Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07784504Recruiting
Physical therapy for chronic neck pain
This study tests different physical therapy approaches to improve pain and quality of life in people with long-lasting neck pain that hasn't fully improved with prior therapy. Participants must be 18-65, have had neck pain for over 3 months, and still have at least moderate pain and disability.
Istanbul, BeykozAges 18–65 - NCT06918535Recruiting
Relaxation vs muscle technique for neck pain in computer users
This study compares two therapies for neck pain in people who use computers for long hours. The goal is to see which method better reduces pain and stiffness from tight neck muscles.
Karachi, SindhAges 20–45 - NCT06175884Recruiting
Communication skills for chronic muscle and joint pain
This trial tests how a physical therapist's communication style affects pain and function in people with long-term muscle or joint pain. Participants will fill out questionnaires and watch a video to see if better communication improves outcomes.
LamiaAges 18–65 - NCT06386224Recruiting
Online pain self-management for pancreatitis pain
This study tests an online pain-management program for adults with chronic or recurrent acute pancreatitis. The program is done on your own device (or a loaner iPad) and is designed to help you learn skills to cope with pain and improve daily life.
Seattle, WashingtonAges 18 years+ - NCT06161805RecruitingPhase 3
Esketamine for chronic pain from endometriosis
This trial tests if esketamine, a nasal spray, can reduce chronic pelvic pain in women with endometriosis that hasn't improved with standard painkillers. You may qualify if you have severe pain and are scheduled for endometriosis surgery.
DelftAges 18–50 - NCT07018375RecruitingPhase 4
Oliceridine for pain after lung surgery
This study tests a new pain medication called oliceridine given through an IV after lung surgery to see if it helps reduce long-term pain. Participation may help improve pain management after surgery.
Baoding, HebeiAges 18–75 - NCT06870162Recruiting
Pain disengagement training: a writing study for chronic pain
This study tests a writing-based program to help people with chronic pain learn to disengage from pain-related thoughts. It aims to reduce pain catastrophizing and improve daily function.
Boston, MassachusettsAges 18 years+ - NCT06775535Recruiting
Spinal cord stimulation trial for chronic pain
This trial tests a closed-loop spinal cord stimulator that adjusts stimulation based on nerve signals. It may help people with chronic pain who are already scheduled to try this type of device.
RoeselareAges 18 years+ - NCT07791966Recruiting
Brain stimulation for chronic pain
This study tests a non-invasive brain stimulation technique to help people with chronic pain, specifically Complex Regional Pain Syndrome (CRPS), manage pain-related avoidance behaviors. It may help reduce pain and improve daily function.
Cleveland, OhioAges 18 years+ - NCT04787848Recruiting
Testing pain causes and treatments in people with HIV
This study looks at why chronic widespread pain happens in people with HIV and tests new ways to understand and treat it. You may be able to join if your HIV is stable on treatment and you meet pain and safety requirements.
Miami, FloridaAges 19–65 - NCT06910644Recruiting
Pain relief after mastectomy: dexmedetomidine vs lidocaine
This trial tests whether adding dexmedetomidine or lidocaine to anesthesia during mastectomy helps reduce long-term pain after surgery. It's for women with breast cancer undergoing mastectomy with lymph node removal.
CairoAges 18–75 - NCT06082206Recruiting
Nerve blocks to prevent long-term pain after breast cancer surgery
This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) to see which one better prevents long-term pain after breast cancer surgery.
AsyutAges 20–65 - NCT07125027Recruiting
Exercise and mindfulness for sciatica pain
This study tests a program called Move-MORE that combines exercise and mindfulness to help people with nerve-related leg pain (sciatica) that has lasted at least 3 months. You would use the program at home, attend weekly video sessions for 8 weeks, and complete questionnaires and daily surveys to see if the program improves your pain and quality of life.
Portland, OregonAges 18–75 - NCT07248813Recruiting
Home-based rehab program for chronic low back pain
This trial tests a telerehabilitation program you can do from home using a smartphone or computer. It aims to improve function and reduce pain for people with chronic low back pain compared to usual care.
México, TexcocoAges 18–60 - NCT06944730Recruiting
Trunk muscle training for better movement and balance in low back pain
This study tests whether trunk muscle training can improve the quality of your movements and balance if you have chronic low back pain. It is designed for people with moderate pain and no other major health issues.
Hong KongAges 18–55 - NCT07589790Recruiting
Virtual Reality and Mindfulness for Chronic Low Back Pain
This study tests whether virtual reality combined with mindfulness-based cognitive therapy can help reduce chronic low back pain lasting 3+ months. The trial aims to see if this newer approach eases pain and improves quality of life.
Suzhou, JiangsuAges 20–70 - NCT07491354Recruiting
Predicting chronic pain after ICU trauma
This study looks at how biological, psychological, and social factors might help predict long-term pain after a traumatic injury that required ICU care. If you are an adult with a serious injury and at least one broken bone, you may be eligible.
MontpellierAges 18 years+ - NCT07057232Recruiting
Chronic insomnia treatment for non-cancer pain patients
This study is testing a treatment for chronic insomnia (trouble sleeping) in people who have long-term pain from non-cancer causes. Researchers want to see if improving sleep can help you manage your pain better.
Badalona, CataloniaAges 18 years+ - NCT07302958Recruiting
Comparing remote, in-person, and mixed exercise for neck pain
This trial compares three ways to treat chronic neck pain: doing exercises at home with remote guidance, doing them in a clinic with a therapist, or a mix of both. It aims to find which method works best for people with ongoing neck pain.
CairoAges 20–45 - NCT06814808Enrolling by invitation
Comparing three treatments for chronic neck pain
This study compares three different treatments for chronic neck pain caused by trigger points (tender knots in muscles). It aims to find which approach works best for pain relief and improved function.
Istanbul, ZeytinburnuAges 18–65 - NCT05922007Recruiting
Study of chronic pain effects on daily life
This study looks at how long-lasting pain and its treatment affect quality of life and physical activity. It asks people to complete questionnaires to understand what changes over time.
Ostrava, Moravian-Silesian RegionAges 18–65 - NCT06778460Recruiting
Esketamine and lidocaine for pain after liver surgery
This trial tests whether two medicines, esketamine and lidocaine, can reduce long-term pain after liver surgery and possibly improve survival. It is for people who are having a planned liver removal (hepatectomy).
Chengdu, SichuanAges 18–75 - NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+ - NCT06373978RecruitingPhase 4
Non-narcotic pain relief after elbow needle procedure
This study tests non-narcotic pain medicine after a needle procedure for chronic elbow tendon pain. It compares different pain-relief options to find what works best without opioids.
Coral Springs, FloridaAges 18–65
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.