Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07429773Recruiting
Immune markers in stubborn pelvic pain
This study looks at the immune system's response in people with chronic pelvic pain that hasn't gotten better with first treatments. By measuring certain immune markers, the researchers hope to better understand why the pain persists and find new ways to help.
Nice, Alpes-MaritimesAges 18–40 - NCT07568834Recruiting
How a Podcast Helps People With Chronic Pelvic Pain
This study tests whether listening to a podcast about pelvic pain helps patients feel more informed and supported. You'll be asked to listen to audio content and share your feedback about whether it was helpful.
Nashville, TennesseeAges 18 years+ - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT03168802Recruiting
Ultrasound and nerve treatment for facet-joint low back pain
This study tests whether a procedure that uses focused ultrasound (MRgFUS) and/or a radiofrequency nerve treatment can reduce long-lasting low back pain caused by facet-joint arthritis. It may help people whose pain improves strongly after a targeted numbing injection to specific back nerves.
Taipei, Please SelectAges 20–79 - NCT07507422Recruiting
Post-market study of Inceptiv spinal cord stimulation
This study follows people receiving Inceptiv, a spinal cord stimulator from Medtronic, to see how well it works over time. It is for adults with chronic back or limb pain who have not tried spinal cord stimulation before.
Phoenix, ArizonaAges 18 years+ - NCT07467499Recruiting
How leisure activities affect quality of life in low back pain
This study looks at how your hobbies and free-time activities might improve your quality of life if you have long-term low back pain (pain that lasts 12 weeks or more). You will answer questionnaires about your daily life and what you enjoy doing.
BrusselsAges 18 years+ - NCT07448285RecruitingPhase 3
Platelet-rich plasma injection for chronic shoulder pain
This trial tests whether injecting platelet-rich plasma (a concentration of your own blood cells that may help healing) can reduce chronic shoulder pain. It's for people whose pain hasn't improved with standard painkillers and who have a specific shoulder tendon condition.
Barakaldo, BizkaiaAges 35–75 - NCT07326696Recruiting
Therapy for long-term neck pain with limited movement
This trial tests a combination of hand-on treatments (a quick push to the upper back and gentle movements to the neck) to see if it helps people with ongoing neck pain and stiffness. It might be an option if you've had neck pain for more than 3 months and have trouble moving your neck or upper back.
Islamabad, Punjab ProvinceAges 20–40 - NCT07222462Recruiting
Radiofrequency ablation for chronic low back pain
This study tests if radiofrequency ablation, a procedure that uses heat to block pain signals from the facet joints in your spine, can help people with long-term low back pain that hasn't improved with other treatments like physical therapy.
Atlanta, GeorgiaAges 18 years+ - NCT07193212Recruiting
Osteopathic treatment for low back pain and leg health
This study tests whether a hands-on osteopathic treatment can improve how your legs and feet work if you have chronic low back pain. It may help you understand if this type of manual therapy is a good option for your pain.
Auburn, AlabamaAges 18–65 - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT06619418Recruiting
Home Device Using Sound and Body Stimulation for Back Pain
This study is testing a take-home device that uses sound and gentle body stimulation to help with long-term back pain. It is for adults with chronic low back pain who live near the University of Minnesota and are not taking certain sleep or anxiety medications.
Minneapolis, MinnesotaAges 18 years+ - NCT06404983Recruiting
Opioid-free anesthesia for breast cancer surgery
This study tests whether breast cancer surgery can be done safely without using opioid pain medicines during anesthesia. The goal is to see if avoiding opioids leads to fewer side effects and a smoother recovery.
Ioannina, EpirusAges 18–99 - NCT05094297Recruiting
Study of muscle contraction training for veteran tiredness and pain
This study tests whether a guided exercise approach using focused muscle contractions can improve pain, fatigue, or low energy in U.S. Veterans. If you’re having trouble doing everyday activities, this program may help you feel better and function more easily.
Chicago, IllinoisAges 18 years+ - NCT06354699Recruiting
Pain after surgery in children: a long-term study
This study looks at children who have certain types of surgery to understand who might have ongoing pain, what causes it, and how it affects them over time.
San Francisco, CaliforniaAges Up to 16 years - NCT06263907Recruiting
Nerve block to prevent depression after mastectomy
This study tests whether a nerve block near the neck (stellate ganglion block) can help prevent depression after mastectomy for breast cancer. It is for women who are generally healthy and have no history of mood disorders.
Al MansurahAges 21–65 - NCT05853640Recruiting
Education and exercise for long-term hip or groin pain
This trial tests whether a program of education plus exercise can reduce long-term hip or groin pain. It may help by improving movement and function, especially when pain has lasted more than 3 months.
MalmöAges 18–55 - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT07645859Recruiting
High-Intensity vs. Moderate Exercise for Chronic Lower Back Pain
This trial compares two types of exercise programs—one with short, intense bursts of activity and one with steady, moderate activity—to see which works better for people with long-lasting lower back pain that has no clear medical cause. You would participate in supervised exercise sessions over several weeks.
KarachiAges 20–48 - NCT07296653RecruitingEarly Phase 1
Prolotherapy for chronic low back pain
This trial tests a treatment called prolotherapy, which uses injections of a sugar solution into specific acupuncture points to help relieve chronic low back pain. It is for people who have had low back pain for at least 3 months, have not had previous back surgery, and have not received similar injections recently.
Athens, AtticaAges 35 years+ - NCT06602349Recruiting
Lidocaine injection for chronic anal/perineal pain
This trial tests whether injecting a numbing medicine (lidocaine) into the painful area helps people with chronic, unexplained pain in the anal or perineal region. It is for patients who have not gotten relief from standard treatments and whose MRI shows no other cause.
Paris, Île-de-France RegionAges 18 years+ - NCT06892977Enrolling by invitation
Stress and pain interaction study
This study looks at how stress affects pain sensitivity and how the brain processes pain. It uses MRI scans to see brain activity while participants experience mild pain, which may help improve pain treatments.
GhentAges 18–55 - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.