Clinical trials
Cognitive Dysfunction clinical trials
Below are recruiting cognitive dysfunction clinical trials, each written for real people, not researchers. We’re tracking 152 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07000500Enrolling by invitation
Nutritional supplement for memory decline in older adults
This trial tests whether a nutritional supplement can help slow or improve memory loss in older adults who have mild cognitive decline (noticeable changes in thinking skills that are not yet dementia). You will take a daily supplement and attend regular check-ups.
Vila Nova de Famalicão, Braga DistrictAges 65 years+ - NCT07171450Recruiting
Thinking skills training for older adults after COVID-19
This study tests a computer-based program to help improve memory and thinking in older adults who have ongoing cognitive problems after COVID-19. You may qualify if you are 60 or older and have had lasting thinking concerns since your infection.
Farmington, ConnecticutAges 60 years+ - NCT07736885Recruiting
Hand stimulation for thinking problems after stroke
This study tests a gentle, painless electrical stimulation on specific points on the hands to see if it helps improve thinking and memory after a stroke. It is for people who have had a stroke in the last 2 weeks to 6 months and are noticing some cognitive changes.
Tianjin, Tianjin MunicipalityAges 35–80 - NCT05372172Recruiting
Tennessee Alzheimer’s study for people 60 and older
This study is looking at how brain and memory changes show up in people across the Alzheimer’s spectrum—from normal thinking to mild memory problems to Alzheimer’s disease. You might join if you can do study visits and an MRI and have a reliable study partner available.
Nashville, TennesseeAges 60 years+ - NCT07125170Recruiting
Virtual reality for thinking skills after stroke
This trial tests whether immersive virtual reality can help improve thinking and memory problems after a recent stroke. It is designed for people who have mild to moderate cognitive issues and are already scheduled for occupational therapy.
Independencia, Santiago MetropolitanAges 18 years+ - NCT05965518Recruiting
High-intensity exercise for brain and blood-vessel health in HIV
This trial tests whether high-intensity exercise can improve blood-vessel health and brain function in adults with HIV who are not very active and have thinking/memory problems. If you qualify, you’ll be asked to safely complete exercise and other study assessments.
Birmingham, AlabamaAges 50 years+ - NCT07483151Recruiting
Heart Surgery and Thinking Changes Study
This study looks at how changes in blood flow (called venous congestion) after heart surgery might affect thinking and memory. It aims to find out if there is a link between how blood returns to the heart and brain function after surgery.
Yangzhou, JiangsuAges 18 years+ - NCT06088212Recruiting
Heart failure treatment to help thinking and memory
This trial tests whether better managing heart failure after a hospital stay can protect against thinking and memory problems. It is for people who have heart failure and have had some cognitive difficulties.
Hobart, TasmaniaAges 18 years+ - NCT03175302Recruiting
Test digital clock-memory screening before surgery
This study checks a digital “clock drawing” test done before surgery to see how well it measures thinking and memory. It may help improve how doctors screen patients before an operation.
Gainesville, FloridaAges 65 years+ - NCT06507254Recruiting
Polyphenols and brain health in aging
This study tests whether eating more polyphenols (natural compounds in plants) can protect brain health in people at higher risk for Alzheimer's disease, especially if they currently eat a typical Western diet. Participants will be followed over time to see if changes in diet affect thinking and memory.
Los Angeles, CaliforniaAges 50 years+ - NCT07226674Recruiting
Study of gut health and plant nutrients for brain health
This trial tests whether a natural plant compound can help support memory and thinking in people at higher risk for Alzheimer's disease. You may qualify if you are over 50, overweight, eat a typical Western diet, and have a family history of Alzheimer's.
ColeraineAges 50 years+ - NCT03774420Recruiting
Study of memory and thinking changes after breast surgery
This trial looks at whether certain anesthesia medications and airway devices are linked to short-term memory or thinking problems after breast surgery. If you’re having breast surgery under general anesthesia, your care team may compare outcomes to learn how to reduce “post-op cognitive dysfunction.”
Treviso, TVAges 18 years+ - NCT06363396Recruiting
Brain scan study for fatigue after stem cell transplant
This study uses a special brain scan (PET) to look at why people feel very tired or have trouble thinking clearly after a stem cell transplant. It aims to better understand these problems to help future patients.
StockholmAges 20–75 - NCT06704451Recruiting
IL-33 and memory after major abdominal surgery
This study looks at whether a protein called IL-33 is linked to memory and thinking problems that can happen after major abdominal surgery. It may help doctors find patients at risk earlier.
Kunming, YunnanAges Any age - NCT06005363Recruiting
Brain fluid study in shunt surgery patients
This study looks at brain fluid and drainage function in patients receiving a VP shunt for hydrocephalus. It may help understand how the brain clears waste products.
TaoyuanAges 60 years+ - NCT06741566RecruitingEarly Phase 1
Nasal spray before heart bypass to protect memory
This study tests whether a nasal spray containing dexmedetomidine or insulin, given before heart bypass surgery, can help prevent memory and thinking problems that sometimes happen after the operation. It is for adults 60 and older.
Al FayyumAges 60–75 - NCT07413562Recruiting
Nerve stimulation for memory problems after brain injury
This trial tests whether stimulating a nerve in the wrist (median nerve) can help improve thinking and memory problems in people who have had a recent traumatic brain injury. It is for adults with moderate injuries who have trouble with memory and thinking.
Beijing, Beijing MunicipalityAges 18–64 - NCT07483047Recruiting
Predicting memory changes after heart surgery in older adults
This study looks at older adults having heart surgery to find out who might have trouble thinking or remembering afterward. Researchers hope to build a tool to predict this risk so doctors can help sooner.
ShanghaiAges 65 years+ - NCT06238492Recruiting
Boosting brain speed after spinal cord injury
This trial tests a program to help improve how quickly your brain processes information after a recent spinal cord injury. It focuses on people who are about 6 months post-injury.
Englewood, ColoradoAges 18–59 - NCT04289142RecruitingPhase 4
Testing memory effects of dexmedetomidine during heart surgery
This study looks at how a sleep medicine called dexmedetomidine affects thinking and memory after heart surgery. It compares cognitive outcomes over time to see if this sedation choice changes long-term brain function.
Vancouver, British ColumbiaAges 60 years+ - NCT06793735Recruiting
Virtual reality app for memory and thinking problems
This trial tests a virtual reality app you can use at home to help with early memory or thinking problems. It may be an option if you have mild cognitive impairment or notice your thinking is slowing down.
Messina, ItalyAges 40–80 - NCT07365696Recruiting
Fatigue and brain fog after stem cell transplant
This trial looks at the causes of fatigue and cognitive problems (like memory or concentration issues) after a stem cell transplant. It uses old PET scans to study possible damage in the brain.
StockholmAges 20–75 - NCT05616559Recruiting
Precision-guided treatment for single-episode depression
This study tests a more personalized approach to treating depression in people who have had one episode. It uses questionnaires and brain scans (for some participants) to help decide which treatment approach may work best.
CopenhagenAges 18–65 - NCT06452264Recruiting
Early cognitive training for thinking speed after spinal cord injury
This study tests a computer-based training program to help people with recent spinal cord injury improve how quickly they process information. It aims to see if early cognitive training can help with thinking speed after injury.
East Hanover, New JerseyAges 18–65
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Common questions
- Are there clinical trials for cognitive dysfunction?
- Yes. Clin2 currently lists 152 recruiting cognitive dysfunction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive dysfunction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive dysfunction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.