Clinical trials
Cognitive Dysfunction clinical trials
Below are recruiting cognitive dysfunction clinical trials, each written for real people, not researchers. We’re tracking 152 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06215274Recruiting
Leisure activities and early Alzheimer's study
This trial looks at how engaging in mentally stimulating leisure activities (like puzzles, reading, or games) may affect brain health in people with early memory concerns. Researchers want to understand the brain changes that happen with these activities.
Fuzhou, FujianAges 60 years+ - NCT07598552Recruiting
Brain Function Changes After Same-Day Hip or Knee Surgery
This study checks whether patients who have hip or knee replacement surgery and go home the same day experience any temporary changes in thinking or memory. Researchers want to understand how anesthesia and surgery affect the brain in the short term.
SvendborgAges 70 years+ - NCT02613546Recruiting
Cognitive therapy for sexual difficulties in women
This trial studies whether cognitive behavioral therapy (a structured talk-therapy approach) can improve sexual problems. You may be eligible if your sexual function score is low, but not if you have moderate or severe depression/anxiety symptoms or start hormone therapy after beginning the group sessions.
Salvador, Estado de BahiaAges 18–59 - NCT05565833RecruitingPhase 2
Online sleep program for insomnia and thinking problems
This Phase 2 study tests an internet-based sleep program to help older adults with insomnia and related thinking difficulties. It may help improve sleep and reduce how much tiredness and sleep disruption affect daily life.
Charlottesville, VirginiaAges 65 years+ - NCT06546917Recruiting
Cognitive training trial for mild depression with brain scans
This trial tests a computer-based cognitive training program (bWell-D) to see if it can improve thinking skills like memory and focus in people with mild depression. You will also have an MRI brain scan to see how the training affects your brain.
Vancouver, British ColumbiaAges 19–55 - NCT06095297Recruiting
Cognitive rehab for brain fog from long COVID
This study tests a computer-based cognitive training program combined with a gentle nerve stimulation device to see if it can improve brain fog and daily functioning in people with long COVID. If you're struggling with thinking, memory, or concentration after COVID, this might help.
Birmingham, AlabamaAges 18 years+ - NCT06728774Recruiting
Cognitive rehab for veterans with depression and memory problems
This trial tests a cognitive rehabilitation program for veterans who have depression (MDD) and are experiencing trouble with memory, attention, or thinking. The goal is to see if the program can improve these cognitive issues.
Portland, OregonAges 18 years+ - NCT05273125Recruiting
Testing mobility and thinking in people with mild cognitive problems
This study looks at how well people with mild cognitive problems can think and move, using brief learning/thinking tests and a walking task. It may help researchers understand changes early enough to guide future care.
LilleAges 65 years+ - NCT06951919Recruiting
HOBSCOTCH study for memory help in MS
This trial tests a program called HOBSCOTCH to help people with MS who have memory or thinking problems. It also includes a caregiver who supports them.
Lebanon, New HampshireAges 20–75 - NCT06442943Recruiting
Digital brain training for people at risk of dementia
This trial tests a digital program designed to improve memory and thinking skills in people who are at high risk for dementia but do not yet have dementia.
Fuzhou, FujianAges 55 years+ - NCT06936397Recruiting
Cognitive therapy for schizophrenia: Brain changes and emotions
This trial tests a cognitive training program for people with schizophrenia to see if it improves thinking and emotional control, and how it affects brain activity measured by EEG.
IstanbulAges 18–55 - NCT06672367Recruiting
Balance and gaze exercises for brain health in older adults
This study looks at whether adding gaze stability exercises (eye and head movements) to balance training can improve thinking, balance, and walking steadiness in older adults with mild memory problems. It may help those who can follow simple instructions and join in physical activity.
IslamabadAges 55 years+ - NCT07073781Recruiting
Probiotics for Brain & Blood Sugar in Overweight Young Adults
This study tests whether taking a probiotic (a 'good bacteria' supplement) can help brain function (thinking, memory) and improve blood sugar control in overweight adults who have higher-than-normal blood sugar. If you're between 18-40, overweight, and don't have diabetes, you may be able to join.
Leeds, Greater ManchesterAges 18–40 - NCT06579677Recruiting
Watching small blood vessels in the brain over time
This study watches how small blood vessels in the brain change over time. It may help doctors understand brain health as people age.
Beijing, Beijing MunicipalityAges 50–75 - NCT06679296Recruiting
Aging and Memory Loss Study in China
This study looks at how aging affects memory and thinking. It uses brain scans, a spinal tap, and other tests to understand cognitive decline better.
Wenzhou, ZhejiangAges Any age - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT07114809Recruiting
Can brain stimulation and virtual reality boost thinking in MS?
This study tests whether a combination of gentle brain stimulation (tDCS) and virtual reality exercises can improve memory and thinking problems in people with multiple sclerosis. If you have mild to moderate disability and no major health issues, you may be able to join.
Genova, ItalyAges 18–65 - NCT05667857Recruiting
Tracking brain, mood, and quality of life after immunotherapy
This study follows people who have had advanced cancer and are now stable after immunotherapy, to see how thinking, mood, and daily life change over time. Some participants may also do an integrative brain-training program if they have memory or thinking problems.
Brussels, Brussels CapitalAges 18 years+ - NCT06930846Recruiting
Brain cancer cognitive training study
This study tests a home-based program called HOBSCOTCH-CA to help with memory and thinking problems after brain cancer treatment. The program uses phone and internet sessions to teach self-management skills.
Lebanon, New HampshireAges 18 years+ - NCT07589595RecruitingPhase 2
Donanemab for Early Cognitive Decline with Lewy Bodies
This study tests donanemab, an investigational drug designed to target amyloid proteins in the brain that may contribute to cognitive decline in people with early dementia with Lewy bodies. The trial aims to see if this treatment can slow cognitive decline and help preserve thinking and memory.
Chandler, ArizonaAges 55–85 - NCT07113483RecruitingPhase 3
Remimazolam vs. Midazolam for sedation in older adults having orthopedic surgery
This trial compares two sedatives, remimazolam and midazolam, to see which one leads to better recovery of thinking skills after orthopedic surgery. It is for people aged 65 and older who are having surgery on a bone or joint while awake but relaxed.
BucharestAges 65 years+ - NCT07392723RecruitingPhase 2
Flaxseed nutrition to protect memory in APOE4 adults
This study tests a special flaxseed-based nutrition drink to see if it can slow memory loss in older adults who have the APOE4 gene and mild cognitive impairment (early memory trouble). If you qualify, you'll take the drink daily for a year and have memory tests and brain scans.
New Brunswick, New JerseyAges 60 years+ - NCT07418008Recruiting
Thinking and memory study for people with liver cirrhosis
This study is creating a new test to measure thinking and memory problems in people with liver cirrhosis. It may help doctors find these problems earlier.
Ambāla, HaryanaAges 18–75 - NCT07452367Recruiting
Bentall surgery study: optic nerve and thinking ability
This study checks if swelling of the optic nerve sheath during heart surgery with a bypass machine is linked to changes in thinking ability after the operation. It may help understand why some people have mental fogginess after surgery.
Bursa, YıldırımAges 18–80
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Common questions
- Are there clinical trials for cognitive dysfunction?
- Yes. Clin2 currently lists 152 recruiting cognitive dysfunction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive dysfunction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive dysfunction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.