Chronic pain clinical trials

Brain stimulation for nerve pain relief

This trial tests if mild magnetic pulses to the brain area controlling movement can safely reduce nerve pain from damaged peripheral nerves.

Study of back muscle tissue and treatment for low back pain

This study looks at the tissue in your lower back using ultrasound and physical exams. It tests a treatment to see if it helps people with new or long-term low back pain, and also compares results to people without pain.

Pain Reprocessing Therapy (PRT) in a Specialist Pain Clinic: A Feasibility Study

Oxycodone plus pregabalin for long-term pain after spinal surgery

This trial studies whether taking oxycodone together with pregabalin (both pain medicines) can reduce chronic pain that can linger after spinal surgery. If you qualify, you may be asked to rate your pain and complete questionnaires during recovery.

Osteopathic treatment for chronic low back pain in veterans

This trial tests whether adding osteopathic manipulative treatment (OMT) to standard VA care helps reduce chronic low back pain. OMT involves a healthcare provider using their hands to move and stretch muscles and joints.

Group Music Therapy for Chronic Pain Management in Active Duty Service Members

Quiet focus: mindfulness for pain and depression

This study compares two programs—mindfulness-based therapy and a general health program—to see which better helps older Black adults manage long-term pain and mild depression. It aims to find new ways to improve well-being.

AI and brain scans for chronic pain in rheumatoid arthritis

This study uses AI, brain scans, and blood tests to understand chronic pain in rheumatoid arthritis (RA). It may help find better ways to treat pain in the future.

Test removing mesh versus leaving it for groin pain

This study compares removing the pre-surgery mesh versus not removing it in people who have long-lasting groin pain after inguinal hernia repair. It may help doctors learn which approach best reduces ongoing pain.

Jincaopian tablets for ongoing pelvic pain after pelvic infection

This trial tests whether Jincaopian tablets can reduce long-lasting pelvic pain that happened after pelvic inflammatory disease. You may be able to join if your pain is still moderate to severe and other causes of pelvic pain have been ruled out.

Remote physical therapy for chronic pelvic pain from endometriosis

This trial tests if a physical therapy program done at home through video calls can help reduce chronic pelvic pain in people with endometriosis. If you have ongoing pelvic pain and have already had medical or surgical treatment, this study may offer a new way to manage your pain.

Cognitive functional therapy for chronic shoulder pain

This trial tests a new approach called cognitive functional therapy for people with long-term shoulder pain. It combines mental strategies with gentle movements to help you manage pain and improve function.

How chronic pain patients make decisions about treatment

This study looks at what helps people with chronic pain make choices about their treatment. You will be asked some questions during your first pain clinic visit to see how your decision-making relates to how well treatments work.

Ozone therapy for pelvic pain after gynecological cancer treatment

This study is looking at whether ozone therapy can help relieve chronic pelvic pain caused by gynecological cancer treatments like radiation and chemotherapy. It aims to understand how the treatment works at a molecular level.

Pain education and goal setting for chronic low back pain

This trial tests whether learning about pain and setting your own exercise goals helps people with long-term low back pain become more active. You will receive online sessions and support to safely increase your physical activity.

Cupping vs Massage Tool for Chronic Low Back Pain

This trial tests two hands-on therapies—dry cupping and a special massage technique—to see which works better for long-term low back pain caused by muscle knots. You may be able to join if your pain has lasted over 3 months and you have trigger points.

Perioperative dexmedetomidine for chronic pain after lung surgery

This study tests whether giving the medication dexmedetomidine during and after surgery can prevent long-term pain after a thoracoscopic lung resection. If you are scheduled for this type of lung surgery, you may be able to join and help see if this drug makes recovery less painful over time.

Registry for artery embolization to treat chronic pain

This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.

Pelvic floor muscle function and endometriosis pain study

This study looks at how pelvic floor muscles work in women with endometriosis-related pelvic pain compared to healthy women. It aims to understand if muscle function is linked to pain, which could help improve treatments.

Nerve freezing for rib-fracture pain using ultrasound guidance

This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.

Study ways to evaluate lumbar back pain blocks

This study looks at how well different methods can evaluate a common procedure used for chronic low back pain (lumbar medial branch blocks). If you have long-lasting, everyday back pain and are having this procedure, you may help researchers compare evaluation approaches.

Predicting pain after planned surgery

This study looks at whether we can predict how much pain you will feel after surgery. It aims to help doctors better manage pain after your operation.

Test whether new spinal cord stimulation settings improve chronic pain

This trial studies whether changing the “stimulation pattern” of spinal cord stimulation can reduce long-lasting pain and improve daily function. You might be a good candidate if you have chronic trunk or leg pain and have already tried multiple pain treatments without enough relief.

Pain acceptance training for emotional and physical distress

This trial tests a training program to help people accept chronic pain and emotional distress. It looks at how thinking patterns might help or hinder progress.