Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07195162Recruiting
Testing a digital tool for pain management
This trial is testing a digital workflow system to help doctors manage pain. It may be a good fit if you've had pain lasting at least a month.
HaifaAges 18–80 - NCT07000409Recruiting
Ultrasound-guided nerve block for shingles pain
This trial tests if a nerve block with betamethasone can reduce long-term shingles pain on the trunk. It may help people who still have pain more than 3 months after the rash appeared.
CairoAges 18–75 - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT06414356RecruitingPhase 4
Ketamine for nerve pain and PTSD in military personnel
This study tests whether ketamine infusions can help with ongoing nerve pain and PTSD symptoms. It's for active-duty service members, veterans, and retirees who have had moderate nerve pain for at least 3 months.
San Antonio, TexasAges 18–70 - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT07632820RecruitingPhase 4
Nerve Block vs. Injection for Upper Back Muscle Pain
This study compares two ways to treat chronic muscle pain in the upper back: a nerve block (numbing injection near the spine) and trigger point injections (shots directly into painful muscle knots). The goal is to see which approach works better for long-lasting relief.
Jacksonville, FloridaAges 18–80 - NCT07536672Enrolling by invitation
Understanding Pain and Sexual Health in Chronic Pain
This study helps develop a questionnaire (survey) that measures how chronic pain affects sexual health and relationships. If you have long-term pain and a stable relationship, your feedback could help doctors better understand and support patients like you.
Kütahya, KütahyaAges 18 years+ - NCT05840302Recruiting
Pain education program to increase activity in chronic low back pain
This trial studies whether teaching “pain neuroscience” (how pain works in the body and brain) helps people with long-term low back pain move more. It compares an education program as part of a multidisciplinary rehab to usual care during your planned hospital stay.
Lamalou-les-BainsAges 18 years+ - NCT07692126Recruiting
Neck pain and hand strength: core vs shoulder exercises
This study compares two types of exercises to see which better improves hand grip strength and neck pain. If you have had chronic myofascial neck pain (trigger points) in the upper shoulder muscle for over 6 months, this trial may help find which exercise works best for you.
Giza, Giza GovernorateAges 25–45 - NCT07856498Recruiting
Understanding pain and movement in postmenopausal women with low back pain
This study looks at how thoughts and fears about pain affect physical activity in women after menopause who have chronic low back pain. The goal is to learn more about these connections to help improve future treatments.
Istanbul, IstanbulAges 45–65 - NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT07607899Recruiting
Virtual Reality to Help Chronic Pain in Older Adults
This study tests whether wearing a virtual reality headset can help reduce chronic pain and improve well-being in people 65 and older. Researchers believe VR may help you manage long-lasting pain by engaging your mind in immersive experiences.
Québec, QuebecAges 65 years+ - NCT07541599Recruiting
Mind-Body Skills for Rural Veterans With Chronic Pain
This study tests whether online mind-body techniques (like meditation and breathing exercises) can help rural veterans manage chronic pain. You'll attend remote sessions and learn skills to reduce how much pain interferes with daily life.
Minneapolis, MinnesotaAges 18 years+ - NCT06327542Recruiting
Group pain management in primary care clinics
This trial tests a group-based program to help people with chronic pain manage their symptoms. It is offered in primary care clinics that serve underinsured communities, and sessions are available in English or Spanish.
San Francisco, CaliforniaAges 18 years+ - NCT06139510Recruiting
Understanding Pain in Sickle Cell Disease
This study looks at what causes pain in people with sickle cell disease. They hope to learn more about pain patterns to better help patients manage it.
Durham, North CarolinaAges 15–40 - NCT05811312Recruiting
Spinal cord stimulation and brain changes in chronic pain
This study uses non-invasive brain monitoring to see how spinal cord stimulation may change brain activity in people with chronic nerve pain. It aims to better understand how treatment affects the brain and pain over time.
Cleveland, OhioAges 18 years+ - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT07418632Recruiting
Motion training for neck pain using smart classification
This study tests a special motion-training program for people with neck pain. It uses a computer to classify and guide your movements, which may help reduce pain better than usual care.
LjubljanaAges 18–65 - NCT07150143Recruiting
Massage and exercises for chronic neck pain
This trial tests whether adding a special type of massage (connective tissue massage) and other physical therapies to standard neck stabilization exercises helps people with long-term neck pain feel better.
Ataşehir, IstanbulAges 18–65
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.