical trials

Mobile program to reduce pain and improve health in older adults

This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.

Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls

Physiotherapy for pain and quality of life in endometriosis

This trial tests a combined therapy and education program for women with endometriosis. It aims to reduce pelvic pain, improve muscle function, and enhance quality of life. If you have persistent pelvic pain and certain muscle issues, this study may help.

How back pain affects thinking in older adults

This study looks at how chronic low back pain might affect memory, attention, and other thinking skills in adults aged 60 to 85. You will complete questionnaires, thinking tasks, and a brain scan to help researchers understand the link between pain and cognitive function.

Low-level laser therapy for chronic jaw pain

This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.

Study of a new cannabinoid for long-term body pain

This Phase 2 study tests how a new cannabinoid product affects people with ongoing musculoskeletal pain (like arthritis or injuries). It’s meant to see whether the product can improve pain for eligible adults who are not already using CBD regularly.

Pain relief for new muscle and joint injuries

This trial compares two common treatments for new muscle or joint pain: an over-the-counter pain reliever (Tylenol and ibuprofen) versus an oral steroid (a stronger anti-inflammatory medication). The goal is to see which option works better for short-term pain and recovery.

Desk Work, Stress, and Muscle Pain With or Without Migraine

This study looks at how office work, job stress, and muscle tension relate to migraines and neck/shoulder pain in desk workers. Researchers want to understand if certain body changes (called central sensitization) connect these issues, which could lead to better ways to help office workers feel better.

How Light Affects Pain in Chronic Pain

This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.

Chinese herbal add-on for joint pain from letrozole

This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.

Psilocybin-assisted treatment for long-term body pain

This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.

Psilocybin therapy to help you taper opioid pain medicine

This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.

Strength training volume for women with fibromyalgia

This study tests whether different amounts of strength training (resistance exercise) help women with fibromyalgia feel better. It compares three different workout volumes to see which one women prefer and which works best for their symptoms.

Chronic pain study in severe hemophilia A

This study looks at chronic pain in people with severe hemophilia A. It aims to understand pain better through questionnaires and joint health checks.

Osteopathic treatment versus physical therapy for neck and head dysfunction

This study compares two hands-on treatment approaches—osteopathic manipulation and physiotherapy—for chronic neck pain, headaches, and dizziness caused by cervical dysfunction. If you qualify, you'll receive one of these treatments and help researchers understand which works better.

Dry needling for long-lasting lower back muscle pain

This study tests whether dry needling (thin needles placed into specific muscles) can reduce moderate, long-lasting lower back pain. It focuses on people who have pain from trigger points in a specific back muscle, rather than pain caused by other medical problems.

Back pain's effect on thinking in older adults

This study looks at how long-term lower back pain affects thinking skills like memory and attention in adults aged 60 to 85. Participants must speak Cantonese, be right-handed, and have normal thinking abilities. The study uses email or text for some tasks.

Powered leg braces to help people move more easily

This study tests modular powered leg braces (orthoses) to improve voluntary movement and walking ability in adult participants. It may help you learn whether the braces are safe and useful for your kind of mobility and daily movement.

Baduanjin exercise for chronic low back pain in office workers

This trial tests whether an eight-week Baduanjin exercise program can reduce chronic low back pain and improve daily function in office workers. Baduanjin is a gentle mind-body practice that involves slow movements and breathing, and it may help relieve pain caused by prolonged sitting.

Back exercises for female university students with back pain

This study tests two different types of back exercises to see which works better for reducing mechanical low back pain (pain not caused by injury or disease) in female university students. It may help you find a good exercise routine if you have had this type of back pain for a while.

Comparing topical diclofenac to oral ibuprofen for pain from ankle or knee injuries in children

This study compares a topical gel (diclofenac) applied directly to the injury site versus an oral medication (ibuprofen) taken by mouth to see which works better for treating pain from ankle or knee injuries in children. It may offer a way to relieve pain without a pill.

Digital physical therapy for musculoskeletal pain

This trial studies a smartphone/tablet-based care program to help people with neck, back, shoulder, elbow, wrist/hand, hip, knee, or ankle pain. It may help reduce pain and improve function using guided exercises, as long as it is safe for you to do light-to-moderate activity.

Muscles, nerves, and period pain in women

This study looks at how your muscles and nervous system relate to period pain. It compares women with and without painful periods to understand why some have more pain.

Neck Pain Treatment Using Pressure Feedback for Teachers

This study tests whether using pressure feedback (a device that gives you information about muscle tension) while doing neck exercises helps reduce neck pain in teachers. Researchers want to see if this technique strengthens deep neck muscles and improves your symptoms.