Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 828 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06704490Recruiting
Chronic pain after planned cesarean section
This study looks at how common chronic pain is after a planned cesarean section and what factors might increase that risk. It could help doctors better prevent and manage long-term pain after delivery.
Wuhan, HubeiAges 20–50 - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT07306312Enrolling by invitation
How thoughts affect low back pain with manual therapy
This study looks at how your thoughts and feelings about your chronic low back pain affect your pain and ability to move, during a course of manual therapy (hands-on treatment by a therapist). It may help you understand if your mindset influences your recovery.
AthensAges 18–65 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT06544525Recruiting
Pain test to predict physical therapy results for back pain
This trial tests whether a simple pain test can predict how much you will improve with physical therapy for chronic low back pain. It looks at how your body naturally handles pain, which may help tailor your treatment.
Fort Sam Houston, TexasAges 18–64 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80 - NCT07000409Recruiting
Ultrasound-guided nerve block for shingles pain
This trial tests if a nerve block with betamethasone can reduce long-term shingles pain on the trunk. It may help people who still have pain more than 3 months after the rash appeared.
CairoAges 18–75 - NCT07195162Recruiting
Testing a digital tool for pain management
This trial is testing a digital workflow system to help doctors manage pain. It may be a good fit if you've had pain lasting at least a month.
HaifaAges 18–80 - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT06414356RecruitingPhase 4
Ketamine for nerve pain and PTSD in military personnel
This study tests whether ketamine infusions can help with ongoing nerve pain and PTSD symptoms. It's for active-duty service members, veterans, and retirees who have had moderate nerve pain for at least 3 months.
San Antonio, TexasAges 18–70 - NCT06506708Recruiting
Massage and hydrotherapy for endometriosis pain
This study tests whether combining massage and water therapy can reduce pain and improve well-being in people with endometriosis. If you have had pelvic pain for at least 6 months, this trial might help you find relief.
GranadaAges 18–55 - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT07632820RecruitingPhase 4
Nerve Block vs. Injection for Upper Back Muscle Pain
This study compares two ways to treat chronic muscle pain in the upper back: a nerve block (numbing injection near the spine) and trigger point injections (shots directly into painful muscle knots). The goal is to see which approach works better for long-lasting relief.
Jacksonville, FloridaAges 18–80 - NCT05840302Recruiting
Pain education program to increase activity in chronic low back pain
This trial studies whether teaching “pain neuroscience” (how pain works in the body and brain) helps people with long-term low back pain move more. It compares an education program as part of a multidisciplinary rehab to usual care during your planned hospital stay.
Lamalou-les-BainsAges 18 years+ - NCT07536672Enrolling by invitation
Understanding Pain and Sexual Health in Chronic Pain
This study helps develop a questionnaire (survey) that measures how chronic pain affects sexual health and relationships. If you have long-term pain and a stable relationship, your feedback could help doctors better understand and support patients like you.
Kütahya, KütahyaAges 18 years+ - NCT07692126Recruiting
Neck pain and hand strength: core vs shoulder exercises
This study compares two types of exercises to see which better improves hand grip strength and neck pain. If you have had chronic myofascial neck pain (trigger points) in the upper shoulder muscle for over 6 months, this trial may help find which exercise works best for you.
Giza, Giza GovernorateAges 25–45 - NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 828 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.