Clinical trials
Clostridium Difficile clinical trials
Below are recruiting clostridium difficile clinical trials, each written for real people, not researchers. We’re tracking 19 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06839209Recruiting
Add-on TOXCLEAN for recurrent C. difficile diarrhea
This trial tests an add-on treatment called TOXCLEAN for people with repeat C. difficile diarrhea. It aims to see if adding TOXCLEAN to standard antibiotics helps more than antibiotics alone.
RomaAges 18 years+ - NCT03562741Recruiting
Tracking outcomes of fecal transplant for repeated C. difficile
This study looks at how fecal microbiota transplantation (a transplant of healthy gut bacteria) works for people who get C. difficile infection repeatedly. It also focuses on collecting follow-up information to better understand which patients benefit and how.
Worcester, MassachusettsAges 16 years+ - NCT04305769RecruitingPhase 2
Alanyl-glutamine to help treat C. difficile diarrhea
This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.
Charlottesville, VirginiaAges 18–105 - NCT06237452RecruitingPhase 3
VE303 to prevent repeat C. diff infections
This trial tests a new medicine called VE303, a live bacterial therapy, to prevent C. diff infections from coming back. It is for people who have had C. diff at least once in the last 6 months, or who are at high risk for a repeat infection due to age or other health problems.
Huntsville, AlabamaAges 12 years+ - NCT02127398RecruitingPhase 2
Fecal transplants for hard-to-treat C. difficile infection
This Phase 2 study tests whether placing stool from a healthy donor into your gut can treat repeated, hard-to-control C. difficile colitis. It may help restore healthy gut bacteria and reduce future flare-ups.
Durham, North CarolinaAges 18 years+ - NCT06703918Recruiting
C. Diff Infection Study in Babies
This study looks at Clostridium difficile (C. diff) infections in babies under 2. It compares babies who have the infection with those who don't, using medical records to learn more about how it affects them.
Hangzhou, Zhejiang, ChinaAges birth–2 years - NCT07513285RecruitingPhase 2
Ibezapolstat pill for recurrent C. difficile infection
This trial tests a new oral antibiotic called ibezapolstat to treat recurrent C. difficile infection (CDI)—a serious diarrheal illness caused by bacteria in your gut. The study focuses on patients who have had multiple CDI episodes and may benefit from a different treatment approach.
Sacramento, CaliforniaAges 18–90 - NCT01868373Enrolling by invitationPhase 1
Fecal transplant study for hard-to-treat C. difficile diarrhea
This Phase 1 study tests defined fecal microbiota (healthy gut bacteria) given to people with C. difficile diarrhea that didn’t go away or came back soon after antibiotics. It may help by restoring a healthier balance of gut bacteria so the infection can stop recurring.
Houston, TexasAges 18 years+ - NCT07221370RecruitingPhase 2/Phase 3
Vancomycin to prevent C. diff infection in ICU patients
This trial tests whether giving vancomycin through a tube into the stomach can prevent a serious gut infection called C. diff in people who are very sick in the ICU and taking antibiotics. If you qualify, you might receive this medicine to lower your risk.
Moreno Valley, CaliforniaAges 18 years+ - NCT06030245Recruiting
Tracking recovery from C. diff infection in hospital patients
This study follows patients with Clostridioides difficile (C. diff) infection to see how their symptoms improve and when the bacteria clear from their body. It aims to better understand recovery and guide treatment.
ParisAges 18 years+ - NCT06859437Recruiting
Preventing C. diff infection with a probiotic in transplant patients
This trial tests whether a probiotic called Lactobacillus plantarum can help prevent Clostridium difficile (C. diff) infections in people who have had an organ transplant or are on immune-suppressing drugs and are taking antibiotics. If you qualify, you may get a probiotic that could reduce your risk of this serious gut infection.
Poland, Silesian VoivodeshipAges 18 years+ - NCT06258551Recruiting
Tracking hard-to-treat bacteria in ICU and transplant patients
This study will track how certain hard-to-treat bacteria spread and cause infections in people who are in the intensive care unit (ICU) or have had a stem cell transplant. The goal is to better understand and prevent these infections in vulnerable patients.
Houston, TexasAges 18 years+ - NCT03325855Recruiting
Fecal transplant registry for patients and donors
This study is a national “registry” that collects information from people who get fecal microbiota transplant (a stool-based treatment) and from people who donate stool. It helps researchers understand who receives these treatments and how they do over time.
Phoenix, ArizonaAges Any age - NCT04014413Recruiting
Fecal transplant for gut and immune-related conditions
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
Hong Kong, ShatinAges Any age - NCT06071312RecruitingPhase 1/Phase 2
Fecal transplant for C. diff and ulcerative colitis
This trial tests whether one or multiple fecal transplants from a healthy donor can help treat both a recurring C. diff infection and active ulcerative colitis. It aims to find the best schedule for the procedure.
RomeAges 18–75 - NCT06311006Recruiting
Safety registry for fecal transplant for C. diff
This registry tracks people who receive a fecal microbiota transplant (FMT) for a serious or repeat C. diff infection. It helps doctors better understand how safe and effective FMT is in real-world use.
ParisAges 18 years+ - NCT07261826Recruiting
Long-term effects of fecal microbiota transplant
This study looks at how well fecal microbiota transplantation (FMT) works over time and checks its safety. If you have received at least one FMT for a qualifying condition, you may be able to participate.
Shanghai, Shanghai MunicipalityAges 3 years+ - NCT01905709Recruiting
Fecal transplant to treat recurring C. difficile infection
This trial studies using a fecal microbiota transplant (FMT)—healthy gut bacteria moved from a screened donor—to help treat recurring or hard-to-control C. difficile infection. It may help restore a healthier gut environment when standard treatments keep failing or the infection returns.
Englewood, New JerseyAges 18 years+ - NCT02636517Enrolling by invitationPhase 1
Fecal microbiome transplant for repeat C. difficile infection
This Phase 1 study tests whether transferring healthy gut bacteria (a fecal microbiome transplant) can help children with repeated or moderate-to-severe C. difficile infection. It focuses on changing gut bacteria to reduce ongoing infection and symptoms.
Philadelphia, PennsylvaniaAges 3–21
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Common questions
- Are there clinical trials for clostridium difficile?
- Yes. Clin2 currently lists 19 recruiting clostridium difficile studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clostridium difficile trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clostridium difficile trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.