Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 826 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07351851Recruiting
Exercise for back pain and urine leakage in women
This study tests whether a special exercise program called PEMM (which combines pelvic floor and core exercises) can help women with both chronic low back pain and urinary incontinence. It is designed for women who have had back pain and urine leakage for at least 3 months.
Doha, Baladiyat ad DawhahAges 18–65 - NCT07304076Recruiting
JHG002 Injection for Chronic Low Back Pain
This study tests if JHG002 injections (made from human placenta) are safe and effective for treating chronic low back pain. It may help people who have had low back pain for at least 6 months and rate their pain as a 5 or higher on a 0–10 scale.
Seoul, Gangdong-guAges 19–70 - NCT03852381Recruiting
Spinal cord stimulation for nerve pain after back surgery
This study looks at how spinal cord stimulation (a device that sends mild signals to the spinal cord) affects nerve pain after lumbar surgery. It also aims to help predict who is most likely to improve and why, comparing patients with and without certain sensory symptoms.
Toronto, OntarioAges 18–80 - NCT05507853Recruiting
Study of body pain sensitivity during pregnancy
This study looks at “central sensitization,” which means the nervous system may become more sensitive to pain, in pregnant people. It aims to understand pain changes during pregnancy and how different factors may affect them.
GothenburgAges 18 years+ - NCT05997979RecruitingPhase 3
Capsaicin patch for nerve pain in children after surgery or injury
This trial tests whether a capsaicin 8% skin patch can safely reduce nerve pain in children ages 12 to 17 who have had pain for more than 3 months after surgery or an injury. The patch is applied to the painful area and may offer relief without daily pills.
AmiensAges 12–17 - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07270406Recruiting
Healthy habits for better sleep in people with HIV and pain
This study tests a healthy behaviors program to help prevent insomnia in people with HIV who also have ongoing pain. If you have trouble sleeping and chronic pain, this program may help improve your sleep and well-being.
St Louis, MissouriAges 25–65 - NCT07180407Recruiting
Post-ICU pain study for adults
This study looks at pain after a stay in the intensive care unit (ICU). It aims to understand pain in patients who were urgently admitted to the ICU and stayed for at least two days.
AalborgAges 18 years+ - NCT06910982Enrolling by invitation
Yoga and Mindfulness for Chronic Low Back Pain
This study tests whether a combination of yoga and mindfulness exercises can help reduce chronic lower back pain. It compares this program to usual care, and may be a good fit if your pain is bothersome but you are not too afraid that moving will make it worse.
Karachi, SindhAges 25–45 - NCT05780021Recruiting
Support program for long-term low back pain after rehab
This trial tests whether a structured motivational support program can help people with long-term low back pain after they finish a rehab program. It may help you stay motivated and improve your day-to-day progress after treatment.
ParisAges 18 years+ - NCT07408193RecruitingEarly Phase 1
Lidocaine and ketamine for severe cancer pain not helped by opioids
This trial tests if adding lidocaine and ketamine to your current pain medicines can better control severe cancer-related pain that opioids alone haven't helped.
Athens, AtticaAges 18 years+ - NCT06063902Enrolling by invitation
Long-term opioid therapy for chronic pain
This study looks at the risks and benefits of long-term use of opioids (strong painkillers) for chronic pain that is not caused by cancer. It aims to help doctors and patients make better decisions about pain management.
UppsalaAges 18 years+ - NCT05832918Recruiting
Core exercises plus brain tasks for chronic low back pain
This study tests whether doing core (stability) exercises along with simple cognitive (thinking) tasks can reduce long-lasting low back pain. It may help if your pain has lasted at least 3 months and you can safely take part in exercise.
Tehran, Iran (the Islamic Republic Of)Ages 18–55 - NCT07149870Recruiting
Pain management team for veterans with chronic pain
This study is testing whether a team-based pain management approach helps veterans with chronic pain and long-term opioid use. It aims to improve function and safety by addressing opioid concerns.
Birmingham, AlabamaAges 18 years+ - NCT04267588Recruiting
Using technology to track your chronic pain
This trial uses technology to follow how your pain changes over time and how it affects your daily life. It may help researchers understand pain patterns and improve pain care, as long as you can safely and consistently take part.
Baltimore, MarylandAges 21 years+ - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07133139Recruiting
Dry needling for chronic low back pain
This study tests whether a treatment called dry needling (using thin needles on muscle knots) helps people with long-term low back pain tied to muscle tightness. It is for those who have not tried this treatment before and whose main pain is in the lower back.
Pittsburgh, PennsylvaniaAges 20–70 - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT06466330Recruiting
Knee embolization for post-replacement pain
This trial tests a non-surgical treatment called microparticle geniculate artery embolization for people with persistent knee pain after a total knee replacement. It aims to reduce pain by blocking tiny blood vessels that may be causing inflammation.
CréteilAges 40–80 - NCT06795386Recruiting
Widespread pain after rapid weight loss in Black and Hispanic adults
This study looks at whether rapid weight loss from bariatric surgery leads to long-term widespread pain in Black and Hispanic adults. The goal is to understand how weight loss affects pain and find better ways to help people manage it.
New York, New YorkAges 18–75 - NCT07524751Recruiting
Cultural Pain Management Program for Indigenous People
This study tests a pain management program designed specifically for American Indian and Alaska Native communities. If you have chronic pain (lasting over 3 months), this program teaches coping strategies that respect your culture and background.
Yakima, WashingtonAges 18 years+ - NCT07001631Recruiting
EMDR for pain relief in children with sickle cell disease
This trial tests if EMDR therapy can help children with sickle cell disease reduce pain interference in daily life. If you or your child has sickle cell disease and experiences significant pain, this study may offer a new way to manage it.
AmsterdamAges 6–18 - NCT03434392Recruiting
Testing pain-sensing to predict treatment response in chronic pancreatitis
This study uses a special pain-testing method to better predict how people with chronic pancreatitis-related pain (or similar conditions) will respond to treatment. It may help doctors choose therapies that work better for each person’s type of pain.
Baltimore, MarylandAges 18 years+ - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 826 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.