Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT07559890Recruiting
Nerve ablation for low back pain with Modic changes
This study tests a procedure that uses heat to stop a nerve in the lower back from sending pain signals. It may help people with long-term central low back pain who have not gotten better with other treatments and have Modic changes on MRI.
PragueAges 18 years+ - NCT07411859Recruiting
Reboot Pain: Brain stimulation for chronic pain
This trial uses a gentle brain stimulation technique called tDCS to see if it can reduce chronic pain in people with certain pain conditions. You would self-administer the treatment and report your results.
Atlanta, GeorgiaAges 18–89 - NCT07049029Recruiting
Physical activity and pain resilience study for teens
This study tests if physical activity can help teenagers with chronic pain feel better and be more active. It may help you learn ways to manage pain.
Columbus, OhioAges 12–17 - NCT06968689Recruiting
Brain activity study for experimental and chronic pain
This study uses MRI and EEG to look at brain connections involved in pain. It may help us understand how the brain processes pain and could lead to better treatments.
Houston, TexasAges 18–60 - NCT06847360Recruiting
Home-based ear stimulation for IBS pain
This trial tests a gentle, non-invasive ear stimulation device (taVNS) used at home to reduce pain from Irritable Bowel Syndrome (IBS). It might help if you have moderate pain most days.
New Haven, ConnecticutAges 18–29 - NCT06585033Recruiting
Spinal cord stimulation for pain after back surgery
This trial tests how much of the pain relief from spinal cord stimulation is due to the placebo effect. It is for people with ongoing leg pain after back surgery who have already tried other treatments without success.
ArnhemAges 18–70 - NCT03705598Recruiting
Tai chi for older adults with chronic pain
This study tests whether practicing Tai Chi can reduce pain and improve balance in older adults who have chronic pain in multiple areas. Tai Chi is a gentle form of exercise that involves slow movements and breathing, and it may help you feel better and reduce your risk of falling.
Boston, MassachusettsAges 65 years+ - NCT07342777Recruiting
Exercise for Pain Relief in Multiple Sclerosis
This study tests whether exercise can help reduce pain in people with multiple sclerosis. If you have MS and moderate to severe pain, you may be asked to participate in a supervised exercise program.
Aarhus, DenmarkAges 18 years+ - NCT06472349Recruiting
Upper trapezius muscle and chronic shoulder pain study
This study looks at how the upper trapezius muscle works and how it may be linked to long-term shoulder pain. Researchers will measure muscle shape, activity, and how you move your shoulder to understand pain better.
TaipeiAges 18–50 - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT06491121Recruiting
Can high-intensity training with a smartphone help chronic back pain?
This trial tests if a technology-supported high-intensity exercise program can help adults with chronic low back pain. You'll use your own smartphone to help guide the training and attend regular therapy sessions.
Wilrijk, AntwerpenAges 18–65 - NCT06471920Recruiting
Telerehab for chronic low back pain in rural areas
This study tests whether a video-based physical therapy program can help people with chronic low back pain who live in rural areas. If you qualify, you'll get telerehabilitation (rehab done at home through video calls) to reduce pain and improve function.
Baltimore, MarylandAges 18 years+ - NCT07636967Recruiting
Ankle Muscle Strength in Chronic Low Back Pain
This study measures the strength and function of ankle muscles in people with chronic low back pain lasting over 3 months. Understanding how ankle muscles work may help explain why some people develop long-term low back pain.
Tanta, Gharbia GovernorateAges 20–25 - NCT07724704Recruiting
Exercise comparison for long-term low back pain
This study compares two sets of exercises (called McGill and Sahrmann) to see which is better at reducing chronic low back pain. If you have had non-specific low back pain for more than 12 weeks, this trial may help you strengthen your core and feel better without surgery or medication.
Lahore, Punjab ProvinceAges 20–50 - NCT07551323Recruiting
Myofascial Release vs. Pilates for Chronic Low Back Pain
This study compares two hands-on treatment approaches—myofascial release (deep tissue massage) and Pilates exercises—to see which works better for chronic low back pain that isn't caused by nerve damage. If you have persistent lower-back pain, this trial might help you find relief through one of these therapies.
Istanbul, IstanbulAges 18–45 - NCT06908200Recruiting
Radiofrequency for chronic pelvic pain with myofascial syndrome
This trial compares radiofrequency treatment, myofascial therapy, and no treatment to see which is most effective for women with chronic pelvic pain caused by tight or tender pelvic floor muscles. It aims to help reduce pain and improve quality of life.
BarcelonaAges 18 years+ - NCT07543835Recruiting
Yoga and Yoga Nidra for Chronic Low Back Pain
This study compares two types of yoga practices—traditional yoga and a deep relaxation technique called Yoga Nidra—to see which works best for chronic low back pain. You'll attend sessions over several weeks and track how your pain changes.
Orlando, FloridaAges 18–65 - NCT07494162Recruiting
Acupuncture for chronic low back pain with muscle knots
This trial tests if acupuncture can help chronic low back pain by looking at changes in muscle metabolism and blood flow. It compares real acupuncture with a sham (fake) procedure to see if there is a true benefit.
Sacramento, CaliforniaAges 18 years+ - NCT04046562Recruiting
Testing a teen pain-and-weight program
This trial studies a program meant to help teens manage weight when they also have ongoing muscle or joint pain. It may help by targeting pain feelings and supporting healthier weight habits at the same time.
Hartford, ConnecticutAges 12–18 - NCT05868668Recruiting
Low-intensity shockwave versus wave therapy for erectile and pelvic pain
This trial compares two types of low-intensity wave therapy to see which works better for erectile dysfunction and/or chronic pelvic pain. Participants may benefit if these therapies improve erection quality and reduce pelvic pain.
Cleveland, OhioAges 40 years+ - NCT07048366Recruiting
Mindfulness in a museum for fibromyalgia pain relief
This study tests whether a mindfulness program held in a museum setting can help women with fibromyalgia feel less pain and improve their quality of life. You would attend sessions in a museum and practice mindfulness techniques.
Chieti, AbruzzoAges 18–60 - NCT06442514Recruiting
Pain and Smoking Study: Phone Support for Veterans
This study tests a phone-based program to help Veterans with chronic pain quit smoking. If you're a VA patient who uses tobacco and has ongoing pain, you may be able to join and get support from home.
West Haven, ConnecticutAges 18 years+ - NCT07193095Recruiting
Comparing two brief pain relief programs for chronic pain
This study compares two brief programs (mindfulness skills vs. pain relief education) to see which helps adults with chronic muscle or joint pain feel better. You would attend one or two sessions and complete short questionnaires, all from home.
Tallahassee, FloridaAges 18 years+
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.