Clinical trials
Chronic Postoperative Pain clinical trials
Below are recruiting chronic postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 297 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07472959RecruitingPhase 4
Morphine for pain after heart bypass surgery
This study tests whether giving morphine during coronary artery bypass surgery can help control pain after the operation. It is for people having planned heart bypass surgery who are moderately sick and not already on strong pain medicines.
Istanbul, Outside of the USAges 18–80 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT06602271RecruitingPhase 3
Study of PF614 for Pain After Tummy Tuck Surgery
This study tests a new painkiller called PF614 for pain after tummy tuck surgery. It compares the study drug to a placebo (a pill with no medicine) to see how well it works and how safe it is.
Atlanta, GeorgiaAges 18–75 - NCT06905340Recruiting
Pain-guided opioid use during surgery with regional anesthesia
This trial uses a special monitor (NOL index) to help doctors give just the right amount of pain medicine during surgery. It is for people having trauma or orthopedic surgery who are also getting regional anesthesia.
HamburgAges 18 years+ - NCT07268495Recruiting
Lidocaine spray to reduce pain after fibroid surgery
This trial tests if spraying lidocaine (a numbing medicine) inside the belly along with lidocaine given through an IV can lower pain after surgery to remove uterine fibroids. It may help you have less pain and recover more comfortably.
Yinchuan, NingxiaAges 18–65 - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT07712211Recruiting
Pain Catastrophizing and Nausea After Gallbladder Surgery
This study looks at how a person's tendency to focus on and feel overwhelmed by pain (called 'pain catastrophizing') might affect nausea and vomiting after gallbladder surgery. If you are scheduled for keyhole gallbladder removal, you may help doctors better predict and prevent post-surgery nausea.
TrabzonAges 18–65 - NCT07568405Enrolling by invitation
How Remifentanil Affects Pain Sensitivity During Surgery
This study tests how a pain-relief medication called remifentanil changes the way your body responds to pressure pain. Researchers will measure your pain sensitivity before and after receiving this medication to better understand how it works.
Brussels, Brussels CapitalAges 18–65 - NCT05120076RecruitingPhase 3
Dexamethasone during surgery to reduce hip surgery pain and nausea
This trial tests whether a single steroid medicine called dexamethasone given around the time of surgery can reduce pain and nausea after a periacetabular osteotomy. It may help you feel more comfortable in the first days after surgery, depending on your medical history.
ZurichAges 18–99 - NCT07610408Recruiting
Pain Relief Methods After Chest Surgery Nerve Block Wears Off
This study compares different intravenous (IV) pain medications given after a regional anesthetic nerve block stops working in patients having minimally invasive chest surgery. The goal is to find the most effective pain management strategy for recovery.
Ankara, KeçiörenAges 18–80 - NCT06384664Recruiting
Freezing Nerves to Reduce Pain After Chest Surgery
This study tests whether freezing a nerve (cryoablation) during chest surgery can reduce pain after the operation. It might help patients who are having their first chest surgery and have never used strong painkillers.
Ann Arbor, MichiganAges 18 years+ - NCT07743606Enrolling by invitationPhase 3
Pain medicine after lower back fusion surgery
This study tests whether taking a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen after lumbar spine fusion surgery is safe and helps with pain without affecting bone healing. It may offer an alternative to stronger pain medicines.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05906134RecruitingPhase 1/Phase 2
Pain control plan after minimally invasive esophagus surgery
This trial tests a pain-control method (using an epidural/nerve pain-block through the back, called neuraxial anesthesia) for people having minimally invasive esophagus removal surgery. It may help reduce pain after surgery and improve comfort during recovery.
Seattle, WashingtonAges 18 years+ - NCT06918470Recruiting
Do noise cancelling headphones help with pain after surgery?
This study tests whether wearing noise cancelling headphones after gynecologic laparoscopy can reduce pain. If you are a woman having this surgery, you may be able to participate.
Wuhan, HubeiAges 18–55 - NCT07023497Recruiting
Finding the best dose of spinal morphine for C-section pain relief
This study tests different doses of morphine given through a spinal injection during a planned C-section to find the best balance of pain relief and side effects. It may help women have better pain control after surgery.
Ioannina, EpirusAges 18–50 - NCT07435909Recruiting
Bupivacaine for pain after laparoscopic hysterectomy
This trial tests if injecting a numbing medicine called bupivacaine into the abdomen during surgery can reduce pain after a laparoscopic hysterectomy (uterus removal through small cuts). It may help you recover with less discomfort.
Istanbul, GaziosmanpaşaAges 35–75 - NCT07446868Recruiting
Comparing two nerve blocks for pain after mastectomy
This trial compares two nerve-block techniques (SPSIP and ESPB) to see which one provides better pain relief after breast cancer surgery. The goal is to reduce pain and improve recovery after a modified radical mastectomy.
Cairo, Cairo GovernorateAges 18–65 - NCT05009771Recruiting
Testing a pain-control method after C-section
This study looks at how to better manage pain after a C-section using spinal anesthesia and either a patient-controlled IV pain pump or a specific pain medicine (naldebaein). You may be able to join if you’re scheduled for a C-section at 37–40 weeks and can take the usual pain medicines.
New Taipei City, TaiwanAges 20–40 - NCT06957158Recruiting
How calcium levels affect pain after abdominal surgery
This study looks at whether calcium levels in your blood can affect how much pain you feel after abdominal surgery. It may help doctors manage pain better after surgery in the future.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT07377370Recruiting
Pain after gum graft surgery study
This study looks at factors that affect pain after a gum graft procedure. If you need gum surgery to cover exposed tooth roots or add gum tissue, you may be able to join.
Barcelona, Sant Cugat Del VallesAges 18 years+ - NCT07396545Recruiting
Comparing two types of nerve blocks for pain after stomach cancer surgery
This trial looks at two different pain-blocking injections (nerve blocks) to see which one works better for pain after keyhole stomach cancer surgery. If you are having this type of surgery, joining could help us learn which block gives you better pain relief.
Yinchuan, NingxiaAges 18 years+ - NCT07496086Recruiting
Comparing two nerve blocks for stomach surgery pain
This trial compares two types of nerve blocks to see which one reduces pain better after laparoscopic stomach cancer surgery. If you qualify, you'll help doctors find the best way to manage pain with fewer side effects.
YinchuanAges 18 years+ - NCT07285083Recruiting
Pain relief after abdominal surgery: comparing two numbing medicines
This study compares two numbing medicines (bupivacaine alone vs. bupivacaine plus dexmedetomidine) to see which provides better pain relief after abdominal surgery. If you are having a planned abdominal operation, this trial may help improve your recovery comfort.
Rahim Yar Khan, Punjab ProvinceAges 21–45 - NCT07334288Recruiting
Numbing injection for pain relief after lower back surgery
This study tests a numbing injection near the spine (retrolaminar block) to reduce pain after lower back surgery with hardware. It could help you use less pain medicine and recover more comfortably.
Santiago, Santiago MetropolitanAges 18–80
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Common questions
- Are there clinical trials for chronic postoperative pain?
- Yes. Clin2 currently lists 297 recruiting chronic postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain
- Postoperative Pain, Acute
- Postoperative Pain Management
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.