Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 826 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06814808Enrolling by invitation
Comparing three treatments for chronic neck pain
This study compares three different treatments for chronic neck pain caused by trigger points (tender knots in muscles). It aims to find which approach works best for pain relief and improved function.
Istanbul, ZeytinburnuAges 18–65 - NCT07302958Recruiting
Comparing remote, in-person, and mixed exercise for neck pain
This trial compares three ways to treat chronic neck pain: doing exercises at home with remote guidance, doing them in a clinic with a therapist, or a mix of both. It aims to find which method works best for people with ongoing neck pain.
CairoAges 20–45 - NCT05922007Recruiting
Study of chronic pain effects on daily life
This study looks at how long-lasting pain and its treatment affect quality of life and physical activity. It asks people to complete questionnaires to understand what changes over time.
Ostrava, Moravian-Silesian RegionAges 18–65 - NCT06778460Recruiting
Esketamine and lidocaine for pain after liver surgery
This trial tests whether two medicines, esketamine and lidocaine, can reduce long-term pain after liver surgery and possibly improve survival. It is for people who are having a planned liver removal (hepatectomy).
Chengdu, SichuanAges 18–75 - NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+ - NCT06373978RecruitingPhase 4
Non-narcotic pain relief after elbow needle procedure
This study tests non-narcotic pain medicine after a needle procedure for chronic elbow tendon pain. It compares different pain-relief options to find what works best without opioids.
Coral Springs, FloridaAges 18–65 - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT07251959Enrolling by invitation
Exercise vs. exercise plus manual therapy for chronic back pain
This study tests whether a workplace exercise program, with or without hands-on manual therapy, can help reduce chronic spinal pain in desk workers. It is designed for UCAM University staff who have had persistent back pain for at least 3 months.
Murcia, MurciaAges 18 years+ - NCT07032350Recruiting
Pain management app for dementia caregivers
This study tests a mobile app that helps family caregivers of people with dementia manage their loved one's chronic pain. It aims to see if the app is easy to use and helpful for caregivers.
Iowa City, IowaAges 18–100 - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT07688915Recruiting
High-intensity laser vs. steroid injection for chronic back and leg pain from a herniated disc
This study compares two treatments for long-lasting low back and leg pain caused by a herniated disc: high-intensity laser therapy and a steroid shot near the spine. Researchers want to see which option works better to reduce pain.
AnkaraAges 18–65 - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06758414Recruiting
CBT for chronic pain in veterans with serious mental illness
This trial tests a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain, designed for veterans with serious mental illness. It aims to help you manage back pain and improve your quality of life.
Baltimore, MarylandAges 18 years+ - NCT06827262Recruiting
A procedure for vertebrogenic back pain relief
This trial tests a minimally invasive procedure that uses a special device to target and treat nerve-related back pain coming from the vertebrae (the bones in your spine). It may offer lasting relief without more major surgery.
Flagstaff, ArizonaAges 18 years+ - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+ - NCT05677412Recruiting
Studying sleep, stress, and pain in teens with ongoing pain
This study looks at how sleep and stress relate to pain that keeps coming back in teens. It may help researchers understand what could improve comfort and daily functioning when pain lasts more than three months.
HelsinkiAges 15–17 - NCT06507267Recruiting
Pain and symptoms in pelvic congestion syndrome
This study looks at how pain and other symptoms relate to a condition called pelvic congestion syndrome, which happens when veins in the pelvis become enlarged. It may help doctors better understand and treat this cause of long-term pelvic pain.
IstanbulAges 18–50 - NCT07160621Recruiting
Pain management app for teen cancer survivors
This trial tests a culturally adapted mobile app to help teen cancer survivors manage chronic pain and improve daily functioning. It compares the app to standard care to see if it reduces pain interference.
Memphis, TennesseeAges 10–17 - NCT06168604Recruiting
Pain communication toolkit for dementia caregivers
This trial tests a toolkit to help caregivers of adults with dementia and chronic pain better identify and communicate about their loved one's pain. You and the person you care for may join if you meet the listed requirements.
New York, New YorkAges 21 years+ - NCT07732062Recruiting
Emotion-focused therapy for chronic pain patients using medical cannabis
This study tests a new type of talking therapy (vEAET-H) to see if it helps people with chronic pain who are already using medical cannabis. The goal is to find out if adding this therapy can improve pain and well-being.
Tel AvivAges 18 years+ - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06915896Recruiting
Chronic back or neck pain: predicting therapy outcomes
This study looks at people with long-term low back or neck pain who are waiting for physical therapy. It aims to find what factors predict how well they will do with different treatment paths.
Florence, FIAges 18 years+
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 826 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.